Cancer Stem Cells in Head and Neck Carcinomas: Identification and Possible Therapeutic Implications

2017 ◽  
pp. 89-102
Author(s):  
Elize Wolmarans ◽  
Sonja C. Boy ◽  
Sulette Nel ◽  
Anne E. Mercier ◽  
Michael Sean Pepper
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Therapeutic Implications ◽  
Head And Neck Carcinomas

scholarly journals Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Marcus M. Monroe ◽  
Eric C. Anderson ◽  
Daniel R. Clayburgh ◽  
Melissa H. Wong
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Neck Squamous Cell Carcinoma ◽  
Therapeutic Implications

Accumulating evidence suggests that self-renewal and differentiation capabilities reside only in a subpopulation of tumor cells, termed cancer stem cells (CSCs), whereas the remaining tumor cell population lacks the ability to initiate tumor development or support continued tumor growth. In head and neck squamous cell carcinoma (HNSCC), as with other malignancies, cancer stem cells have been increasingly shown to have an integral role in tumor initiation, disease progression, metastasis and treatment resistance. In this paper we summarize the current knowledge of the role of CSCs in HNSCC and discuss the therapeutic implications and future directions of this field.

scholarly journals Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications

Cancers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 616 ◽  
Author(s):  
Claudia Peitzsch ◽  
Jacqueline Nathansen ◽  
Sebastian I. Schniewind ◽  
Franziska Schwarz ◽  
Anna Dubrovska
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Locally Advanced ◽  
Neck Squamous Cell Carcinoma ◽  
Therapeutic Implications ◽  
Patients At Risk

Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. Despite advances in the treatment management, locally advanced disease has a poor prognosis, with a 5-year survival rate of approximately 50%. The growth of HNSCC is maintained by a population of cancer stem cells (CSCs) which possess unlimited self-renewal potential and induce tumor regrowth if not completely eliminated by therapy. The population of CSCs is not only a promising target for tumor treatment, but also an important biomarker to identify the patients at risk for therapeutic failure and disease progression. This review aims to provide an overview of the recent pre-clinical and clinical studies on the biology and potential therapeutic implications of HNSCC stem cells.

Different Aspects of Head and Neck Squamous Cell Carcinoma: Cancer Stem Cells, Their Niche and Targeted Therapy

2020 ◽  
Vol 15 ◽  
Author(s):  
Meriç Bilgiç Küçükgüven ◽  
Betül Çelebi-Saltik
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Targeted Therapy ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Crucial Role ◽  
Tumor Therapy ◽  
Neck Squamous Cell Carcinoma

: Head and Neck Squamous Cell Carcinoma (HNSCC) is categorized as the sixth most common cancer worldwide, with an incidence of more than 830,000 cases per year and a mortality rate of 50%. Tobacco use, alcohol consumption, and Human Papillomavirus infection are the prominent risks for HNSCC. Despite significant developments in the treatment of HNSCC, a high rate of recurrences makes the clinical situation worse and results in poor survival rates. Recent perspectives demonstrate that whereas epithelial transformation plays a crucial role in cancer development, tumor surrounding microenvironment takes part in progression of cancer as well. Cancer Stem Cells (CSCs), which harbor unlimited self-renewal capacity, have a crucial role in the growth of HNSCC and this cell population is responsible for tumor recurrence unless eliminated by targeted therapy. CSCs are not only a promising target for tumor therapy, but also a crucial biomarker to determine the patients at high risk for undetermined results and disease development. Just as the bone marrow which is the niche of hematopoietic and mesenchymal stem cells, is important for stem cells maintenance. Similarly, the concept of microenvironment is also important for the maintenance of CSCs. Apart from the cell-cell interactions, there are many parameters in the cancer microenvironment that affect the development of cancer, such as extracellular regulation, vascularization, microbial flora, pH and oxygenation. The purpose of this review is to introduce HNSCC, explain the role of CSCs and their microenvironment and refer to the conventional and novel targeted therapy for HNSCC and CSCs.

scholarly journals MicroRNA expression profiles of cancer stem cells in head and neck squamous cell carcinoma

