Inflammatory Biomarkers for Cardiovascular Risk Stratification in Familial Hypercholesterolemia

2020 ◽  
pp. 25-52
Author(s):  
Afsane Bahrami ◽  
Luca Liberale ◽  
Željko Reiner ◽  
Federico Carbone ◽  
Fabrizio Montecucco ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Risk Stratification ◽  
Familial Hypercholesterolemia ◽  
Inflammatory Biomarkers ◽  
Cardiovascular Risk Stratification

scholarly journals Novel Inflammatory Biomarkers as Additional Value to Traditional Risk-factors in Cardiovascular Risk Stratification

2020 ◽  
Vol 8 (B) ◽  
pp. 1092-1104
Author(s):  
Ana Vavlukis ◽  
Marija Vavlukis ◽  
Aleksandar Dimovski ◽  
Gordana Petrushevska ◽  
Aleksandar Eftimov ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Risk Stratification ◽  
Inflammatory Markers ◽  
Acute Phase Proteins ◽  
Female Gender ◽  
Inflammatory Biomarkers ◽  
Cvd Risk ◽  
Cardiovascular Risk Stratification ◽  
Traditional Risk Factors ◽  
Additional Value

BACKGROUND:: There is a growing interest in the possible role of inflammatory biomarkers, such as interleukins, chemokines, growth factors, and acute-phase proteins, in cardiovascular risk-stratification. AIM: The aim of the study was to determine a possible correlation between the subjects’ cardiovascular risk profile and various inflammatory markers and to assess the sole use of IL-6 in CVD risk prediction. MATERIALS AND METHODS: Seventy-five healthy subjects participated. EUROSCORE, lipid, glycemic, and inflammatory markers were analyzed. Сhi-square test, t-test, one-way ANOVA, Mann–Whitney, and Kruskal–Wallis tests were used. Significance was determined at <0.05. RESULTS: A multivariate analysis revealed 12 markers to be independently associated with CVD risk – LDL-C, TG, ApoB, HbA1c, hsCRP, IL-6, and IL-1A as markers of higher, and HDL-C, IL-4, Il-10, VEGF, and EGF as markers of lower CVD risk. IL-6 levels > 1 pg/ml were positively correlated with female gender, age > 55 years, EUROSCORE ≥ 3, risk age, SBP, hsCRP > 2 mg/L, and IL-2 (p = 0.025, p = 0.013, p = 0.025, p = 0.011, p = 0.026, p = 0.046, and p = 0.018). Except for total CVD risk and risk age, the same variables were identified to be independently associated with IL-6. CONCLUSION: Inflammatory biomarkers, especially hsCRP and IL-6, have a statistically significant, added predictive power in cardiovascular risk stratification.

Endothelial function and cardiovascular risk stratification in menopausal women

Climacteric ◽  
2010 ◽  
Vol 13 (1) ◽  
pp. 45-54 ◽  
Author(s):  
S. L. Mulvagh ◽  
T. Behrenbeck ◽  
B. A. Lahr ◽  
K. R. Bailey ◽  
T. G. Zais ◽  
...  
Keyword(s):  
Cardiovascular Risk ◽  
Risk Stratification ◽  
Endothelial Function ◽  
Cardiovascular Risk Stratification ◽  
Menopausal Women
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