Targeting Bile Acid-Activated Receptors in Bariatric Surgery

2019 ◽  
pp. 359-378 ◽  
Author(s):  
Lili Ding ◽  
Zhipeng Fang ◽  
Yanjun Liu ◽  
Eryun Zhang ◽  
Tracy Huang ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Bile Acid

scholarly journals Bile acid signaling and bariatric surgery

2017 ◽  
Vol 1 (4) ◽  
pp. 208-213 ◽  
Author(s):  
Jingyan Tian ◽  
Silvia Huang ◽  
Siming Sun ◽  
Lili Ding ◽  
Eryun Zhang ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Bile Acid

scholarly journals Bile acid, glucose, lipid profile, and liver enzyme changes in prediabetic patients 1 year after sleeve gastrectomy

BMC Surgery ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Tsz Kin Mak ◽  
Shifang Huang ◽  
Bingsheng Guan ◽  
Hoyin Au ◽  
Tsz Hong Chong ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Sleeve Gastrectomy ◽  
Bile Acid ◽  
Liver Enzyme ◽  
Total Bile Acid ◽  
First Year ◽  
Lipid Levels ◽  
Post Surgery ◽  
The Impact ◽  
Enzyme Changes

Abstract Background Few articles have studied individuals with prediabetes after sleeve gastrectomy. Bile acid and lipid levels remain inconsistent in postbariatric patients. The purpose of this study was to explore bile acid, glucose, lipid, and liver enzyme changes in patients with different diabetes statuses who underwent sleeve gastrectomy. The impact of bariatric surgery and its potential benefits for prediabetic patients was also discussed. Methods A total of 202 overweight and obese patients who underwent bariatric surgery in our hospital between January 2016 and October 2018 were retrospectively reviewed. Patients were divided into prediabetes (n = 32), nondiabetes (n = 144), and diabetes (n = 26) groups and analysed. Glucose and lipid data were collected from medical records at baseline and at each follow-up visit. Result Significant improvements in body weight, glucose and lipid levels, and liver enzymes (P ≤ 0.05) in prediabetic patients were found throughout the first year postoperatively. Improvement in glycaemic control was first seen one month postoperatively, followed by persistent improvement in the next 12 months. Total bile acid (TBA) decreased, which was associated with ALT improvement in prediabetic patients 1-year post-surgery. There were no significant differences in HbA1c, glucose, or triglycerides (TGs) between prediabetic and T2DM patients or between prediabetic and nondiabetic patients at 12 months post-surgery. Conclusion LSG is highly effective at interfering with glucose and lipid levels as well as total bile acid levels in prediabetic patients in the first year postoperatively. Thus, LSG is indeed an alternative for overweight and obese prediabetic patients.

Effects of Bariatric Surgery on Serum Bile Acid Composition and Conjugation in a Diabetic Rat Model

2016 ◽  
Vol 26 (10) ◽  
pp. 2384-2392 ◽  
Author(s):  
Qunzheng Wu ◽  
Xiang Zhang ◽  
Mingwei Zhong ◽  
Haifeng Han ◽  
Shaozhuang Liu ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Bile Acid ◽  
Acid Composition ◽  
Rat Model ◽  
Diabetic Rat ◽  
Serum Bile Acid ◽  
Diabetic Rat Model

scholarly journals Impact of Fibroblast Growth Factors 19 and 21 in Bariatric Metabolism

2017 ◽  
Vol 35 (3) ◽  
pp. 191-196 ◽  
Author(s):  
Ashley Patton ◽  
Farooq H. Khan ◽  
Rohit Kohli
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Bile Acid ◽  
Health Condition ◽  
Metabolic Effects ◽  
Peroxisome Proliferator ◽  
Fibroblast Growth ◽  
Long Term Effects ◽  
Peroxisome Proliferator Activated Receptor ◽  
Distal Small Intestine

Background: Bariatric surgery is a popular and effective therapeutic intervention for obesity, which is an abnormal health condition that is prevalent worldwide. Metabolic improvements that precede weight loss after bariatric surgery may be mediated, in part, through the fibroblast growth factor (FGF) 15/19 and FGF21 signaling pathways. Both FGF15/19 and FGF21 are hormone-like members of the FGF family and exert their metabolic effects in an endocrine manner. Enhanced bile acid recycling after bariatric surgery leads to increased circulating levels of FGF15/19 in the distal small intestine. Synthesis of FGF21 is upregulated predominately in the fasting state through peroxisome proliferator-activated receptor pathways and to a lesser extent by FGF15/19. Key Messages: The biological functions of FGF15/19 and FGF21 are diverse and complicated. The tissue targeted effects of FGF15/19 and FGF21 of importance after bariatric surgery include the regulation of hepatic bile acid biosynthesis and ketogenesis as well as thermogenesis in adipose tissue, respectively. Furthermore, FGF15/19 and FGF21 function to regulate carbohydrate and lipid metabolism. Conclusion: The long-term effects of bariatric surgery on weight loss are undisputable. However, the mechanism for improvements in glucose and lipid homeostasis observed shortly after bariatric surgery is less understood. This review article attempts to describe the known metabolic effects of FGF15/19 and FGF21 that may potentiate these improvements after bariatric surgery.

scholarly journals What Can We Learn From Mouse Models About Bile Acid–Mediated Changes After Bariatric Surgery?

