Dynamic MRI of Respiratory Mechanics and Pulmonary Motion

2017 ◽  
pp. 163-183 ◽  
Author(s):  
Jürgen Biederer ◽  
Monika Eichinger ◽  
Julien Dinkel
1998 ◽  
Vol 74 (4) ◽  
pp. 275-83
Author(s):  
Antônio C. P. Ferreira ◽  
Benjamin I. Kopelman ◽  
Werther Brunow de Carvalho ◽  
Jorge Bonassa

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 711.14-711
Author(s):  
R.P. Poggenborg ◽  
P. Bøyesen ◽  
C. Wiell ◽  
S.J. Pedersen ◽  
I.J. Sørensen ◽  
...  

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
J.-L. Diehl ◽  
N. Peron ◽  
R. Chocron ◽  
B. Debuc ◽  
E. Guerot ◽  
...  

Abstract Rationale COVID-19 ARDS could differ from typical forms of the syndrome. Objective Pulmonary microvascular injury and thrombosis are increasingly reported as constitutive features of COVID-19 respiratory failure. Our aim was to study pulmonary mechanics and gas exchanges in COVID-2019 ARDS patients studied early after initiating protective invasive mechanical ventilation, seeking after corresponding pathophysiological and biological characteristics. Methods Between March 22 and March 30, 2020 respiratory mechanics, gas exchanges, circulating endothelial cells (CEC) as markers of endothelial damage, and D-dimers were studied in 22 moderate-to-severe COVID-19 ARDS patients, 1 [1–4] day after intubation (median [IQR]). Measurements and main results Thirteen moderate and 9 severe COVID-19 ARDS patients were studied after initiation of high PEEP protective mechanical ventilation. We observed moderately decreased respiratory system compliance: 39.5 [33.1–44.7] mL/cmH2O and end-expiratory lung volume: 2100 [1721–2434] mL. Gas exchanges were characterized by hypercapnia 55 [44–62] mmHg, high physiological dead-space (VD/VT): 75 [69–85.5] % and ventilatory ratio (VR): 2.9 [2.2–3.4]. VD/VT and VR were significantly correlated: r2 = 0.24, p = 0.014. No pulmonary embolism was suspected at the time of measurements. CECs and D-dimers were elevated as compared to normal values: 24 [12–46] cells per mL and 1483 [999–2217] ng/mL, respectively. Conclusions We observed early in the course of COVID-19 ARDS high VD/VT in association with biological markers of endothelial damage and thrombosis. High VD/VT can be explained by high PEEP settings and added instrumental dead space, with a possible associated role of COVID-19-triggered pulmonary microvascular endothelial damage and microthrombotic process.


1995 ◽  
Vol 5 (6) ◽  
Author(s):  
M.H.Th. Reinges ◽  
W.A. Kaiser ◽  
W.D. Miersch ◽  
J. Vogel ◽  
M. Reiser

2008 ◽  
Vol 61 (1) ◽  
pp. 103-116 ◽  
Author(s):  
Hong Jung ◽  
Kyunghyun Sung ◽  
Krishna S. Nayak ◽  
Eung Yeop Kim ◽  
Jong Chul Ye

Author(s):  
Dailin Rong ◽  
Weimin Liu ◽  
Sichi Kuang ◽  
Sidong Xie ◽  
Zhanhong Chen ◽  
...  

Author(s):  
Dina G. Abdelzaher ◽  
Mahmoud Abdelatif ◽  
Waleed M. Thabet ◽  
Amr M. Elshafei ◽  
Magda M. Shady

Author(s):  
Jianli Li ◽  
Saixian Ma ◽  
Xiujie Chang ◽  
Songxu Ju ◽  
Meng Zhang ◽  
...  

AbstractThe study aimed to investigate the efficacy of PCV-VG combined with individual PEEP during laparoscopic surgery in the Trendelenburg position. 120 patients were randomly divided into four groups: VF group (VCV plus 5cmH2O PEEP), PF group (PCV-VG plus 5cmH2O PEEP), VI group (VCV plus individual PEEP), and PI group (PCV-VG plus individual PEEP). Pmean, Ppeak, Cdyn, PaO2/FiO2, VD/VT, A-aDO2 and Qs/Qt were recorded at T1 (15 min after the induction of anesthesia), T2 (60 min after pneumoperitoneum), and T3 (5 min at the end of anesthesia). The CC16 and IL-6 were measured at T1 and T3. Our results showed that the Pmean was increased in VI and PI group, and the Ppeak was lower in PI group at T2. At T2 and T3, the Cdyn of PI group was higher than that in other groups, and PaO2/FiO2 was increased in PI group compared with VF and VI group. At T2 and T3, A-aDO2 of PI and PF group was reduced than that in other groups. The Qs/Qt was decreased in PI group compared with VF and VI group at T2 and T3. At T2, VD/VT in PI group was decreased than other groups. At T3, the concentration of CC16 in PI group was lower compared with other groups, and IL-6 level of PI group was decreased than that in VF and VI group. In conclusion, the patients who underwent laparoscopic surgery, PCV-VG combined with individual PEEP produced favorable lung mechanics and oxygenation, and thus reducing inflammatory response and lung injury.Clinical Trial registry: chictr.org. identifier: ChiCTR-2100044928


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