Progesterone Receptor Isoforms in Normal and Malignant Breast

2008 ◽  
pp. 190-207 ◽  
Author(s):  
P. A. Mote ◽  
J. D. Graham ◽  
C. L. Clarke
Keyword(s):  
Progesterone Receptor ◽  
Progesterone Receptor Isoforms ◽  
Receptor Isoforms ◽  
Malignant Breast

Progesterone receptor isoforms differentially regulate the expression of tryptophan and tyrosine hydroxylase and glutamic acid decarboxylase in the rat hypothalamus

2011 ◽  
Vol 59 (5) ◽  
pp. 671-676 ◽  
Author(s):  
Oscar González-Flores ◽  
Porfirio Gómora-Arrati ◽  
Marcos García-Juárez ◽  
Alfredo Miranda-Martínez ◽  
Alejandra Armengual-Villegas ◽  
...  
Keyword(s):  
Tyrosine Hydroxylase ◽  
Progesterone Receptor ◽  
Glutamic Acid ◽  
Glutamic Acid Decarboxylase ◽  
Acid Decarboxylase ◽  
Rat Hypothalamus ◽  
Progesterone Receptor Isoforms ◽  
Receptor Isoforms

Developmental expression of progesterone receptor isoforms in the mouse midbrain

Neuroreport ◽  
2002 ◽  
Vol 13 (6) ◽  
pp. 877-880 ◽  
Author(s):  
Cordian Beyer ◽  
Natalie Damm ◽  
Veronica Brito ◽  
Eva Küppers
Keyword(s):  
Progesterone Receptor ◽  
Developmental Expression ◽  
Progesterone Receptor Isoforms ◽  
Receptor Isoforms

Gene Expression of Progesterone Receptor Isoforms in the Rat Brain

1994 ◽  
Vol 28 (4) ◽  
pp. 454-463 ◽  
Author(s):  
Junzo Kato ◽  
Shuji Hirata ◽  
Akira Nozawa ◽  
Naoko Yamada-Mouri
Keyword(s):  
Gene Expression ◽  
Progesterone Receptor ◽  
Rat Brain ◽  
Progesterone Receptor Isoforms ◽  
Receptor Isoforms

Nuclear progesterone receptor isoforms and their functions in the female reproductive tract

2011 ◽  
Vol 14 (1) ◽  
pp. 149-158 ◽  
Author(s):  
R. Rękawiecki ◽  
M. Kowalik ◽  
J. Kotwica
Keyword(s):  
Progesterone Receptor ◽  
Receptor Antagonist ◽  
Reproductive System ◽  
Reproductive Tract ◽  
Physiological Effect ◽  
Female Reproductive Tract ◽  
Target Cells ◽  
Progesterone Receptor Isoforms ◽  
Receptor Isoforms ◽  
Nuclear Progesterone Receptor

Nuclear progesterone receptor isoforms and their functions in the female reproductive tract Progesterone (P4), which is produced by the corpus luteum (CL), creates proper conditions for the embryo implantation, its development, and ensures proper conditions for the duration of pregnancy. Besides the non-genomic activity of P4 on target cells, its main physiological effect is caused through genomic action by the progesterone nuclear receptor (PGR). This nuclear progesterone receptor occurs in two specific isoforms, PGRA and PGRB. PGRA isoform acts as an inhibitor of transcriptional action of PGRB. The inactive receptor is connected with chaperone proteins and attachment of P4 causes disconnection of chaperones and unveiling of DNA binding domain (DBD). After receptor dimerization in the cells' nucleus and interaction with hormone response element (HRE), the receptor coactivators are connected and transcription is initiated. The ratio of these isoforms changes during the estrous cycle and reflects the different levels of P4 effect on the reproductive system. Both isoforms, PGRA and PGRB, also show a different response to the P4 receptor antagonist activity. Connection of the antagonist to PGRA can block PGRB, but acting through the PGRB isoform, P4 receptor antagonist may undergo conversion to a strongly receptor agonist. A third isoform, PGRC, has also been revealed. This isoform is the shortest and does not have transcriptional activity. Alternative splicing and insertion of additional exons may lead to the formation of different PGR isoforms. This paper summarizes the available data on the progesterone receptor isoforms and its regulatory action within the female reproductive system.

Regulation of progesterone receptor isoforms expression by sex steroids in the rat lung

2003 ◽  
Vol 85 (1) ◽  
pp. 25-31 ◽  
Author(s):  
Aliesha González-Arenas ◽  
Olga Villamar-Cruz ◽  
Christian Guerra-Araiza ◽  
Ignacio Camacho-Arroyo
Keyword(s):  
Progesterone Receptor ◽  
Sex Steroids ◽  
Rat Lung ◽  
Progesterone Receptor Isoforms ◽  
Receptor Isoforms
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