scholarly journals Efficient Processing of Multiple XML Twig Queries

2006 ◽  
pp. 1-11 ◽  
Author(s):  
Huanzhang Liu ◽  
Tok Wang Ling ◽  
Tian Yu ◽  
Ji Wu
Keyword(s):  
Efficient Processing ◽  
Twig Queries

Efficient processing of top-k twig queries over probabilistic XML data

2011 ◽  
Vol 16 (3) ◽  
pp. 299-323 ◽  
Author(s):  
Bo Ning ◽  
Chengfei Liu ◽  
Jeffrey Xu Yu
Keyword(s):  
Xml Data ◽  
Probabilistic Xml ◽  
Efficient Processing ◽  
Twig Queries

Efficient processing of distance–time kth-order skyline queries in bicriteria networks

2019 ◽  
Vol 13 (5) ◽  
pp. 796-802
Author(s):  
Jiping Zheng ◽  
Shunqing Jiang ◽  
Jialiang Chen ◽  
Wei Yu
Keyword(s):  
Skyline Queries ◽  
Efficient Processing

scholarly journals MAC5, an RNA-binding protein, protects pri-miRNAs from SERRATE-dependent exoribonuclease activities

2020 ◽  
Vol 117 (38) ◽  
pp. 23982-23990 ◽  
Author(s):  
Shengjun Li ◽  
Mu Li ◽  
Kan Liu ◽  
Huimin Zhang ◽  
Shuxin Zhang ◽  
...  
Keyword(s):  
Rna Binding ◽  
Rna Binding Protein ◽  
Dual Role ◽  
Mirna Biogenesis ◽  
Core Component ◽  
Stem Loop ◽  
Loop Region ◽  
Nuclear Rna ◽  
Efficient Processing ◽  
The Stability

MAC5 is a component of the conserved MOS4-associated complex. It plays critical roles in development and immunity. Here we report that MAC5 is required for microRNA (miRNA) biogenesis. MAC5 interacts with Serrate (SE), which is a core component of the microprocessor that processes primary miRNA transcripts (pri-miRNAs) into miRNAs and binds the stem-loop region of pri-miRNAs. MAC5 is essential for both the efficient processing and the stability of pri-miRNAs. Interestingly, the reduction of pri-miRNA levels inmac5is partially caused by XRN2/XRN3, the nuclear-localized 5′-to-3′ exoribonucleases, and depends on SE. These results reveal that MAC5 plays a dual role in promoting pri-miRNA processing and stability through its interaction with SE and/or pri-miRNAs. This study also uncovers that pri-miRNAs need to be protected from nuclear RNA decay machinery, which is connected to the microprocessor.

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