Imaging Features of Granulomatosis with Polyangiitis (Wegener’s)

2011 ◽  
pp. 259-278
Author(s):  
Stéphane Silvera ◽  
Estelle Palangié ◽  
Loîc Guillevin ◽  
Lotfi Hendaoui ◽  
Paul Legmann
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Imaging Features

scholarly journals Eosinophilic Granulomatosis with Polyangiitis: Diagnostic Dilemmas

2018 ◽  
Vol 15 (1) ◽  
pp. 63-68
Author(s):  
Delia Tulbă ◽  
Răzvan Adrian Ionescu ◽  
Daniela Gologanu ◽  
Marius Ioan Balea ◽  
Simona Caraiola
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Histopathological Examination ◽  
Systemic Vasculitis ◽  
Transbronchial Biopsy ◽  
Eosinophilic Granulomatosis With Polyangiitis ◽  
Imaging Features ◽  
Necrotizing Vasculitis ◽  
Tissue Eosinophilia ◽  
Lung Abnormalities ◽  
Eosinophilic Granulomatosis

AbstractIntroduction. Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as Churg-Strauss syndrome, is a systemic vasculitis of the small vessels that often associates asthma and blood/tissue eosinophilia.Case presentation. A 58-year-old woman was admitted to our hospital for progressive exertional dyspnea. She had been diagnosed with asthma three years earlier. Recent multiple thoracic computed tomography scans displayed non-fixed interstitial lung abnormalities, whereas the infectious workup (HIV, parasites) was negative.On admission, the clinical examination noted prolonged expiratory phase. Paraclinical tests revealed biological inflammatory syndrome, eosinophilia, polyclonal hypergammaglobulinemia, elevated total IgE level, negative anti-neutrophil cytoplasmic antibodies and proteinuria of nephritic pattern.The pulmonary evaluation reconfirmed the obstructive ventilatory dysfunction and interstitial lung abnormalities - interlobular septal thickening and diffuse ground-glass opacification. The histopathological examination of a transbronchial biopsy specimen identified leukocytoclastic necrotizing vasculitis and tissue eosinophilia.Provided the clinical and paraclinical setting, specifically the asthma, blood and extravascular eosinophilia, paranasal sinus abnormalities, non-fixed pulmonary infiltrates and the histopathologically confirmed necrotizing vasculitis, the diagnosis of EGPA seemed appropriate.Conclusion. In the absence of diagnostic criteria, EGPA diagnosis is often challenging. Although certain clinical and imaging features could assist the diagnosis, biopsy remains the diagnostic gold standard.In the setting of lung involvement, open lung biopsy is usually required for EGPA histopathological proof, but few cases diagnosed by transbronchial biopsy have been reported. This method often identifies discrete, nonspecific lesions or an incomplete spectrum of pathognomonic abnormalities but has the advantage of minimal invasivity that justifies its use as an alternative diagnostic technique.

scholarly journals Breast involvement in granulomatosis with polyangiitis: a case report

2021 ◽  
Vol 52 (1) ◽  
Author(s):  
Bhavya Basetti ◽  
Gokulakrishnan Periakaruppan ◽  
Arunan Murali ◽  
Bhawna Dev ◽  
Prabhu Radhan Radhakrishnan ◽  
...  
Keyword(s):  
Breast Lesion ◽  
Granulomatosis With Polyangiitis ◽  
Immunosuppressive Treatment ◽  
Imaging Features ◽  
Multisystem Disorder ◽  
Multisystem Disease ◽  
Histopathological Correlation ◽  
Multisystem Involvement ◽  
Immune Mediated ◽  
The Right

Abstract Background Granulomatosis with polyangiitis (GPA) previously known as Wegener's granulomatosis is a rare complex immune-mediated disease and a multisystem disorder with varying presentations where many of the imaging features of GPA overlap with those of other diseases, and hence its diagnosis can be challenging. Case presentation Here we report a case of a 48-year-old female who presented with complaints of hemoptysis, difficulty in speech, bilateral progressive hearing loss and, a palpable lump in the right breast. The case was initially misdiagnosed as breast carcinoma but biopsy proved to be GPA. Here we present the multisystem manifestations of GPA involving the head and neck, breast, lungs, spleen with involvement of the breast being very rare. The breast lesion showed improvement with steroids on follow-up. Conclusions GPA is a multisystem disease and though breast lesions in GPA are rare, a thorough knowledge about this uncommon manifestation is required and clinical, radiological, and histopathological correlation is of utmost importance in the evaluation of a breast lesion in cases of multisystem involvement to avoid unnecessary surgeries. The differential diagnosis of breast tumors should include such rare conditions that can sometimes mimic breast cancer. Early diagnosis and initiation of the immunosuppressive treatment help in a better prognosis of the disease.

