Therapy-Induced Changes in Head and Neck

2015 ◽  
pp. 95-111 ◽  
Author(s):  
Michael M. Lell
Keyword(s):  
Head And Neck ◽  
Induced Changes

Oral Sequelae of Head and Neck Radiotherapy

2003 ◽  
Vol 14 (3) ◽  
pp. 199-212 ◽  
Author(s):  
A. Vissink ◽  
J. Jansma ◽  
F.K.L. Spijkervet ◽  
F.R. Burlage ◽  
R.P. Coppes
Keyword(s):  
Head And Neck ◽  
Neck Region ◽  
Normal Tissues ◽  
Radiation Caries ◽  
Temporomandibular Joints ◽  
Clinical Consequences ◽  
Radiation Induced ◽  
Heavy Burden ◽  
Effects Of Radiation ◽  
Induced Changes

In addition to anti-tumor effects, ionizing radiation causes damage in normal tissues located in the radiation portals. Oral complications of radiotherapy in the head and neck region are the result of the deleterious effects of radiation on, e.g., salivary glands, oral mucosa, bone, dentition, masticatory musculature, and temporomandibular joints. The clinical consequences of radiotherapy include mucositis, hyposalivation, taste loss, osteoradionecrosis, radiation caries, and trismus. Mucositis and taste loss are reversible consequences that usually subside early post-irradiation, while hyposalivation is normally irreversible. Furthermore, the risk of developing radiation caries and osteoradionecrosis is a life-long threat. All these consequences form a heavy burden for the patients and have a tremendous impact on their quality of life during and after radiotherapy. In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.

Radiation Therapy-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients

2014 ◽  
Vol 90 (1) ◽  
pp. S781-S782
Author(s):  
P. Widlak ◽  
K. Jelonek ◽  
M. Ros ◽  
M. Pietrowska ◽  
T. Rutkowski ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Induced Changes

RADIATION-INDUCED CHANGES OF ADC VALUES FOR HEAD AND NECK ORGANS

2017 ◽  
Vol 124 (1) ◽  
pp. e27-e28
Author(s):  
H. SHIMAMOTO ◽  
I. SUMIDA ◽  
M. MAJIMA ◽  
Y. SENDA ◽  
A. USAMI ◽  
...  
Keyword(s):  
Head And Neck ◽  
Adc Values ◽  
Radiation Induced ◽  
Induced Changes

scholarly journals Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1324 ◽  
Author(s):  
Balázs ◽  
Kis ◽  
Badie ◽  
Bogdándi ◽  
Candéias ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Peripheral Blood ◽  
Blood Cells ◽  
Local Therapy ◽  
Peripheral Blood Cells ◽  
Immune Parameters ◽  
Induced Changes

Though radiotherapy is a local therapy, it has systemic effects mainly influencing immune and inflammation processes. This has important consequences in the long-term prognosis and therapy individualization. Our objective was to investigate immune and inflammation-related changes in the peripheral blood of head and neck cancer patients treated with radiotherapy. Peripheral blood cells, plasma and blood cell-derived RNA were isolated from 23 patients before and at two time points after radiotherapy and cellular immune parameters, plasma protein changes and gene expression alterations were studied. Increased regulatory T cells and increased CTLA4 and PD-1 expression on CD4 cells indicated an immune suppression induced by the malignant condition, which was accentuated by radiotherapy. Circulating dendritic cells were strongly elevated before treatment and were not affected by radiotherapy. Decreased endoglin levels in the plasma of patients before treatment were further decreased by radiotherapy. Expression of the FXDR, SESN1, GADD45, DDB2 and MDM2 radiation-response genes were altered in the peripheral blood cells of patients after radiotherapy. All changes were long-lasting, detectable one month after radiotherapy. In conclusion we demonstrated radiotherapy-induced changes in systemic immune parameters of head and neck cancer patients and proposed markers suitable for patient stratification worth investigating in larger patient cohorts.

scholarly journals Radiation-Induced Changes in Serum Lipidome of Head and Neck Cancer Patients

2014 ◽  
Vol 15 (4) ◽  
pp. 6609-6624 ◽  
Author(s):  
Karol Jelonek ◽  
Monika Pietrowska ◽  
Malgorzata Ros ◽  
Adam Zagdanski ◽  
Agnieszka Suchwalko ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Radiation Induced ◽  
Induced Changes

Treatment-induced changes of lymphocyte subsets in patients with adenoid cystic carcinoma of the head and neck

2019 ◽  
Vol 276 (5) ◽  
pp. 1465-1473 ◽  
Author(s):  
S. S. Jeske ◽  
S. E. Weissinger ◽  
J. A. Veit ◽  
C. Brunner ◽  
U. Huber ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Head And Neck ◽  
Lymphocyte Subsets ◽  
Adenoid Cystic ◽  
Induced Changes

scholarly journals Phase Angle as an Objective and Predictive Factor of Radiotherapy-induced Changes in Body Composition of Male Patients With Head and Neck Cancer

In Vivo ◽  
2019 ◽  
Vol 33 (5) ◽  
pp. 1645-1651 ◽  
Author(s):  
TERESA MAŁECKA-MASSALSKA ◽  
TOMASZ POWRÓZEK ◽  
MONIKA PRENDECKA ◽  
RADOSŁAW MLAK ◽  
GRZEGORZ SOBIESZEK ◽  
...  
Keyword(s):  
Body Composition ◽  
Head And Neck Cancer ◽  
Head And Neck ◽  
Phase Angle ◽  
Neck Cancer ◽  
Predictive Factor ◽  
Male Patients ◽  
Induced Changes
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