Upconverting Phosphor Labels for Bioanalytical Assays

2013 ◽  
pp. 155-204 ◽  
Author(s):  
Terhi Riuttamäki ◽  
Tero Soukka
Keyword(s):  
Bioanalytical Assays

SUMMARY OF CHROMATOGRAPHIC ANALYSIS METHODS OF ANTI DIABETIC GLIFLOZINS EMPAGLIFLOZIN, CANAGLIFLOZIN AND DAPAGLIFLOZIN

INDIAN DRUGS ◽  
2019 ◽  
Vol 56 (07) ◽  
pp. 80-83
Author(s):  
W. A Zaghary ◽  
S. Mowaka ◽  
M. S. Hendy ◽  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Biological Samples ◽  
Chromatographic Analysis ◽  
Dosage Forms ◽  
Drug Control ◽  
Bioanalytical Assays

Sodium glucose co-transporter-2 (SGLT-2) inhibitors are relatively new developed effective oral anti-diabetic agents used in treatment of type 2 Diabetes Mellitus. They present either alone or in combination with other ant diabetic agents such as linagliptin, Saxagliptin and metformin. Therefore, the necessity to explore and compare the existing analytical and bioanalytical assays used for determination of such drugs either single or in combination is crucial. Many methods were reported in the literature for the bio-analysis and analysis of three novel gliflozins with applying the method on different dosage forms and different chemical and biological samples. Furthermore, this review offered an overview of different methods used for determination of every drug alone in a tabulated comparative way. Moreover, the present review emphasized the most common stability indicating assays to be of interest to the analysts in the area of drug control.

Quantification of taxanes in biological matrices: a review of bioanalytical assays and recommendations for development of new assays

Bioanalysis ◽  
2014 ◽  
Vol 6 (7) ◽  
pp. 993-1010 ◽  
Author(s):  
JJMA Hendrikx ◽  
H Rosing ◽  
AH Schinkel ◽  
JHM Schellens ◽  
JH Beijnen
Keyword(s):  
Biological Matrices ◽  
Bioanalytical Assays

Stöber Synthesis of Monodispersed Luminescent Silica Nanoparticles for Bioanalytical Assays

Langmuir ◽  
2005 ◽  
Vol 21 (10) ◽  
pp. 4277-4280 ◽  
Author(s):  
Liane M. Rossi ◽  
Lifang Shi ◽  
Frank H. Quina ◽  
Zeev Rosenzweig
Keyword(s):  
Silica Nanoparticles ◽  
Bioanalytical Assays

Integrated air stream micromixer for performing bioanalytical assays on a plastic chip

Lab on a Chip ◽  
2014 ◽  
Vol 14 (19) ◽  
pp. 3750 ◽  
Author(s):  
Matthias Geissler ◽  
Kebin Li ◽  
Xuefeng Zhang ◽  
Liviu Clime ◽  
Gregg P. Robideau ◽  
...  
Keyword(s):  
Air Stream ◽  
Bioanalytical Assays

Bioanalytical Assays: RIA/EIA

2013 ◽  
pp. 869-886
Author(s):  
Heinz Jürgen Skrzipczyk ◽  
Patrick Verdier
Keyword(s):  
Bioanalytical Assays

scholarly journals DEVELOPMENT OF AN IMPROVED EPSTEIN-BARR VIRUS (EBV) NEUTRALIZING ANTIBODY ASSAY TO FACILITATE DEVELOPMENT OF A PROPHYLACTIC GP350-SUBUNIT EBV VACCINE

2020 ◽  
Vol 12 (1) ◽  
pp. e2020016
Author(s):  
Hui Liu ◽  
Lorraine Gemmell ◽  
Rui Lin ◽  
Fengrong Zuo ◽  
Henry H. Balfour ◽  
...  
Keyword(s):  
High Throughput ◽  
Neutralizing Antibody ◽  
Neutralization Assay ◽  
Epidemiologic Studies ◽  
Antibody Detection ◽  
Healthy Human ◽  
Barr Virus ◽  
Human Sera ◽  
Epstein Barr ◽  
Bioanalytical Assays

No licensed vaccine is available for prevention of EBV-associated diseases, and robust, sensitive, and high-throughput bioanalytical assays are needed to evaluate immunogenicity of gp350 subunit-based candidate EBV vaccines. Here we have developed and improved analytical tools for such a vaccine’s pre-clinical and clinical validation including a gp350-specific antibody detection assay and an EBV-GFP based neutralization assay for measuring EBV specific antibodies in human donors. The sensitivity of our previously published high-throughput EBV-GFP fluorescent focus (FFA)-based neutralization assay was further improved when guinea pig complement was supplemented using a panel of healthy human sera. Anti-gp350 antibody titers, which were evaluated using an anti-gp350 IgG ELISA assay optimized for capture and detection conditions, were moderately correlated to the FFA-based neutralization titers. Overall, these sensitive, and high-throughput bioanalytical assays are capable of characterizing the serologic response to natural EBV infection, with applications in evaluating EBV antibody status in epidemiologic studies and immunogenicity of candidate gp350-subunit EBV vaccines in clinical studies.

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