Prognostic Value of Osteoprotegerin and sRANKL in Bronchoalveolar Lavage Fluid of Patients with Advanced Non-small Cell Lung Cancer

2017 ◽  
pp. 1-6 ◽  
Author(s):  
W. Naumnik ◽  
I. Płońska ◽  
M. Ossolińska ◽  
J. Nikliński ◽  
B. Naumnik
Keyword(s):  
Lung Cancer ◽  
Bronchoalveolar Lavage ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Prognostic Value ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Small Cell ◽  
Small Cell Lung

scholarly journals Pentraxin 3 (PTX-3) Levels in Bronchoalveolar Lavage Fluid as a Lung Cancer Biomarker

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Tinghua Hu ◽  
LiBang Qiao ◽  
Hong Li ◽  
Hui Ren ◽  
Qian Ning ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Bronchoalveolar Lavage ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Small Cell ◽  
Pentraxin 3 ◽  
Small Cell Lung ◽  
Lung Cancer Biomarker

In this study, we investigated the utility of pentraxin 3 (PTX-3) in bronchoalveolar lavage fluid (BALF) as lung cancer (LCa) diagnostic. A total of 89 LCa patients and 84 non-LCa patients who received bronchoscopy in the First Affiliated Hospital of Xi’an Jiaotong University from December 2014 to February 2015 were enrolled. LCa was subdivided according to pathological type (scale, gland, and small cell lung cancer). BALF samples were obtained during bronchoscopy and PTX-3 levels assayed by ELISA. t-tests, Mann-Whitney, and Kruskal-Wallis tests were performed for the comparison of PTX-3 levels between the different groups. Correlation analysis and receiver operating characteristic (ROC) analysis were used to analyze clinical data. The levels of PTX-3 increased in the LCa groups. PTX-3 levels were higher in the small cell lung cancer (SCLC) compared to non-small-cell lung cancer (NSCLC) groups. In LCa patients, obstructive pneumonia could upregulate the expression of PTX-3 in BALF. The area under the ROC curve of PTX-3 in BALF during LCa diagnosis, SCLC, and LCa with obstructive pneumonia was 0.949 (p≤0.001), 0.672 (p<0.05), and 0.838 (p<0.01), respectively. In conclusion, PTX-3 in BALF has a potential value as an LCa biomarker, particularly in cases of SCLC and LCa with obstructive pneumonia.

scholarly journals Interleukin 27 in bronchoalveolar lavage fluid in patients with non– small cell lung cancer

2018 ◽  
Vol 128 (4) ◽  
pp. 266-266
Author(s):  
Tomohiro Tamura ◽  
Toshihiro Shiozawa ◽  
Hideyasu Yamada ◽  
Kunihiko Miyazaki ◽  
Hiroaki Satoh
Keyword(s):  
Lung Cancer ◽  
Bronchoalveolar Lavage ◽  
Small Cell Lung Cancer ◽  
Cell Lung Cancer ◽  
Bronchoalveolar Lavage Fluid ◽  
Lavage Fluid ◽  
Small Cell ◽  
Small Cell Lung ◽  
Interleukin 27
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