The role of metabolomics in systems biology

2007 ◽  
pp. 1-10 ◽  
Author(s):  
Jens Nielsen ◽  
Michael C. Jewett
Keyword(s):  
Systems Biology

Using integrative lipid systems biology to understand the role of Liver X receptors (LXRs) in male reproduction

2018 ◽  
Author(s):  
Sheba Jarvis ◽  
Lee Gethings ◽  
Raffaella Gadeleta ◽  
Emmanuelle Claude ◽  
Robert Winston ◽  
...  
Keyword(s):  
Systems Biology ◽  
Male Reproduction ◽  
Liver X Receptors ◽  
X Receptors

A systems biology approach to studying the role of microbes in human health

2013 ◽  
Vol 24 (1) ◽  
pp. 4-12 ◽  
Author(s):  
Ines Thiele ◽  
Almut Heinken ◽  
Ronan MT Fleming
Keyword(s):  
Systems Biology ◽  
Human Health

scholarly journals Role of cytoskeletal proteins in cerebral cavernous malformation signaling pathways: a proteomic analysis

2014 ◽  
Vol 10 (7) ◽  
pp. 1881-1889 ◽  
Author(s):  
Sarah Schwartz Baxter ◽  
Christopher F. Dibble ◽  
Warren C. Byrd ◽  
Jim Carlson ◽  
Charles Russell Mack ◽  
...  
Keyword(s):  
Systems Biology ◽  
Signaling Pathways ◽  
Proteomic Analysis ◽  
Cavernous Malformation ◽  
Cytoskeletal Proteins ◽  
Cerebral Cavernous Malformation

Anin vitroproteomics and systems biology of cerebral cavernous malformation.

scholarly journals The application of omics techniques to understand the role of the gut microbiota in inflammatory bowel disease

2019 ◽  
Vol 12 ◽  
pp. 175628481882225 ◽  
Author(s):  
Jonathan P. Segal ◽  
Benjamin H. Mullish ◽  
Mohammed Nabil Quraishi ◽  
Animesh Acharjee ◽  
Horace R. T. Williams ◽  
...  
Keyword(s):  
Systems Biology ◽  
Gut Microbiota ◽  
Potential Role ◽  
Intestinal Inflammation ◽  
Clinical Care ◽  
Complex Interaction ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Compositional Changes

The aetiopathogenesis of inflammatory bowel diseases (IBD) involves the complex interaction between a patient’s genetic predisposition, environment, gut microbiota and immune system. Currently, however, it is not known if the distinctive perturbations of the gut microbiota that appear to accompany both Crohn’s disease and ulcerative colitis are the cause of, or the result of, the intestinal inflammation that characterizes IBD. With the utilization of novel systems biology technologies, we can now begin to understand not only details about compositional changes in the gut microbiota in IBD, but increasingly also the alterations in microbiota function that accompany these. Technologies such as metagenomics, metataxomics, metatranscriptomics, metaproteomics and metabonomics are therefore allowing us a deeper understanding of the role of the microbiota in IBD. Furthermore, the integration of these systems biology technologies through advancing computational and statistical techniques are beginning to understand the microbiome interactions that both contribute to health and diseased states in IBD. This review aims to explore how such systems biology technologies are advancing our understanding of the gut microbiota, and their potential role in delineating the aetiology, development and clinical care of IBD.

scholarly journals Systems biology approach to elucidation of contaminant biodegradation in complex samples – integration of high-resolution analytical and molecular tools

2019 ◽  
Vol 218 ◽  
pp. 481-504 ◽  
Author(s):  
Caroline Gauchotte-Lindsay ◽  
Thomas J. Aspray ◽  
Mara Knapp ◽  
Umer Z. Ijaz
Keyword(s):  
Systems Biology ◽  
High Resolution ◽  
Microbial Communities ◽  
Contaminated Soils ◽  
Rational Design ◽  
Data Driven ◽  
Molecular Tools ◽  
Complex Samples ◽  
Driven Systems

We present here a data-driven systems biology framework for the rational design of biotechnological solutions for contaminated environments with the aim of understanding the interactions and mechanisms underpinning the role of microbial communities in the biodegradation of contaminated soils.

scholarly journals Potential role of atomic force microscopy in systems biology

2011 ◽  
Vol 3 (6) ◽  
pp. 702-716 ◽  
Author(s):  
Srinivasan Ramachandran ◽  
Fernando Teran Arce ◽  
Ratnesh Lal
Keyword(s):  
Atomic Force Microscopy ◽  
Systems Biology ◽  
Potential Role ◽  
Force Microscopy ◽  
Atomic Force
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