Porcine Acellular Lung Matrix in Wound Healing and Hernia Repair

2018 ◽  
pp. 347-362
Author(s):  
Vishwanath Chegireddy ◽  
Koby D. Caplan ◽  
Joseph S. Fernandez-Moure
Keyword(s):  
Wound Healing ◽  
Hernia Repair ◽  
Lung Matrix

Wound healing process and mediators: Implications for modulations for hernia repair and mesh integration

2013 ◽  
Vol 102 (1) ◽  
pp. 295-302 ◽  
Author(s):  
Emmanuel E. Sadava ◽  
David M. Krpata ◽  
Yue Gao ◽  
Michael J. Rosen ◽  
Yuri W. Novitsky
Keyword(s):  
Wound Healing ◽  
Hernia Repair ◽  
Healing Process ◽  
Wound Healing Process

scholarly journals The Outcome of Darning method of inguinal hernia repair using polypropylene in Sir Ganga Ram Hospital, Lahore

2016 ◽  
Vol 12 (2) ◽  
Author(s):  
Ali Abid Naazar ◽  
Saleem Arshad ◽  
Abdul Waheed ◽  
Qureshi M S
Keyword(s):  
Wound Healing ◽  
Inguinal Hernia ◽  
Hernia Repair ◽  
General Anesthesia ◽  
Inguinal Hernia Repair ◽  
Urinary Retention ◽  
Recurrence Rate ◽  
Standard Procedure ◽  
Unilateral Inguinal Hernia ◽  
Polypropylene Material

Objectives: To valuate the darning method of inguinal hernia repair with polypropylene. Material and Methods: 300 patients of unilateral inguinal hernia were admitted. After thorough investigations, all patients were operated for hernia repair by standard procedure using No.1 polypropylene. Patients were operated under, spinal or general anesthesia. Patients were followed up at one week, six weeks and six months after operation for wound healing and complications. Results: Out of 300 patients, ranging in age from 20 to 70 years, 250 patients were given spinal anaesthesia, 45 patients (20%) were operated under local anesthesia. 196 patients were discharged from the hospital on the following day. 3 patients went into urinary retention and one patient had large haemotoma requiring exploration. Recurrence rate was 1% (n=3). Conclusion: Darning method of inguinal repair with polypropylene is a safe and cheaper method of hernia repair.

scholarly journals Porcine acellular lung matrix for wound healing and abdominal wall reconstruction: A pilot study

2016 ◽  
Vol 7 ◽  
pp. 204173141562601 ◽  
Author(s):  
Joseph S Fernandez-Moure ◽  
Jeffrey L Van Eps ◽  
Jessica R Rhudy ◽  
Fernando J Cabrera ◽  
Ghanashyam S Acharya ◽  
...  
Keyword(s):  
Wound Healing ◽  
Pilot Study ◽  
Abdominal Wall ◽  
Abdominal Wall Reconstruction ◽  
Lung Matrix

ultrastructural process of intestinal wound healing

1995 ◽  
Vol 53 ◽  
pp. 1024-1025
Author(s):  
Rick L. Vaughn ◽  
Shailendra K. Saxena ◽  
John G. Sharp
Keyword(s):  
Wound Healing ◽  
Epithelial Cells ◽  
Smooth Muscles ◽  
Microscopic Level ◽  
Light Microscopic Level ◽  
Ileal Mucosa ◽  
Wound Model ◽  
Serosal Surface ◽  
Complex Process ◽  
Orderly Fashion

We have developed an intestinal wound model that includes surgical construction of an ileo-cecal patch to study the complex process of intestinal wound healing. This allows approximation of ileal mucosa to the cecal serosa and facilitates regeneration of ileal mucosa onto the serosal surface of the cecum. The regeneration of ileal mucosa can then be evaluated at different times. The wound model also allows us to determine the rate of intestinal regeneration for a known size of intestinal wound and can be compared in different situations (e.g. with and without EGF and Peyer’s patches).At the light microscopic level it appeared that epithelial cells involved in regeneration of ileal mucosa originated from the enlarged crypts adjacent to the intestinal wound and migrated in an orderly fashion onto the serosal surface of the cecum. The migrating epithelial cells later formed crypts and villi by the process of invagination and evagination respectively. There were also signs of proliferation of smooth muscles underneath the migratory epithelial cells.

Healing gone wrong: convergence of hemostatic pathways and liver fibrosis?

2020 ◽  
Vol 134 (16) ◽  
pp. 2189-2201
Author(s):  
Jessica P.E. Davis ◽  
Stephen H. Caldwell
Keyword(s):  
Wound Healing ◽  
Liver Disease ◽  
Hepatic Fibrosis ◽  
Cell Activation ◽  
Stellate Cell ◽  
Factor Xa ◽  
Clinical Trial Data ◽  
Chronic Liver ◽  
Healing Response ◽  
Wound Healing Response

Abstract Fibrosis results from a disordered wound healing response within the liver with activated hepatic stellate cells laying down dense, collagen-rich extracellular matrix that eventually restricts liver hepatic synthetic function and causes increased sinusoidal resistance. The end result of progressive fibrosis, cirrhosis, is associated with significant morbidity and mortality as well as tremendous economic burden. Fibrosis can be conceptualized as an aberrant wound healing response analogous to a chronic ankle sprain that is driven by chronic liver injury commonly over decades. Two unique aspects of hepatic fibrosis – the chronic nature of insult required and the liver’s unique ability to regenerate – give an opportunity for pharmacologic intervention to stop or slow the pace of fibrosis in patients early in the course of their liver disease. Two potential biologic mechanisms link together hemostasis and fibrosis: focal parenchymal extinction and direct stellate cell activation by thrombin and Factor Xa. Available translational research further supports the role of thrombosis in fibrosis. In this review, we will summarize what is known about the convergence of hemostatic changes and hepatic fibrosis in chronic liver disease and present current preclinical and clinical data exploring the relationship between the two. We will also present clinical trial data that underscores the potential use of anticoagulant therapy as an antifibrotic factor in liver disease.

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