Kappa Opioid Agonist-Induced Diuresis: Characteristics, Mechanisms, and Beyond

2020 ◽  
Author(s):  
Saadet Inan
Keyword(s):  
Opioid Agonist ◽  
Kappa Opioid ◽  
Kappa Opioid Agonist

kappa-Opioid agonist inhibition of osmotically induced AVP release: preferential action at hypothalamic sites

1996 ◽  
Vol 270 (2) ◽  
pp. E367-E372 ◽  
Author(s):  
N. F. Rossi ◽  
D. P. Brooks
Keyword(s):  
Potent Inhibitor ◽  
Opiate Receptors ◽  
Opioid Antagonist ◽  
Posterior Pituitary ◽  
Opioid Agonist ◽  
Kappa Opioid ◽  
Water Diuresis ◽  
Kappa Agonist ◽  
Opioid Agonists ◽  
Kappa Opioid Agonist

Although several studies indicate that kappa-opioid agonists induce a water diuresis by inhibiting vasopressin (AVP) secretion, the locus of the kappa-receptors (neurohypophysial vs. hypothalamic) responsible for this effect remains unclear. We have ascertained the effect of the selective kappa-agonist BRL-52656 (BRL) on AVP secretion by using compartmentalized rat hypothalamoneurohypophysial explants in culture. When applied to the hypothalamus, nanomolar concentrations of BRL inhibited osmotically stimulated AVP secretion. This response was blocked by the highly selective kappa-opioid antagonist nor-binaltorphimine (BNI). However, osmotically stimulated AVP release was suppressed at the neurohypophysial site only by 100 nM BRL and was not reversed by BNI but only by naloxone. This dose of BRL, administered to the posterior pituitary compartment, did not appear to act by the agonist gaining access to hypothalamic kappa-opiate receptors, because BNI added to the hypothalamus failed to prevent the inhibition of AVP secretion. The data demonstrate that BRL is a potent inhibitor of osmotically stimulated AVP secretion via activation of kappa-opiate receptors within the hypothalamus, but that higher concentrations of the drug may also stimulate non-kappa-neurohypophysial opiate receptors that suppress AVP release.

Synthesis of tritium labelled (-)-U50,488, a selective kappa opioid agonist

1989 ◽  
Vol 27 (5) ◽  
pp. 577-582 ◽  
Author(s):  
Andrew Thurkauf ◽  
Brian De Gosta ◽  
Kenner C. Rice
Keyword(s):  
Opioid Agonist ◽  
Kappa Opioid ◽  
Kappa Opioid Agonist

scholarly journals The Kappa-Opioid Agonist U69,593 Blocks Cocaine-Induced Enhancement of Brain Stimulation Reward

2008 ◽  
Vol 64 (11) ◽  
pp. 982-988 ◽  
Author(s):  
Hilarie C. Tomasiewicz ◽  
Mark S. Todtenkopf ◽  
Elena H. Chartoff ◽  
Bruce M. Cohen ◽  
William A. Carlezon
Keyword(s):  
Brain Stimulation ◽  
Brain Stimulation Reward ◽  
Opioid Agonist ◽  
Kappa Opioid ◽  
Kappa Opioid Agonist
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