Cell–cell communication by Endocannabinoids during Immune Surveillance of the Central Nervous System

2006 ◽  
pp. 281-305 ◽  
Author(s):  
Oliver Ullrich ◽  
Regine Schneider-Stock ◽  
Frauke Zipp
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immune Surveillance ◽  
Cell Communication ◽  
The Central Nervous System ◽  
Cell Cell

Innate Immune Surveillance in the Central Nervous System Following Legionella pneumophila Infection

2018 ◽  
Vol 16 (10) ◽  
pp. 1080-1089 ◽  
Author(s):  
Pasqualina Lagana ◽  
Luca Soraci ◽  
Maria Elsa Gambuzza ◽  
Giuseppe Mancuso ◽  
Santi Antonino Delia
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Legionella Pneumophila ◽  
Immune Surveillance ◽  
Innate Immune ◽  
The Central Nervous System

scholarly journals Immune surveillance in the central nervous system

2012 ◽  
Vol 15 (8) ◽  
pp. 1096-1101 ◽  
Author(s):  
Shalina S Ousman ◽  
Paul Kubes
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immune Surveillance ◽  
The Central Nervous System

Role of genetic background in P selectin-dependent immune surveillance of the central nervous system

2002 ◽  
Vol 129 (1-2) ◽  
pp. 51-57 ◽  
Author(s):  
Michael D Carrithers ◽  
Irene Visintin ◽  
Christophe Viret ◽  
Charles A Janeway
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Genetic Background ◽  
Immune Surveillance ◽  
The Central Nervous System

scholarly journals Pivotal Role for CD16+ Monocytes in Immune Surveillance of the Central Nervous System

2016 ◽  
Vol 196 (4) ◽  
pp. 1558-1567 ◽  
Author(s):  
Anne Waschbisch ◽  
Sina Schröder ◽  
Dana Schraudner ◽  
Laura Sammet ◽  
Babette Weksler ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Immune Surveillance ◽  
Pivotal Role ◽  
The Central Nervous System

scholarly journals Extracellular Vesicle-Mediated Cell–Cell Communication in the Nervous System: Focus on Neurological Diseases

2019 ◽  
Vol 20 (2) ◽  
pp. 434 ◽  
Author(s):  
Celeste Caruso Bavisotto ◽  
Federica Scalia ◽  
Antonella Marino Gammazza ◽  
Daniela Carlisi ◽  
Fabio Bucchieri ◽  
...  
Keyword(s):  
Nervous System ◽  
Neurological Diseases ◽  
Cell Communication ◽  
Cell Types ◽  
Extracellular Vesicle ◽  
Response To Treatment ◽  
Therapeutic Drugs ◽  
The Central Nervous System ◽  
Bioengineering Techniques ◽  
Cell Cell

Extracellular vesicles (EVs), including exosomes, are membranous particles released by cells into the extracellular space. They are involved in cell differentiation, tissue homeostasis, and organ remodelling in virtually all tissues, including the central nervous system (CNS). They are secreted by a range of cell types and via blood reaching other cells whose functioning they can modify because they transport and deliver active molecules, such as proteins of various types and functions, lipids, DNA, and miRNAs. Since they are relatively easy to isolate, exosomes can be characterized, and their composition elucidated and manipulated by bioengineering techniques. Consequently, exosomes appear as promising theranostics elements, applicable to accurately diagnosing pathological conditions, and assessing prognosis and response to treatment in a variety of disorders. Likewise, the characteristics and manageability of exosomes make them potential candidates for delivering selected molecules, e.g., therapeutic drugs, to specific target tissues. All these possible applications are pertinent to research in neurophysiology, as well as to the study of neurological disorders, including CNS tumors, and autoimmune and neurodegenerative diseases. In this brief review, we discuss what is known about the role and potential future applications of exosomes in the nervous system and its diseases, focusing on cell–cell communication in physiology and pathology.

scholarly journals Role of Connexins 30, 36, and 43 in Brain Tumors, Neurodegenerative Diseases, and Neuroprotection

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 846 ◽  
Author(s):  
Oscar F. Sánchez ◽  
Andrea V. Rodríguez ◽  
José M. Velasco-España ◽  
Laura C. Murillo ◽  
Jhon-Jairo Sutachan ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neurodegenerative Diseases ◽  
Posttranslational Modifications ◽  
Cell Communication ◽  
Normal Function ◽  
Epigenetic Mechanisms ◽  
Communication Processes ◽  
The Central Nervous System

Gap junction (GJ) channels and their connexins (Cxs) are complex proteins that have essential functions in cell communication processes in the central nervous system (CNS). Neurons, astrocytes, oligodendrocytes, and microglial cells express an extraordinary repertory of Cxs that are important for cell to cell communication and diffusion of metabolites, ions, neurotransmitters, and gliotransmitters. GJs and Cxs not only contribute to the normal function of the CNS but also the pathological progress of several diseases, such as cancer and neurodegenerative diseases. Besides, they have important roles in mediating neuroprotection by internal or external molecules. However, regulation of Cx expression by epigenetic mechanisms has not been fully elucidated. In this review, we provide an overview of the known mechanisms that regulate the expression of the most abundant Cxs in the central nervous system, Cx30, Cx36, and Cx43, and their role in brain cancer, CNS disorders, and neuroprotection. Initially, we focus on describing the Cx gene structure and how this is regulated by epigenetic mechanisms. Then, the posttranslational modifications that mediate the activity and stability of Cxs are reviewed. Finally, the role of GJs and Cxs in glioblastoma, Alzheimer’s, Parkinson’s, and Huntington’s diseases, and neuroprotection are analyzed with the aim of shedding light in the possibility of using Cx regulators as potential therapeutic molecules.

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