Dynamic Regulation of Progesterone Receptor Activity in Female Reproductive Tissues

2007 ◽  
pp. 25-43 ◽  
Author(s):  
S. J. Han ◽  
F. J. DeMayo ◽  
B. W. O'Malley
Keyword(s):  
Progesterone Receptor ◽  
Receptor Activity ◽  
Dynamic Regulation ◽  
Reproductive Tissues

scholarly journals The Progesterone Receptor in Human Term Amniochorion and Placenta Is Isoform C

Endocrinology ◽  
2006 ◽  
Vol 147 (2) ◽  
pp. 687-693 ◽  
Author(s):  
Anthony H. Taylor ◽  
Penny C. McParland ◽  
David J. Taylor ◽  
Stephen C. Bell
Keyword(s):  
Progesterone Receptor ◽  
Western Blotting ◽  
Cell Types ◽  
Specific Role ◽  
Fetal Membranes ◽  
Rt Pcr ◽  
Reproductive Tissues ◽  
Pcr Techniques ◽  
Human Parturition ◽  
Extraembryonic Tissues

The mechanism that initiates human parturition has been proposed to be functional progesterone withdrawal whereby the 116-kDa B isoform of the progesterone receptor (PR-B) switches in favor of the 94-kDa A isoform (PR-A) in reproductive tissues. Recently other PR isoforms, PR-S, PR-C, and PR-M generated from the same gene have been identified and partially characterized. Using immunohistochemical, Western blotting, and RT-PCR techniques, evidence is provided that the major PR isoform present in human term fetal membranes (amnion and chorion) and syncytiotrophoblast of the placenta is neither of the classical nuclear PR-B or PR-A isoforms but is the N terminally truncated 60-kDa PR-C isoform. Evidence is also provided that the PR-C isoform resides in the cytoplasm of the expressing cell types. Data are also presented to show that PR-B, PR-A, and PR-S isoforms are essentially absent from the amnion and chorion, whereas PR isoforms A, B, C, and S are all present in the decidua, with PR-A being the major isoform. The syncytiotrophoblast of the placenta contains the cytoplasmic PR-C isoform but not PR-A, PR-B, or PR-S. The major PR isoform in the amnion, chorion, and placenta is PR-C, suggesting that the cytoplasmic PR-C isoform has a specific role in extraembryonic tissues and may be involved in the regulation of human parturition.

scholarly journals ERα-36 regulates progesterone receptor activity in breast cancer

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Henri-Philippe Konan ◽  
Loay Kassem ◽  
Soleilmane Omarjee ◽  
Ausra Surmieliova-Garnès ◽  
Julien Jacquemetton ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Progesterone Receptor ◽  
Receptor Activity

scholarly journals Cyclin dependent kinase 2 and the regulation of human progesterone receptor activity

Steroids ◽  
2007 ◽  
Vol 72 (2) ◽  
pp. 202-209 ◽  
Author(s):  
Nicole L. Moore ◽  
Ramesh Narayanan ◽  
Nancy L. Weigel
Keyword(s):  
Progesterone Receptor ◽  
Receptor Activity ◽  
Cyclin Dependent Kinase ◽  
Human Progesterone Receptor

scholarly journals Anthrax lethal factor represses glucocorticoid and progesterone receptor activity

2003 ◽  
Vol 100 (10) ◽  
pp. 5706-5711 ◽  
Author(s):  
J. I. Webster ◽  
L. H. Tonelli ◽  
M. Moayeri ◽  
S. S. Simons ◽  
S. H. Leppla ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Lethal Factor ◽  
Receptor Activity ◽  
Anthrax Lethal Factor
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