Prevalence of Olfactory Impairment in Granulomatosis with Polyangiitis

2015 ◽  
pp. 1-7
Author(s):  
K. Zycinska ◽  
M. Straburzynski ◽  
A. Nitsch-Osuch ◽  
R. Krupa ◽  
M. Hadzik-Błaszczyk ◽  
...  
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Olfactory Impairment

Clinical features of orbital granulomatosis with polyangiitis (Wegener)

2020 ◽  
pp. 302-303
Author(s):  
D.S. Ismailova ◽  
◽  
P.I. Novikov ◽  
Y.O. Grusha ◽  
◽  
...  
Keyword(s):  
Clinical Features ◽  
Granulomatosis With Polyangiitis

scholarly journals Aortic valve replacement due to granulomatosis with polyangiitis: a case series

2020 ◽  
Vol 4 (5) ◽  
pp. 1-6
Author(s):  
Gilles Uijtterhaegen ◽  
Laura De Donder ◽  
Eline Ameloot ◽  
Kristof Lefebvre ◽  
Jo Van Dorpe ◽  
...  
Keyword(s):  
Heart Disease ◽  
Infective Endocarditis ◽  
Aortic Valve ◽  
Valve Replacement ◽  
Valvular Heart Disease ◽  
Granulomatosis With Polyangiitis ◽  
Surrounding Tissue ◽  
Valve Regurgitation ◽  
Aortic Valve Regurgitation ◽  
Severe Aortic Regurgitation

Abstract Background Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, is a systemic inflammatory process predominantly affecting upper and lower respiratory tract and kidneys. Valvular heart disease is a rare manifestation of GPA. Case summary We report two cases of acute valvular heart disease mimicking acute endocarditis caused by GPA. Both patients were middle-aged females with acute aortic valve regurgitation suggestive of possible infective endocarditis. In their recent medical history, atypical otitis and sinusitis were noted. The first patient was admitted with heart failure and the second patient because of persisting fever. Echocardiogram revealed severe aortic regurgitation with an additional structure on two cusps, suggestive of infective endocarditis in both patients. Urgent surgical replacement was performed; however, intraoperative findings did not show infective endocarditis, but severe inflammatory changes of the valve and surrounding tissue. In both patients, the valve was replaced by a prosthetic valve. Microscopic examination of the valve/myocardial biopsy showed diffuse acute and chronic inflammation with necrosis and necrotizing granulomas, compatible with GPA after infectious causes were excluded. Disease remission was obtained in both patients, in one patient with Rituximab and in the other with Glucocorticoids and Cyclophosphamide. Both had an uneventful follow-up. Discussion Granulomatosis with polyangiitis can be a rare cause of acute aortic valve regurgitation mimicking infective endocarditis with the need for surgical valve replacement. Atypical ear, nose, and throat symptoms can be a first sign of GPA. Symptom recognition is important for early diagnosis and appropriate treatment to prevent further progression of the disease.

scholarly journals Pituitary granulomatosis with polyangiitis

2013 ◽  
Vol 2013 (may03 1) ◽  
pp. bcr2013008656-bcr2013008656 ◽  
Author(s):  
H. Slabu ◽  
T. Arnason
Keyword(s):  
Granulomatosis With Polyangiitis
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