scholarly journals The Biophysics of T Lymphocyte Activation In Vitro and In Vivo

2006 ◽  
pp. 199-218 ◽  
Author(s):  
Peter Reichardt ◽  
Matthias Gunzer
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Activation ◽  
T Lymphocyte Activation

Investigation of effects of farrerol on suppression of murine T lymphocyte activation in vitro and in vivo

2013 ◽  
Vol 16 (2) ◽  
pp. 313-321 ◽  
Author(s):  
Ying Xiong ◽  
Shuang Zhang ◽  
Jing Lu ◽  
Shicheng Sun ◽  
Bocui Song ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Activation ◽  
T Lymphocyte Activation

In vitro and in vivo immunostimulatory potential of bone marrow–derived mast cells on B- and T-lymphocyte activation

2000 ◽  
Vol 105 (1) ◽  
pp. 134-142 ◽  
Author(s):  
Christine Tkaczyk ◽  
Irène Villa ◽  
Roger Peroneta ◽  
Bernard David ◽  
Salem Chouaib ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mast Cells ◽  
T Lymphocyte ◽  
Lymphocyte Activation ◽  
T Lymphocyte Activation

scholarly journals Structural and functional studies of the early T lymphocyte activation 1 (Eta-1) gene. Definition of a novel T cell-dependent response associated with genetic resistance to bacterial infection.

1989 ◽  
Vol 170 (1) ◽  
pp. 145-161 ◽  
Author(s):  
R Patarca ◽  
G J Freeman ◽  
R P Singh ◽  
F Y Wei ◽  
T Durfee ◽  
...  
Keyword(s):  
T Cell ◽  
Bacterial Infection ◽  
T Lymphocyte ◽  
Inbred Mouse ◽  
Genetic Resistance ◽  
Lymphocyte Activation ◽  
Cellular Adhesion ◽  
Mouse Strains ◽  
T Lymphocyte Activation

We describe a murine cDNA, designated Early T lymphocyte activation 1 (ETA-1) which is abundantly expressed after activation of T cells. Eta-1 encodes a highly acidic secreted product having structural features of proteins that bind to cellular adhesion receptors. The Eta-1 gene maps to a locus on murine chromosome 5 termed Ric that confers resistance to infection by Rickettsia tsutsugamushi (RT), an obligate intracellular bacterium that is the etiological agent for human scrub typhus. With one exception, inbred mouse strains that expressed the Eta-1a allele were resistant to RT infection (RicR), and inbred strains expressing the Eta-1b allele were susceptible (RicS). These findings suggest that Eta-1 is the gene inferred from previous studies of the Ric locus (5). Genetic resistance to RT infection is associated with a strong Eta-1 response in vivo and inhibition of early bacterial replication. Eta-1 gene expression appears to be part of a surprisingly rapid T cell-dependent response to bacterial infection that may precede classical forms of T cell-dependent immunity.

Over-expression of MiRRA2 in vivo Impairs T Lymphocyte Activation

2010 ◽  
Vol 125 (2) ◽  
pp. AB76
Author(s):  
J. Wang ◽  
K. Li ◽  
W. Zhang ◽  
R.F. Lockey ◽  
S. Mohapatra ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Activation ◽  
Over Expression ◽  
T Lymphocyte Activation

scholarly journals Human plasma-like medium improves T lymphocyte activation

2019 ◽  
Author(s):  
Michael A. Leney-Greene ◽  
Arun K. Boddapati ◽  
Helen C. Su ◽  
Jason Cantor ◽  
Michael J. Lenardo
Keyword(s):  
Human Plasma ◽  
T Cell Activation ◽  
T Lymphocyte ◽  
Cell Activation ◽  
Lymphocyte Activation ◽  
Cell Physiology ◽  
Transcriptional Responses ◽  
T Lymphocyte Activation ◽  
Synthetic Media

SUMMARYT lymphocytes are critical for effective immunity and the ability to study their behavior in synthetic media in vitro facilitates major discoveries in their development, function, and fate. However, the composition of human plasma differs from synthetic media and we hypothesized that these differences could have important effects on cell physiology. We therefore compared T lymphocyte activation in human plasma-like medium (HPLM) to RPMI supplemented with dialyzed FBS (RPMIdFBS) and found that it entrained markedly different transcriptional responses. We also found that the concentration of calcium in RPMIdFBS is six-fold lower than HPLM causing altered T cell activation which could be reversed by calcium addition. Thus, investigators should be cognizant of differences between commonly used media formulations and HPLM which is based on the in vivo plasma environment as these could profoundly affect their experimental results. Physiologic media may be a valuable new way to study immune cells in culture.

Suppression of T lymphocyte activation by 3-chloro-1,2-propanediol mono- and di-palmitate esters in vitro

2018 ◽  
Vol 51 ◽  
pp. 54-62 ◽  
Author(s):  
Guoren Huang ◽  
Jinli Xue ◽  
Xiangjun Sun ◽  
Jing Wang ◽  
Yilin Wang ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Lymphocyte Activation ◽  
T Lymphocyte Activation
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