Clinical Pharmacology and Pharmacometrics to Better Understand Physiological Changes During Pregnancy and Neonatal Life

2019 ◽  
pp. 325-337
Author(s):  
Tamara van Donge ◽  
Katrina Evers ◽  
Gilbert Koch ◽  
John van den Anker ◽  
Marc Pfister
Keyword(s):  
Clinical Pharmacology ◽  
Physiological Changes ◽  
Neonatal Life

Clinical Pharmacology of Local Anaesthetics

Anaesthesia ◽  
2000 ◽  
Vol 55 (9) ◽  
pp. 938-938
Author(s):  
K. R. Milligan
Keyword(s):  
Clinical Pharmacology ◽  
Local Anaesthetics

Rapacuronium: clinical pharmacology

2001 ◽  
Vol 18 (Suppl. 23) ◽  
pp. 77-82 ◽  
Author(s):  
R. K. Mirakhur ◽  
K. C. McCourt
Keyword(s):  
Clinical Pharmacology

Inducing Unconscious Stress

2020 ◽  
Vol 34 (3) ◽  
pp. 192-201
Author(s):  
Melanie M. van der Ploeg ◽  
Jos F. Brosschot ◽  
Markus Quirin ◽  
Richard D. Lane ◽  
Bart Verkuil
Keyword(s):  
Repeated Measures ◽  
Activity Patterns ◽  
Physiological Changes ◽  
Implicit Measures ◽  
Prime Word ◽  
Student Sample ◽  
Priming Task ◽  
Subject Design ◽  
The Relationship ◽  
Stress And Health

Abstract. Stress-related stimuli may be presented outside of awareness and may ultimately influence health by causing repetitive increases in physiological parameters, such as blood pressure (BP). In this study, we aimed to corroborate previous studies that demonstrated BP effects of subliminally presented stress-related stimuli. This would add evidence to the hypothesis that unconscious manifestations of stress can affect somatic health. Additionally, we suggest that these findings may be extended by measuring affective changes relating to these physiological changes, using measures for self-reported and implicit positive and negative affectivity. Using a repeated measures between-subject design, we presented either the prime word “angry” ( n = 26) or “relax” ( n = 28) subliminally (17 ms) for 100 trials to a student sample and measured systolic and diastolic BP, heart rate (HR), and affect. The “angry” prime, compared to the “relax” prime, did not affect any of the outcome variables. During the priming task, a higher level of implicit negative affect (INA) was associated with a lower systolic BP and diastolic BP. No association was found with HR. Self-reported affect and implicit positive affect were not related to the cardiovascular (CV) activity. In sum, anger and relax primes elicited similar CV activity patterns, but implicit measures of affect may provide a new method to examine the relationship between (unconscious) stress and health.

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