Application of Ring-Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor

2012 ◽  
pp. 135-149 ◽  
Author(s):  
Cheng-yi Chen
Keyword(s):  
Protease Inhibitor ◽  
Ring Closing Metathesis ◽  
Hcv Protease

Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis

2006 ◽  
Vol 71 (19) ◽  
pp. 7133-7145 ◽  
Author(s):  
Nathan K. Yee ◽  
Vittorio Farina ◽  
Ioannis N. Houpis ◽  
Nizar Haddad ◽  
Rogelio P. Frutos ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Large Scale ◽  
Ring Closing Metathesis ◽  
Hcv Protease ◽  
Large Scale Synthesis ◽  
Convergent Approach

Synthesis of the HCV Protease Inhibitor Vaniprevir (MK-7009) Using Ring-Closing Metathesis Strategy

2012 ◽  
Vol 77 (8) ◽  
pp. 3820-3828 ◽  
Author(s):  
Jongrock Kong ◽  
Cheng-yi Chen ◽  
Jaume Balsells-Padros ◽  
Yang Cao ◽  
Robert F. Dunn ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Ring Closing Metathesis ◽  
Hcv Protease

Second-Generation Process for the HCV Protease Inhibitor BILN 2061: A Greener Approach to Ru-Catalyzed Ring-Closing Metathesis†

2009 ◽  
Vol 13 (2) ◽  
pp. 250-254 ◽  
Author(s):  
Vittorio Farina ◽  
Chutian Shu ◽  
Xingzhong Zeng ◽  
Xudong Wei ◽  
Zhengxu Han ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Second Generation ◽  
Generation Process ◽  
Ring Closing Metathesis ◽  
Hcv Protease

Synthesis of Bis-Macrocyclic HCV Protease Inhibitor MK-6325 via Intramolecular sp2–sp3 Suzuki–Miyaura Coupling and Ring Closing Metathesis

2015 ◽  
Vol 17 (6) ◽  
pp. 1533-1536 ◽  
Author(s):  
Hongmei Li ◽  
Jeremy P. Scott ◽  
Cheng-yi Chen ◽  
Michel Journet ◽  
Kevin Belyk ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Ring Closing Metathesis ◽  
Hcv Protease

Ring-Closing Metathesis on Commercial Scale: Synthesis of HCV Protease Inhibitor Simeprevir

2019 ◽  
Vol 84 (8) ◽  
pp. 4932-4939 ◽  
Author(s):  
András Horváth ◽  
Dominique Depré ◽  
Wim A. A. Vermeulen ◽  
Stijn L. Wuyts ◽  
Syuzanna R. Harutyunyan ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Ring Closing Metathesis ◽  
Commercial Scale ◽  
Hcv Protease

Discovery and Development of the HCV Protease Inhibitor TMC435

2011 ◽  
pp. 273-286
Author(s):  
Pierre Raboisson ◽  
Gregory Fanning ◽  
Herman de Kock ◽  
Åsa Rosenquist ◽  
René Verloes ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Hcv Protease

scholarly journals Clinical impact of pharmacokinetic interactions between the HCV protease inhibitor simeprevir and frequently used concomitant medications

2018 ◽  
Vol 84 (5) ◽  
pp. 961-971 ◽  
Author(s):  
Fiona Marra ◽  
Christoph Höner zu Siederdissen ◽  
Saye Khoo ◽  
David Back ◽  
Michael Schlag ◽  
...  
Keyword(s):  
Protease Inhibitor ◽  
Clinical Impact ◽  
Pharmacokinetic Interactions ◽  
Hcv Protease ◽  
Concomitant Medications
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