Ghrelin: From Gene to Physiological Function

2009 ◽  
pp. 85-96 ◽  
Author(s):  
Masayasu Kojima ◽  
Kenji Kangawa
Keyword(s):  
Physiological Function

Ultrastructure of Choriocarcinoma in Vitro

1969 ◽  
Vol 27 ◽  
pp. 362-363
Author(s):  
John C. Garancis ◽  
R. A. Pattillo
Keyword(s):  
Cell Line ◽  
Physiological Function ◽  
Cell System ◽  
Bewo Cell ◽  
Bewo Cells ◽  
Gestational Choriocarcinoma ◽  
Bewo Cell Line

Growth of cell system (BeWo-cell line) derived from human gestational choriocarcinoma has been established and continuously maintained in-vitro. Furthermore, it is evident from the previous studies that this cell line has retained the physiological function of the placental trophoblasts, namely the synthesis of human chorionic gonadotrophil(HCG).The BeWo cells were relatively small and possessed single nuclei, thus indicating that this cell line consists exclusively of cytotrophoblasts. In some instances cells appeared widely separated and their lateral surfaces were provided with numerous microvilli (Fig.1).

The Physiological Function of Heparin

1975 ◽  
Vol 33 (01) ◽  
pp. 017-019
Author(s):  
F Koller
Keyword(s):  
Physiological Function

The Na+/H+ antiport of eukaryotic cells: Relationship between the kinetic properties of the system and its physiological function

Biochimie ◽  
1986 ◽  
Vol 68 (12) ◽  
pp. 1279-1285 ◽  
Author(s):  
Christian Frelin ◽  
Pascal Barbry ◽  
Richard D. Green ◽  
Thierry Jean ◽  
Paul Vigne ◽  
...  
Keyword(s):  
Physiological Function ◽  
Eukaryotic Cells ◽  
Kinetic Properties

scholarly journals Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives

2021 ◽  
Vol 10 (7) ◽  
pp. 1392
Author(s):  
Ditte S. Kornum ◽  
Astrid J. Terkelsen ◽  
Davide Bertoli ◽  
Mette W. Klinge ◽  
Katrine L. Høyer ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Autonomic Dysfunction ◽  
Physiological Function ◽  
Clinical Performance ◽  
Data Interpretation ◽  
Assessment Methods ◽  
Common Finding ◽  
Colonic Manometry ◽  
Target Organs ◽  
Common Causes

The autonomic nervous system delicately regulates the function of several target organs, including the gastrointestinal tract. Thus, nerve lesions or other nerve pathologies may cause autonomic dysfunction (AD). Some of the most common causes of AD are diabetes mellitus and α-synucleinopathies such as Parkinson’s disease. Widespread dysmotility throughout the gastrointestinal tract is a common finding in AD, but no commercially available method exists for direct verification of enteric dysfunction. Thus, assessing segmental enteric physiological function is recommended to aid diagnostics and guide treatment. Several established assessment methods exist, but disadvantages such as lack of standardization, exposure to radiation, advanced data interpretation, or high cost, limit their utility. Emerging methods, including high-resolution colonic manometry, 3D-transit, advanced imaging methods, analysis of gut biopsies, and microbiota, may all assist in the evaluation of gastroenteropathy related to AD. This review provides an overview of established and emerging assessment methods of physiological function within the gut and assessment methods of autonomic neuropathy outside the gut, especially in regards to clinical performance, strengths, and limitations for each method.

scholarly journals Functional Characterization of the mazEF Toxin-Antitoxin System in the Pathogenic Bacterium Agrobacterium tumefaciens

2021 ◽  
Vol 9 (5) ◽  
pp. 1107
Author(s):  
Wonho Choi ◽  
Yoshihiro Yamaguchi ◽  
Ji-Young Park ◽  
Sang-Hyun Park ◽  
Hyeok-Won Lee ◽  
...  
Keyword(s):  
Agrobacterium Tumefaciens ◽  
Physiological Function ◽  
Functional Characterization ◽  
Site Directed Mutagenesis ◽  
In Vitro Assays ◽  
Cell Growth Inhibition ◽  
The Right

Agrobacterium tumefaciens is a pathogen of various plants which transfers its own DNA (T-DNA) to the host plants. It is used for producing genetically modified plants with this ability. To control T-DNA transfer to the right place, toxin-antitoxin (TA) systems of A. tumefaciens were used to control the target site of transfer without any unintentional targeting. Here, we describe a toxin-antitoxin system, Atu0939 (mazE-at) and Atu0940 (mazF-at), in the chromosome of Agrobacterium tumefaciens. The toxin in the TA system has 33.3% identity and 45.5% similarity with MazF in Escherichia coli. The expression of MazF-at caused cell growth inhibition, while cells with MazF-at co-expressed with MazE-at grew normally. In vivo and in vitro assays revealed that MazF-at inhibited protein synthesis by decreasing the cellular mRNA stability. Moreover, the catalytic residue of MazF-at was determined to be the 24th glutamic acid using site-directed mutagenesis. From the results, we concluded that MazF-at is a type II toxin-antitoxin system and a ribosome-independent endoribonuclease. Here, we characterized a TA system in A. tumefaciens whose understanding might help to find its physiological function and to develop further applications.

scholarly journals Landscape condition influences energetics, reproduction, and stress biomarkers in grizzly bears

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Abbey E. Wilson ◽  
Dan Wismer ◽  
Gordon Stenhouse ◽  
Nicholas C. Coops ◽  
David M. Janz
Keyword(s):  
Protein Expression ◽  
Physiological Function ◽  
A Priori ◽  
Food Resources ◽  
Information Criteria ◽  
Complement C3 ◽  
Grizzly Bears ◽  
Theoretic Approach ◽  
Protein Food ◽  
The Impact

AbstractEnvironmental change has been shown to influence mammalian distribution, habitat use, and behavior; however, few studies have investigated the impact on physiological function. This study aimed to determine the influence of landscape condition on the expression of target proteins related to energetics, reproduction, and stress in grizzly bears. We hypothesized that changes in landscape condition explains protein expression. Skin biopsies were collected from free-ranging grizzly bears in Alberta, Canada from 2013–2019 (n = 86 individuals). We used an information theoretic approach to develop 11 a priori candidate generalized linear mixed models to explain protein expression. We compared models using Akaike Information Criteria (AICc) weights and averaged models with ΔAICc < 2 for each protein. Food resources, represented by increased distance to coal mines and decreased crown closure, positively influenced energetic proteins (adiponectin and alpha-1-acid glycoprotein). Proteins related to reproduction (ceruloplasmin and serpin B5) were positively associated with increased wetland and upland food resources in addition to movement, but negatively associated with increased distance to roads. One stress related protein, complement C3, was positively influenced by increased percent conifer. Given the need to detect emerging threats to wildlife, we suggest the assessment of physiological function will lead to improved monitoring of species in rapidly changing landscapes.

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