MRI-Guided Thermal Ablation Techniques

2012 ◽  
pp. 253-269
Author(s):  
R. Jason Stafford ◽  
Kamran Ahrar
Keyword(s):  
Thermal Ablation ◽  
Ablation Techniques ◽  
Mri Guided

Robot-assisted MRI-guided prostatic interventions

Robotica ◽  
2009 ◽  
Vol 28 (2) ◽  
pp. 215-234 ◽  
Author(s):  
Andrew A. Goldenberg ◽  
John Trachtenberg ◽  
Yang Yi ◽  
Robert Weersink ◽  
Marshall S. Sussman ◽  
...  
Keyword(s):  
Thermal Ablation ◽  
Pulse Sequences ◽  
Robot Assisted ◽  
Surgical Ablation ◽  
Image Guided ◽  
Surgical Tool ◽  
Mri Environment ◽  
Focal Ablation ◽  
Mri Guided ◽  
Magnetic Resonance Imaging Mri

SUMMARYThis paper reports on recent progress made toward the development of a new magnetic resonance imaging (MRI)-compatible robot-assisted surgical system for closed-bore image-guided prostatic interventions: thermal ablation, radioactive seed implants (brachytherapy), and biopsy. Each type of intervention will be performed with a different image-guided, robot-based surgical tool mounted on the same MRI-guided robot through a modular trocar. The first stage of this development addresses only laser-based focal ablation. The robot mechanical structure, modular surgical trocar, control architecture, and current stage of performance evaluation in the MRI environment are presented. The robot actuators are ultrasonic motors. A methodology of using such motors in the MRI environment is presented. The robot prototype with surgical ablation tool is undergoing tests on phantoms in the MRI bore. The tests cover MRI compatibility, image visualization, robot accuracy, and thermal mapping. To date, (i) the images are artifact- and noise-free for certain scanning pulse sequences; (ii) the robot tip positioning error is less than 1.2 mm even at positions closer than 0.3 m from the MRI isocenter; (iii) penetration toward the target is image-monitored in near-real time; and (iv) thermal ablation and temperature mapping are achieved using a laser delivered on an optical fiber and MRI, respectively.

scholarly journals Percutaneous Ablation-Induced Immunomodulation in Hepatocellular Carcinoma

2020 ◽  
Vol 21 (12) ◽  
pp. 4398 ◽  
Author(s):  
Lucile Dumolard ◽  
Julien Ghelfi ◽  
Gael Roth ◽  
Thomas Decaens ◽  
Zuzana Macek Jilkova
Keyword(s):  
Hepatocellular Carcinoma ◽  
Radiofrequency Ablation ◽  
Thermal Ablation ◽  
Microwave Ablation ◽  
Treatment Options ◽  
Ablation Techniques ◽  
High Rate ◽  
Percutaneous Ablation ◽  
Ablative Therapies ◽  
Immune Changes

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related deaths worldwide and its incidence is rising. Percutaneous locoregional therapies, such as radiofrequency ablation and microwave ablation, are widely used as curative treatment options for patients with small HCC, but their effectiveness remains restricted because of the associated high rate of recurrence, occurring in about 70% of patients at five years. These thermal ablation techniques have the particularity to induce immunomodulation by destroying tumours, although this is not sufficient to raise an effective antitumour immune response. Ablative therapies combined with immunotherapies could act synergistically to enhance antitumour immunity. This review aims to understand the different immune changes triggered by radiofrequency ablation and microwave ablation as well as the interest in using immunotherapies in combination with thermal ablation techniques as a tool for complementary immunomodulation.

Sign in / Sign up

Export Citation Format

Share Document