NOP-Targeted Nonpeptide Ligands

2019 ◽  
pp. 37-67 ◽  
Author(s):  
Nurulain T. Zaveri ◽  
Michael E. Meyer
Keyword(s):  
Nonpeptide Ligands

Molecular drug targets for scabies: a medicinal chemistry perspective

2020 ◽  
Vol 12 (24) ◽  
pp. 2225-2238
Author(s):  
Wali Inam ◽  
Shelley Walton ◽  
Sheraz Khan ◽  
Wajahat Mahmood
Keyword(s):  
Protein Interactions ◽  
Drug Targets ◽  
Proteolytic Enzymes ◽  
Hydrolytic Enzymes ◽  
Sarcoptes Scabiei ◽  
Causative Organism ◽  
Protein Protein Interactions ◽  
Scabies Mite ◽  
Nonpeptide Ligands ◽  
Global Population

Sarcoptes scabiei is a causative organism for scabies that affects an estimated global population of 300 million and remains a disease of significant concern. Recently, a number of potential drug targets were identified for scabies, including hydrolytic enzymes, inactivated paralogues of hydrolytic enzymes, inhibitors of host proteolytic enzymes and other proteins of interest. These discoveries remain confined to academic laboratories and institutions, failing to attract interest from researchers in commercial drug development. Here, we summarize the latest developments in the scabies mite biology and the drug targets that were subsequently identified, and we propose several peptide and nonpeptide ligands targeting the hot spots for protein–protein interactions. We also identify gaps in the development of ligands as inhibitors or modulators of these macromolecules.

Nonpeptide Ligands That Target Peptide-Activated GPCRs In Inflammation

2005 ◽  
Vol 12 (25) ◽  
pp. 3027-3042 ◽  
Author(s):  
Jade Blakeney ◽  
David Fairlie
Keyword(s):  
Target Peptide ◽  
Nonpeptide Ligands

Structure-Based Design of a Novel Series of Nonpeptide Ligands That Bind to the pp60srcSH2 Domain

1997 ◽  
Vol 119 (51) ◽  
pp. 12471-12476 ◽  
Author(s):  
Elizabeth A. Lunney ◽  
Kimberly S. Para ◽  
J. Ronald Rubin ◽  
Christine Humblet ◽  
James H. Fergus ◽  
...  
Keyword(s):  
Nonpeptide Ligands

scholarly journals Three’s Company: Two or More Unrelated Receptors Pair with the Same Ligand

2005 ◽  
Vol 19 (5) ◽  
pp. 1097-1109 ◽  
Author(s):  
Izhar Ben-Shlomo ◽  
Aaron J. W. Hsueh
Keyword(s):  
Nuclear Receptors ◽  
Regulatory Networks ◽  
Phylogenetic Analyses ◽  
Structural Features ◽  
Membrane Receptors ◽  
Receptor Interaction ◽  
Unique Protein ◽  
Plasma Membrane Receptors ◽  
Nonpeptide Ligands ◽  
Cellular Components

Abstract Intercellular communication relies on signal transduction mediated by extracellular ligands and their receptors. Although the ligand-receptor interaction is usually a two-player event, there are selective examples of one polypeptide ligand interacting with more than one phylogenetically unrelated receptor. Likewise, a few receptors interact with more than one polypeptide ligand, and sometimes with more than one coreceptor, likely through an interlocking of unique protein domains. Phylogenetic analyses suggest that for certain triumvirates, the matching events could have taken place at different evolutionary times. In contrast to a few polypeptide ligands interacting with more than one receptor, we found that many small nonpeptide ligands have been paired with two or more plasma membrane receptors, nuclear receptors, or channels. The observation that many small ligands are paired with more than one receptor type highlights the utilitarian use of a limited number of cellular components during metazoan evolution. These conserved ligands are ubiquitous cell metabolites likely favored by natural selection to establish novel regulatory networks. They likely possess structural features useful for designing agonistic and antagonistic drugs to target diverse receptors.

Two distinct mechanisms determine the ability of nonpeptide ligands to activate the cholecystokinin-B/gastrin receptor

1998 ◽  
Vol 114 ◽  
pp. A1127
Author(s):  
M. Beinborn ◽  
M. Bläker ◽  
K. Schaffer ◽  
L.K. DeMeo ◽  
C. Chen ◽  
...  
Keyword(s):  
Gastrin Receptor ◽  
Nonpeptide Ligands
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