Therapy-Induced Changes in Head and Neck

Author(s):  
Michael M. Lell
2003 ◽  
Vol 14 (3) ◽  
pp. 199-212 ◽  
Author(s):  
A. Vissink ◽  
J. Jansma ◽  
F.K.L. Spijkervet ◽  
F.R. Burlage ◽  
R.P. Coppes

In addition to anti-tumor effects, ionizing radiation causes damage in normal tissues located in the radiation portals. Oral complications of radiotherapy in the head and neck region are the result of the deleterious effects of radiation on, e.g., salivary glands, oral mucosa, bone, dentition, masticatory musculature, and temporomandibular joints. The clinical consequences of radiotherapy include mucositis, hyposalivation, taste loss, osteoradionecrosis, radiation caries, and trismus. Mucositis and taste loss are reversible consequences that usually subside early post-irradiation, while hyposalivation is normally irreversible. Furthermore, the risk of developing radiation caries and osteoradionecrosis is a life-long threat. All these consequences form a heavy burden for the patients and have a tremendous impact on their quality of life during and after radiotherapy. In this review, the radiation-induced changes in healthy oral tissues and the resulting clinical consequences are discussed.


2014 ◽  
Vol 90 (1) ◽  
pp. S781-S782
Author(s):  
P. Widlak ◽  
K. Jelonek ◽  
M. Ros ◽  
M. Pietrowska ◽  
T. Rutkowski ◽  
...  

2017 ◽  
Vol 124 (1) ◽  
pp. e27-e28
Author(s):  
H. SHIMAMOTO ◽  
I. SUMIDA ◽  
M. MAJIMA ◽  
Y. SENDA ◽  
A. USAMI ◽  
...  

Cancers ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 1324 ◽  
Author(s):  
Balázs ◽  
Kis ◽  
Badie ◽  
Bogdándi ◽  
Candéias ◽  
...  

Though radiotherapy is a local therapy, it has systemic effects mainly influencing immune and inflammation processes. This has important consequences in the long-term prognosis and therapy individualization. Our objective was to investigate immune and inflammation-related changes in the peripheral blood of head and neck cancer patients treated with radiotherapy. Peripheral blood cells, plasma and blood cell-derived RNA were isolated from 23 patients before and at two time points after radiotherapy and cellular immune parameters, plasma protein changes and gene expression alterations were studied. Increased regulatory T cells and increased CTLA4 and PD-1 expression on CD4 cells indicated an immune suppression induced by the malignant condition, which was accentuated by radiotherapy. Circulating dendritic cells were strongly elevated before treatment and were not affected by radiotherapy. Decreased endoglin levels in the plasma of patients before treatment were further decreased by radiotherapy. Expression of the FXDR, SESN1, GADD45, DDB2 and MDM2 radiation-response genes were altered in the peripheral blood cells of patients after radiotherapy. All changes were long-lasting, detectable one month after radiotherapy. In conclusion we demonstrated radiotherapy-induced changes in systemic immune parameters of head and neck cancer patients and proposed markers suitable for patient stratification worth investigating in larger patient cohorts.


2014 ◽  
Vol 15 (4) ◽  
pp. 6609-6624 ◽  
Author(s):  
Karol Jelonek ◽  
Monika Pietrowska ◽  
Malgorzata Ros ◽  
Adam Zagdanski ◽  
Agnieszka Suchwalko ◽  
...  

2019 ◽  
Vol 276 (5) ◽  
pp. 1465-1473 ◽  
Author(s):  
S. S. Jeske ◽  
S. E. Weissinger ◽  
J. A. Veit ◽  
C. Brunner ◽  
U. Huber ◽  
...  

In Vivo ◽  
2019 ◽  
Vol 33 (5) ◽  
pp. 1645-1651 ◽  
Author(s):  
TERESA MAŁECKA-MASSALSKA ◽  
TOMASZ POWRÓZEK ◽  
MONIKA PRENDECKA ◽  
RADOSŁAW MLAK ◽  
GRZEGORZ SOBIESZEK ◽  
...  

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