Clinical and Imaging Features of Lacrimal Gland Involvement in Granulomatosis with Polyangiitis

Ophthalmology ◽  
2015 ◽  
Vol 122 (10) ◽  
pp. 2125-2129 ◽  
Author(s):  
Lee Teak Tan ◽  
Indran Davagnanam ◽  
Hazlita Isa ◽  
Geoffrey E. Rose ◽  
David H. Verity ◽  
...  
Keyword(s):  
Lacrimal Gland ◽  
Granulomatosis With Polyangiitis ◽  
Imaging Features

Clinical and Imaging Features Predictive of Orbital Granulomatosis with Polyangiitis and the Risk of Systemic Involvement

Ophthalmology ◽  
2014 ◽  
Vol 121 (6) ◽  
pp. 1304-1309 ◽  
Author(s):  
Lee Teak Tan ◽  
Indran Davagnanam ◽  
Hazlita Isa ◽  
Simon R. Taylor ◽  
Geoffrey E. Rose ◽  
...  
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Imaging Features ◽  
Systemic Involvement

scholarly journals Head and neck manifestations of granulomatosis with polyangiitis

2020 ◽  
pp. 20200914
Author(s):  
Jon O. Cleary ◽  
Nishanth Sivarasan ◽  
Christian Burd ◽  
Steve E. J. Connor
Keyword(s):  
Head And Neck ◽  
Granulomatosis With Polyangiitis ◽  
Significant Proportion ◽  
Treatment Resistance ◽  
Clinical History ◽  
Imaging Features ◽  
Upper Aerodigestive Tract ◽  
Mri Findings ◽  
Pictorial Review ◽  
Autoimmune Condition

Granulomatosis with polyangiitis is a rare autoimmune condition which causes respiratory tract granulomas, small to medium vessel vasculitis and renal disease. Head and neck manifestations are some of the most common presentations of the condition, with a significant proportion of patients experiencing sinonasal disease alone. The recognition of suggestive imaging findings, in combination with clinical history and serology, aids the diagnosis and appropriate treatment. This pictorial review describes and illustrates the head and neck imaging features of granulomatosis with polyangiitis, highlighting the range of CT and MRI findings of upper aerodigestive tract, orbital and skull-base disease. Recognition of the radiological appearances is of importance, since clinical presentations may be non-specific and limited disease may have negative serology. Imaging features may overlap with other pathologies so important differential diagnoses will be considered, and these are particularly relevant in the context of treatment resistance.

scholarly journals COVID19 pneumonia with cavitation and cystic lung changes: multi-detector computed tomography spectrum of a gamut of etiologies

BJR|Open ◽  
2021 ◽  
Vol 3 (1) ◽  
pp. 20210007
Author(s):  
Arunima Aggarwal ◽  
Anupama Tandon ◽  
Shuchi Bhatt ◽  
Anivita Aggarwal ◽  
Saloni Dagar ◽  
...  
Keyword(s):  
Cystic Lesion ◽  
Granulomatosis With Polyangiitis ◽  
Pulmonary Nodules ◽  
Chest Ct ◽  
Imaging Features ◽  
Diagnostic Dilemma ◽  
Cystic Lung ◽  
Pictorial Review ◽  
Pulmonary Cysts ◽  
Multi Detector Computed Tomography

The COVID19 pandemic since its beginning in March 2020, continues to wreak havoc causing great morbidity and mortality with each passing day. Ample literature is now available describing the imaging features of COVID19 infection; however, there is still a paucity of knowledge on the various causes of pulmonary cavitation and cystic lesions which can be associated with the virus albeit uncommonly. Cavitation in a COVID19 positive patient could be a consequence of the infection itself or a manifestation of sinister etiologies like coinfection with bacterial, fungal or mycobacterial pathogens, or incidental malignancy/metastasis. It could also be a result of multiple cavitating pulmonary nodules as a manifestation of septic emboli and infarct, Granulomatosis with polyangiitis or rheumatoid arthritis creating a diagnostic dilemma. Similarly, the causes of cystic air spaces on chest CT in COVID19 patient can be varied, either primarily due to the infection itself or secondary to coexistent cystic bronchiectasis, emphysema, interstitial lung disease or mechanical ventilation-associated barotrauma as well as complicated pulmonary cysts. Through this pictorial review, we aim to highlight these uncommon imaging manifestations of COVID19 and educate the reader regarding the various causes, MDCT features and differentials to be considered while approaching a cavity/cystic lesion amidst this pandemic.

Imaging Features of Nontumorous Conditions Involving the Trachea and Main-stem Bronchi

2002 ◽  
Vol 47 (3) ◽  
pp. 269
Author(s):  
Kyung Nyeo Jeon ◽  
Duk Sik Kang ◽  
Kyung Soo Bae
Keyword(s):  
Main Stem ◽  
Imaging Features

PEMBELAJARAN SIMULASI PENCITRAAN CT DENGAN MENGGUNAKAN PRINSIP REKONSTRUKSI CITRA DALAM SOFTWARE MATLAB

2015 ◽  
Vol 8 (3) ◽  
pp. 161
Author(s):  
Samuel Gideon
Keyword(s):  
Image Reconstruction ◽  
Ct Imaging ◽  
The Body ◽  
Reconstruction Technique ◽  
Imaging Features ◽  
Back Projection ◽  
Cross Sectional ◽  
Low Contrast ◽  
Image Reconstruction Technique ◽  
Imaging Algorithms

This research was conducted as a learning alternatives for study of CT (computed tomograpghy) imaging using image reconstruction technique which are inversion matrix, back projection and filtered back projection. CT imaging can produce images of objects that do not overlap. Objects more easily distinguishable although given the relatively low contrast. The image is generated on CT imaging is the result of reconstruction of the original object. Matlab allows us to create and write imaging algorithms easily, easy to undersand and gives applied and exciting other imaging features. In this study, an example cross-sectional image recon-struction performed on the body of prostate tumors using. With these methods, medical prac-titioner (such as oncology clinician, radiographer and medical physicist) allows to simulate the reconstruction of CT images which almost resembles the actual CT visualization techniques.Keywords : computed tomography (CT), image reconstruction, Matlab

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