2015 ◽  
Vol 47 (4) ◽  
pp. 1249-1256 ◽  
Author(s):  
KAZUYA YATA ◽  
LEVENT BEKIR BEDER ◽  
SHUNJI TAMAGAWA ◽  
MUNEKI HOTOMI ◽  
YOSHIHIKO HIROHASHI ◽  
...  
Keyword(s):  
Stem Cells ◽  
Squamous Cell Carcinoma ◽  
Cancer Stem Cells ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Expression Profiles ◽  
Microrna Expression ◽  
Neck Squamous Cell Carcinoma

scholarly journals Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications

2017 ◽  
Vol 14 (2) ◽  
pp. 372-384 ◽  
Author(s):  
Tamara J. Abou-Antoun ◽  
James S. Hale ◽  
Justin D. Lathia ◽  
Stephen M. Dombrowski
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Brain Cancer ◽  
Cell Biology ◽  
Therapeutic Implications ◽  
Adults And Children

Prognostic significance of lymphatic spread in head and neck carcinomas: Therapeutic implications

1985 ◽  
Vol 8 (2) ◽  
pp. 67-73 ◽  
Author(s):  
C. Grandi ◽  
M. Alloisio ◽  
D. Moglia ◽  
S. Podrecca ◽  
L. Sala ◽  
...  
Keyword(s):  
Head And Neck ◽  
Prognostic Significance ◽  
Lymphatic Spread ◽  
Therapeutic Implications ◽  
Head And Neck Carcinomas

Therapeutic implications of cancer stem cells

2004 ◽  
Vol 14 (1) ◽  
pp. 43-47 ◽  
Author(s):  
Muhammad Al-Hajj ◽  
Michael W Becker ◽  
Max Wicha ◽  
Irving Weissman ◽  
Michael F Clarke
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Therapeutic Implications

scholarly journals Hepatic Cancer Stem Cells: Molecular Mechanisms, Therapeutic Implications, and Circulating Biomarkers

Cancers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 4550
Author(s):  
Laura Gramantieri ◽  
Catia Giovannini ◽  
Fabrizia Suzzi ◽  
Ilaria Leoni ◽  
Francesca Fornari
Keyword(s):  
Stem Cells ◽  
Cancer Stem Cells ◽  
Anticancer Agents ◽  
Tumor Heterogeneity ◽  
Molecular Mechanisms ◽  
Driving Forces ◽  
Predictive Biomarkers ◽  
Molecular Classification ◽  
Circulating Biomarkers ◽  
Therapeutic Implications

Hepatocellular carcinoma (HCC) is one of the deadliest cancers. HCC is associated with multiple risk factors and is characterized by a marked tumor heterogeneity that makes its molecular classification difficult to apply in the clinics. The lack of circulating biomarkers for the diagnosis, prognosis, and prediction of response to treatments further undermines the possibility of developing personalized therapies. Accumulating evidence affirms the involvement of cancer stem cells (CSCs) in tumor heterogeneity, recurrence, and drug resistance. Owing to the contribution of CSCs to treatment failure, there is an urgent need to develop novel therapeutic strategies targeting, not only the tumor bulk, but also the CSC subpopulation. Clarification of the molecular mechanisms influencing CSC properties, and the identification of their functional roles in tumor progression, may facilitate the discovery of novel CSC-based therapeutic targets to be used alone, or in combination with current anticancer agents, for the treatment of HCC. Here, we review the driving forces behind the regulation of liver CSCs and their therapeutic implications. Additionally, we provide data on their possible exploitation as prognostic and predictive biomarkers in patients with HCC.

scholarly journals FGFR signaling regulates resistance of head and neck cancer stem cells to cisplatin

Oncotarget ◽  
2018 ◽  
Vol 9 (38) ◽  
pp. 25148-25165 ◽  
Author(s):  
Sarah C. McDermott ◽  
Christie Rodriguez-Ramirez ◽  
Sean P. McDermott ◽  
Max S. Wicha ◽  
Jacques E. Nör
Keyword(s):  
Stem Cells ◽  
Head And Neck Cancer ◽  
Cancer Stem Cells ◽  
Head And Neck ◽  
Neck Cancer ◽  
Fgfr Signaling
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