Esophageal Manometry and Gastroesophageal Reflux Monitoring

2012 ◽  
pp. 323-327
Author(s):  
Karin Aksglæde ◽  
Per Thommesen ◽  
Peter Funch-Jensen
Keyword(s):  
Gastroesophageal Reflux ◽  
Esophageal Manometry

Gastroesophageal Reflux Reported on Esophagram Does Not Correlate with pH Monitoring and High-resolution Esophageal Manometry

2014 ◽  
Vol 80 (10) ◽  
pp. 1026-1029 ◽  
Author(s):  
Derek Serna-Gallegos ◽  
Benjamin Basseri ◽  
Vahak Bairamian ◽  
Mark Pimentel ◽  
Harmik J. Soukiasian
Keyword(s):  
High Resolution ◽  
Gastroesophageal Reflux ◽  
Predictive Value ◽  
Esophageal Manometry ◽  
Ph Monitoring ◽  
False Negative ◽  
Structural Defects ◽  
Positive Finding ◽  
False Positive Finding ◽  
Negative Finding

Gastroesophageal reflux disease (GERD) is commonly reported on esophagram (UGI) studies. The correlation of findings suggestive of GERD on UGI with pH monitoring and high-resolution esophageal manometry (HRM) studies is unclear. We investigate the correlation between reflux on UGI with the findings on pH studies and HRM. Subjects completed a symptom questionnaire before their scheduled study. Data from pH and HRM studies were compared with findings of the UGI. Sixty-five patients were evaluated. Reflux was reported on UGI in 19 of 65 (29.2%). Thirty-six patients had both UGI and pH studies; 22 of 36 (61.1%) had reflux on pH studies. UGI had a false-negative finding in 11 of 20 (55%) with no radiographic evidence of reflux. There was a false-positive finding in five of 16 (31.2%) patients on UGI. There was concordance in 11 of 36 (30.5%). Sixty-three patients had both UGI and HRM; there was positive concordance in eight of 63 (12.7%). Using pH monitoring as the gold standard for GERD, sensitivity was 0.50, specificity 0.64, positive predictive value 0.68, and negative predictive value 0.45 for reflux on UGI. The correlation between reflux reported on UGI and 24-hour pH monitoring is poor. Esophagram (UGI) should be reserved for defining structural defects in the esophagus and not reflux.

Esophageal manometry and 24-hour pH testing in the management of gastroesophageal reflux patients

1997 ◽  
Vol 174 (6) ◽  
pp. 634-638 ◽  
Author(s):  
Galen Perdikis ◽  
Richard J. Lund ◽  
Ronald A. Hinder ◽  
Thomas R. McGinn ◽  
Charles J. Filipi ◽  
...  
Keyword(s):  
Gastroesophageal Reflux ◽  
Esophageal Manometry

Effect of hiatal hernia on esophageal manometry and pH-metry in gastroesophageal reflux disease

1995 ◽  
Vol 40 (12) ◽  
pp. 2724-2730 ◽  
Author(s):  
Panagiotis Kasapidis ◽  
John Sophocles Vassilakis ◽  
George Tzovaras ◽  
Emmanuel Chrysos ◽  
Evaghelos Xynos
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Hiatal Hernia ◽  
Reflux Disease ◽  
Esophageal Manometry ◽  
Ph Metry

scholarly journals The importance of functional diagnostics in determining the cause of antisecretary therapy inefficiency in a patient with heartburn: clinical observation

2021 ◽  
pp. 46-53
Author(s):  
E. V. Barkalova ◽  
D. N. Andreev ◽  
M. A. Ovsepian
Keyword(s):  
Differential Diagnosis ◽  
High Resolution ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Research Methods ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Reflux Disease ◽  
Esophageal Manometry ◽  
Clinical Observation

One of the main symptoms of gastroesophageal reflux disease is heartburn, for the relief of which proton pump inhibitors are traditionally prescribed. However, there are frequent cases of heartburn, refractory to antisecretory therapy, when there is no complete relief of the symptom or only a partial clinical effect. The reason for an unsatisfactory response may be the functional genesis of heartburn. The purpose of the presented clinical observation is to demonstrate the heterogeneity of patients with heartburn, the role of functional research methods in the differential diagnosis of various conditions that accompany this symptom. A 42-year-old patient was admitted for an additional clinical examination with complaints of heartburn refractory to antisecretory therapy, which included high-resolution esophageal manometry, 24-hours pH-impedance. The manometric assessment of the structure and function of the lower esophageal sphincter, as well as the contractility of the thoracic esophagus, revealed no violations. The data of 24-hours pH-impedance demonstrated the absence of pathological reflux and the association of active symptoms with refluxes, which determined the functional nature of heartburn and explained the ineffectiveness of treatment with proton pump inhibitors. Heartburn can be functional in  nature and significantly reduce the  quality of  life of  patients. Functional heartburn requires different management tactics from gastroesophageal reflux disease, which is based on an adequate differential diagnosis, including functional research methods such as high-resolution esophageal manometry and 24-hours pH-impedance measurement, which allow to exclude other conditions accompanied by similar symptoms. 

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