Critical Roles for Microtubules in Axonal Development and Disease

2009 ◽  
pp. 47-64 ◽  
Author(s):  
Aditi Falnikar ◽  
Peter W. Baas
Keyword(s):  
Axonal Development

Axonal Development

1991 ◽  
pp. 163-222
Author(s):  
Marcus Jacobson
Keyword(s):  
Axonal Development

scholarly journals Axonal Development: RhoA Restrains but Does Not Specify

2019 ◽  
Vol 29 (22) ◽  
pp. R1179-R1181
Author(s):  
Anton Omelchenko ◽  
Bonnie L. Firestein
Keyword(s):  
Axonal Development

scholarly journals Drosophila Tet Is Expressed in Midline Glia and Is Required for Proper Axonal Development

2019 ◽  
Vol 13 ◽  
Author(s):  
Joy N. Ismail ◽  
Shireen Badini ◽  
Felice Frey ◽  
Wassim Abou-Kheir ◽  
Margret Shirinian
Keyword(s):  
Axonal Development

scholarly journals In vivo epigenetic editing of Sema6a promoter reverses transcallosal dysconnectivity caused by C11orf46/Arl14ep risk gene

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Cyril J. Peter ◽  
Atsushi Saito ◽  
Yuto Hasegawa ◽  
Yuya Tanaka ◽  
Mohika Nagpal ◽  
...  
Keyword(s):  
Therapeutic Potential ◽  
Gene Promoters ◽  
Risk Genes ◽  
Risk Gene ◽  
Axonal Development ◽  
Repressor Proteins ◽  
Repressor Complex ◽  
Genes Encoding ◽  
Epigenetic Editing

Abstract Many neuropsychiatric risk genes contribute to epigenetic regulation but little is known about specific chromatin-associated mechanisms governing the formation of neuronal connectivity. Here we show that transcallosal connectivity is critically dependent on C11orf46, a nuclear protein encoded in the chromosome 11p13 WAGR risk locus. C11orf46 haploinsufficiency was associated with hypoplasia of the corpus callosum. C11orf46 knockdown disrupted transcallosal projections and was rescued by wild type C11orf46 but not the C11orf46R236H mutant associated with intellectual disability. Multiple genes encoding key regulators of axonal development, including Sema6a, were hyperexpressed in C11orf46-knockdown neurons. RNA-guided epigenetic editing of Sema6a gene promoters via a dCas9-SunTag system with C11orf46 binding normalized SEMA6A expression and rescued transcallosal dysconnectivity via repressive chromatin remodeling by the SETDB1 repressor complex. Our study demonstrates that interhemispheric communication is sensitive to locus-specific remodeling of neuronal chromatin, revealing the therapeutic potential for shaping the brain’s connectome via gene-targeted designer activators and repressor proteins.

Axonal development in the cerebral white matter of the human fetus and infant

2005 ◽  
Vol 484 (2) ◽  
pp. 156-167 ◽  
Author(s):  
Robin L. Haynes ◽  
Natalia S. Borenstein ◽  
Tara M. Desilva ◽  
Rebecca D. Folkerth ◽  
Lena G. Liu ◽  
...  
Keyword(s):  
White Matter ◽  
Human Fetus ◽  
Cerebral White Matter ◽  
Axonal Development

scholarly journals Drosophila Futsch/22C10 Is a MAP1B-like Protein Required for Dendritic and Axonal Development

Neuron ◽  
2000 ◽  
Vol 26 (2) ◽  
pp. 357-370 ◽  
Author(s):  
Thomas Hummel ◽  
Karin Krukkert ◽  
Jack Roos ◽  
Graeme Davis ◽  
Christian Klämbt
Keyword(s):  
Axonal Development
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