1,2- Versus 1,4-Asymmetric Addition of Grignard Reagents to Carbonyl Compounds

2016 ◽  
pp. 99-134 ◽  
Author(s):  
Pablo Ortiz ◽  
Francesco Lanza ◽  
Syuzanna R. Harutyunyan
Keyword(s):  
Carbonyl Compounds ◽  
Grignard Reagents ◽  
Asymmetric Addition

Asymmetric Addition of Deactivated Grignard Reagents to Aldehydes

Synfacts ◽  
2010 ◽  
Vol 2010 (05) ◽  
pp. 0618-0618
Author(s):  
C.-S. Da ◽  
J.-R. Wang ◽  
X.-G. Yin ◽  
X.-Y. Fan ◽  
Y. Liu ◽  
...  
Keyword(s):  
Grignard Reagents ◽  
Asymmetric Addition

Asymmetric Addition Reactions of Grignard Reagents to Chiral 2-Trifluoromethyl tert-Butyl (Ellman) Sulfinimine—Ethanol Adducts.

ChemInform ◽  
2006 ◽  
Vol 37 (29) ◽  
Author(s):  
Scott D. Kuduk ◽  
Christina Ng Di Marco ◽  
Steven M. Pitzenberger ◽  
Nancy Tsou
Keyword(s):  
Grignard Reagents ◽  
Addition Reactions ◽  
Asymmetric Addition ◽  
Tert Butyl

Recent Advances in the Synthesis of Enantiomerically Enriched Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols through Addition of Organometallic Reagents to Carbonyl Compounds

Synthesis ◽  
2020 ◽  
Vol 52 (13) ◽  
pp. 1855-1873
Author(s):  
Senthil Narayanaperumal ◽  
Ricardo S. Schwab ◽  
Wystan K. O. Teixeira ◽  
Danilo Yano de Albuquerque
Keyword(s):  
Carbonyl Compounds ◽  
Building Blocks ◽  
Short Review ◽  
Biological Properties ◽  
Enantioselective Synthesis ◽  
Grignard Reagents ◽  
Organometallic Reagents ◽  
Important Family ◽  
Organolithium Reagents ◽  
Organozinc Reagents

Enantiomerically enriched diaryl, aryl heteroaryl, and dihetero­aryl alcohols are an important family of compounds known for their biological properties. Moreover, these molecules are highly privileged scaffolds used as building blocks for the synthesis of pharmaceutically relevant products. This short review provides background on the enantioselective arylation and heteroarylation of carbonyl compounds, as well as, the most significant improvements in this field with special emphasis on the application of organometallic reagents.1 Introduction2 Background on the Enantioselective Synthesis of Diaryl, Aryl Heteroaryl, and Diheteroaryl Alcohols3 Organozinc Reagents4 Organolithium Reagents5 Grignard Reagents6 Organoaluminum Reagents7 Organotitanium Reagents8 Organobismuth Reagents9 Miscellaneous10 Conclusion

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