2019 ◽  
Vol 157 (1) ◽  
pp. 4-8 ◽  
Author(s):  
Emma Rose McGlone ◽  
Tricia Tan ◽  
Stephen R. Bloom ◽  
Julian R.F. Walters
Keyword(s):  
Bariatric Surgery ◽  
Bile Acid ◽  
Mouse Models

Changes in Bile Acid Metabolism, Transport, and Signaling as Central Drivers for Metabolic Improvements After Bariatric Surgery

2019 ◽  
Vol 8 (2) ◽  
pp. 175-184 ◽  
Author(s):  
Matthew G. Browning ◽  
Bernardo M. Pessoa ◽  
Jad Khoraki ◽  
Guilherme M. Campos
Keyword(s):  
Bariatric Surgery ◽  
Bile Acid ◽  
Acid Metabolism ◽  
Bile Acid Metabolism

scholarly journals Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome

2016 ◽  
Vol 22 (39) ◽  
pp. 8698 ◽  
Author(s):  
Lukasz Kaska ◽  
Tomasz Sledzinski ◽  
Agnieszka Chomiczewska ◽  
Agnieszka Dettlaff-Pokora ◽  
Julian Swierczynski
Keyword(s):  
Bariatric Surgery ◽  
Bile Acid ◽  
Glucose Metabolism ◽  
Gut Microbiome

scholarly journals Significance of intestinal microbiota in implementing metabolic effects of bariatric surgery

2021 ◽  
Vol 10 (1) ◽  
Author(s):  
Marina A. Berkovskaya ◽  
Yulia P. Sych ◽  
Olesya Yu. Gurova ◽  
Valentin V. Fadeev
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Type 2 Diabetes Mellitus ◽  
Bile Acid ◽  
Intestinal Microbiota ◽  
Intestinal Microflora ◽  
Metabolic Effects ◽  
Bile Acid Metabolism

Bariatric surgery is among successful methods of obesity treatment, with effects going beyond weight reduction alone, but rather involving improved glucose tolerance, along with control or remission of the type 2 diabetes mellitus. The precise mechanisms causing metabolic effects of bariatric surgery are not fully elucidated, even though substantial evidence suggest that they include changes in the gut microbiota, bile acid homeostasis, and the close interactions of these factors. Intestinal microflora is directly involved in the energy metabolism of a host human. Obesity and type 2 diabetes mellitus are associated with certain changes in the species composition and diversity of intestinal microflora, which are considered important factors in the development and progression of these ailments. Bariatric surgery leads to significant and persistent changes in the composition of the intestinal microbiota, often bringing it closer to the characteristics of the microbiota of an average person with a normal weight. An important role in implementing the metabolic effects of bariatric surgery, primarily in the improvement of glucose metabolism, belongs to postoperative changes in homeostasis of bile acids. These changes imply close metabolism. Moreover, changes in the bile acid metabolism after bariatric surgery affect the microbiota of the host. Further study of these relationships would clarify the mechanisms underlying metabolic surgery, make it more predictable, targeted and controlled, as well as open new therapeutic targets in the treatment of obesity and associated conditions.

scholarly journals Bile acid, glucose, lipid profile, and liver enzyme changes in prediabetic patients 1 year after sleeve gastrectomy

2020 ◽  
Author(s):  
Tsz Kin Mak ◽  
Shifang Huang ◽  
Bingsheng Guan ◽  
Hoyin Au ◽  
Tsz Hong Chong ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Sleeve Gastrectomy ◽  
Bile Acid ◽  
Liver Enzyme ◽  
Total Bile Acid ◽  
First Year ◽  
Lipid Levels ◽  
Post Surgery ◽  
The Impact ◽  
Enzyme Changes

Abstract Background: Few articles have studied individuals with prediabetes after sleeve gastrectomy. Bile acid and lipid levels remain inconsistent in postbariatric patients. The purpose of this study was to explore bile acid, glucose, lipid, and liver enzyme changes in patients with different diabetes statuses who underwent sleeve gastrectomy. The impact of bariatric surgery and its potential benefits for prediabetic patients was also discussed.Methods: A total of 202 overweight and obese patients who underwent bariatric surgery in our hospital between January 2016 and October 2018 were retrospectively reviewed. Patients were divided into prediabetes (n=32), nondiabetes (n=144), and diabetes (n=26) groups and analysed. Glucose and lipid data were collected from medical records at baseline and at each follow-up visit.Result: Significant improvements in body weight, glucose and lipid levels, and liver enzymes (P≤0.05) in prediabetic patients were found throughout the first year postoperatively. Improvement in glycaemic control was first seen one month postoperatively, followed by persistent improvement in the next 12 months. Total bile acid (TBA) decreased, which was associated with ALT improvement in prediabetic patients 1-year post-surgery. There were no significant differences in HbA1c, glucose, or triglycerides (TGs) between prediabetic and T2DM patients or between prediabetic and nondiabetic patients at 12 months post-surgery.Conclusion: LSG is highly effective at interfering with glucose and lipid levels as well as total bile acid levels in prediabetic patients in the first year postoperatively. Thus, LSG is indeed an alternative for overweight and obese prediabetic patients.

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