Regulation of Renin Release by Local and Systemic Factors

2009 ◽  
pp. 1-44 ◽  
Author(s):  
F. Schweda ◽  
A. Kurtz
Keyword(s):  
Renin Release ◽  
Systemic Factors

The role of personality in shaping pandemic response: Systemic sociopolitical factors drive country differences

2020 ◽  
Author(s):  
Meghan Siritzky ◽  
David M Condon ◽  
Sara J Weston
Keyword(s):  
Individual Differences ◽  
Big Five ◽  
Public Health Research ◽  
Cross Cultural ◽  
Economic Factors ◽  
State Fragility ◽  
Systemic Factors ◽  
Pandemic Response ◽  
The Relationship

The current study utilizes the current COVID-19 pandemic to highlight the importance of accounting for the influence of external political and economic factors in personality public-health research. We investigated the extent to which systemic factors modify the relationship between personality and pandemic response. Results shed doubt on the cross-cultural generalizability of common big-five factor models. Individual differences only predicted government compliance in autocratic countries and in countries with income inequality. Personality was only predictive of mental health outcomes under conditions of state fragility and autocracy. Finally, there was little evidence that the big five traits were associated with preventive behaviors. Our ability to use individual differences to understand policy-relevant outcomes changes based on environmental factors and must be assessed on a trait-by-trait basis, thus supporting the inclusion of systemic political and economic factors in individual differences models.

Adrenomedullin Stimulates Renin Release and Renin mRNA in Mouse Juxtaglomerular Granular Cells

Hypertension ◽  
1997 ◽  
Vol 29 (5) ◽  
pp. 1148-1155 ◽  
Author(s):  
Boye L. Jensen ◽  
Bernhard K. Krämer ◽  
Armin Kurtz
Keyword(s):  
Renin Release ◽  
Granular Cells ◽  
Renin Mrna

scholarly journals Targeting obesity-related dysfunction in hormonally driven cancers

2021 ◽  
Author(s):  
Maria M. Rubinstein ◽  
Kristy A. Brown ◽  
Neil M. Iyengar
Keyword(s):  
Cell Signalling ◽  
Treatment Resistance ◽  
Tumour Microenvironment ◽  
Subsequent Increase ◽  
Treatment And Prevention ◽  
Cancer Pathogenesis ◽  
Diet And Exercise ◽  
Systemic Factors ◽  
Tumour Vascularity ◽  
Obesity And Cancer

AbstractObesity is a risk factor for at least 13 different types of cancer, many of which are hormonally driven, and is associated with increased cancer incidence and morbidity. Adult obesity rates are steadily increasing and a subsequent increase in cancer burden is anticipated. Obesity-related dysfunction can contribute to cancer pathogenesis and treatment resistance through various mechanisms, including those mediated by insulin, leptin, adipokine, and aromatase signalling pathways, particularly in women. Furthermore, adiposity-related changes can influence tumour vascularity and inflammation in the tumour microenvironment, which can support tumour development and growth. Trials investigating non-pharmacological approaches to target the mechanisms driving obesity-mediated cancer pathogenesis are emerging and are necessary to better appreciate the interplay between malignancy, adiposity, diet and exercise. Diet, exercise and bariatric surgery are potential strategies to reverse the cancer-promoting effects of obesity; trials of these interventions should be conducted in a scientifically rigorous manner with dose escalation and appropriate selection of tumour phenotypes and have cancer-related clinical and mechanistic endpoints. We are only beginning to understand the mechanisms by which obesity effects cell signalling and systemic factors that contribute to oncogenesis. As the rates of obesity and cancer increase, we must promote the development of non-pharmacological lifestyle trials for the treatment and prevention of malignancy.

scholarly journals Microglia in Neurodegenerative Events—An Initiator or a Significant Other?

2021 ◽  
Vol 22 (11) ◽  
pp. 5818
Author(s):  
Gaylia Jean Harry
Keyword(s):  
Neurovascular Unit ◽  
Cell Types ◽  
In Vitro Assays ◽  
Significant Other ◽  
Neurodegenerative Process ◽  
Target Sites ◽  
Systemic Factors ◽  
Injury And Repair ◽  
The Brain

A change in microglia structure, signaling, or function is commonly associated with neurodegeneration. This is evident in the patient population, animal models, and targeted in vitro assays. While there is a clear association, it is not evident that microglia serve as an initiator of neurodegeneration. Rather, the dynamics imply a close interaction between the various cell types and structures in the brain that orchestrate the injury and repair responses. Communication between microglia and neurons contributes to the physiological phenotype of microglia maintaining cells in a surveillance state and allows the cells to respond to events occurring in their environment. Interactions between microglia and astrocytes is not as well characterized, nor are interactions with other members of the neurovascular unit; however, given the influence of systemic factors on neuroinflammation and disease progression, such interactions likely represent significant contributes to any neurodegenerative process. In addition, they offer multiple target sites/processes by which environmental exposures could contribute to neurodegenerative disease. Thus, microglia at least play a role as a significant other with an equal partnership; however, claiming a role as an initiator of neurodegeneration remains somewhat controversial.

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