Acid Catalysis in Organic Synthesis

2012 ◽  
pp. 315-334 ◽  
Author(s):  
Hisashi Yamamoto
Keyword(s):  
Organic Synthesis ◽  
Acid Catalysis

Asymmetric C-H and N-H functionalization of Indoles involving Central Chirality via Chiral Phosphoric Acid Catalysis

2021 ◽  
Vol 18 ◽  
Author(s):  
Alemayehu Gashaw ◽  
Dereje Kebebew Debeli ◽  
Meseret Chemeda
Keyword(s):  
Phosphoric Acid ◽  
Organic Compounds ◽  
Organic Synthesis ◽  
Acid Catalysis ◽  
Bond Formation ◽  
Acid Catalysts ◽  
Asymmetric Syntheses ◽  
Chiral Phosphoric Acid ◽  
Great Progress ◽  
Interesting Area

: The C-H and N-H functionalization of indoles is an interesting area of research that has a useful impact on organic synthesis due to the availability of chiral indole scaffolds in the discovery of drugs, synthetic bioactive compounds, and natural products. The chiral phosphoric acid catalysts (CPAs) have proven to be a powerful and versatile class of enantioselective organocatalysts. Many asymmetric syntheses of organic compounds have been carried out with these catalysts in C–C and C-N bond formation reactions, and great progress has been reported. By 2011, several reviews were published covering some important topics and recent achievements in this field. Therefore, in this review, the most recent advances, research breakthroughs with key examples involving mechanisms of CPA-catalyzed C-H and N-H functionalization of indoles to form central chirality via Friedel Crafts, Michael type, and rearrangement reactions were reviewed and reported.

ChemInform Abstract: Acid Catalysis in Organic Synthesis

ChemInform ◽  
2013 ◽  
Vol 44 (41) ◽  
pp. no-no
Author(s):  
Hisashi Yamamoto
Keyword(s):  
Organic Synthesis ◽  
Acid Catalysis

Polymer-Supported Acid Catalysis in Organic Synthesis

2011 ◽  
Vol 8 (2) ◽  
pp. 208-236 ◽  
Author(s):  
Ying Chang ◽  
Chulsung Bae
Keyword(s):  
Organic Synthesis ◽  
Acid Catalysis ◽  
Polymer Supported

Super Broensted Acid Catalysis in Organic Synthesis

ChemInform ◽  
2007 ◽  
Vol 38 (46) ◽  
Author(s):  
Hisashi Yamamoto ◽  
Matthew B. Boxer
Keyword(s):  
Organic Synthesis ◽  
Acid Catalysis

scholarly journals Boron-Based Lewis Acid Catalysis: Challenges and Perspectives

Catalysts ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 5
Author(s):  
Valeria Nori ◽  
Fabio Pesciaioli ◽  
Arianna Sinibaldi ◽  
Giuliana Giorgianni ◽  
Armando Carlone
Keyword(s):  
Organic Synthesis ◽  
Lewis Acid ◽  
Gold Standard ◽  
Lewis Acids ◽  
Acid Catalysis ◽  
Acid Catalysts ◽  
Chemical Transformations ◽  
Lewis Acid Catalysis ◽  
Lewis Acid Catalysts ◽  
Better Than

In the last two decades, boron-based catalysis has been gaining increasing traction in the field of organic synthesis. The use of halogenated triarylboranes as main group Lewis acid catalysts is an attractive strategy. It has been applied in a growing number of transformations over the years, where they may perform comparably or even better than the gold standard catalysts. This review discusses methods of borane synthesis and cutting-edge boron-based Lewis acid catalysis, focusing especially on tris(pentafluorophenyl)-borane [B(C6F5)3], and other halogenated triarylboranes, highlighting how boron Lewis acids employed as catalysts can unlock a plethora of unprecedented chemical transformations or improve the efficiency of existing reactions.

Sign in / Sign up

Export Citation Format

Share Document