Integration of Systems Biology with Bioprocess Engineering: l-Threonine Production by Systems Metabolic Engineering of Escherichia Coli

2010 ◽  
pp. 1-19 ◽  
Author(s):  
Sang Yup Lee ◽  
Jin Hwan Park
Keyword(s):  
Escherichia Coli ◽  
Metabolic Engineering ◽  
Systems Biology ◽  
Bioprocess Engineering ◽  
Systems Metabolic Engineering ◽  
Threonine Production

scholarly journals Systems metabolic engineering of Escherichia coli for L ‐threonine production

2007 ◽  
Vol 3 (1) ◽  
pp. 149 ◽  
Author(s):  
Kwang Ho Lee ◽  
Jin Hwan Park ◽  
Tae Yong Kim ◽  
Hyun Uk Kim ◽  
Sang Yup Lee
Keyword(s):  
Escherichia Coli ◽  
Metabolic Engineering ◽  
Systems Metabolic Engineering ◽  
Threonine Production

Escherichia coli as a platform microbial host for systems metabolic engineering

2021 ◽  
Author(s):  
Dongsoo Yang ◽  
Cindy Pricilia Surya Prabowo ◽  
Hyunmin Eun ◽  
Seon Young Park ◽  
In Jin Cho ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Natural Products ◽  
Metabolic Engineering ◽  
Food Ingredients ◽  
E Coli ◽  
Renewable Biomass ◽  
Microbial Cell Factories ◽  
Cell Factories ◽  
Systems Metabolic Engineering ◽  
Microbial Host

Abstract Bio-based production of industrially important chemicals and materials from non-edible and renewable biomass has become increasingly important to resolve the urgent worldwide issues including climate change. Also, bio-based production, instead of chemical synthesis, of food ingredients and natural products has gained ever increasing interest for health benefits. Systems metabolic engineering allows more efficient development of microbial cell factories capable of sustainable, green, and human-friendly production of diverse chemicals and materials. Escherichia coli is unarguably the most widely employed host strain for the bio-based production of chemicals and materials. In the present paper, we review the tools and strategies employed for systems metabolic engineering of E. coli. Next, representative examples and strategies for the production of chemicals including biofuels, bulk and specialty chemicals, and natural products are discussed, followed by discussion on materials including polyhydroxyalkanoates (PHAs), proteins, and nanomaterials. Lastly, future perspectives and challenges remaining for systems metabolic engineering of E. coli are discussed.

scholarly journals Metabolic engineering of a reduced-genome strain of Escherichia coli for L-threonine production

2009 ◽  
Vol 8 (1) ◽  
pp. 2 ◽  
Author(s):  
Jun Lee ◽  
Bong Sung ◽  
Mi Kim ◽  
Frederick R Blattner ◽  
Byoung Yoon ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Metabolic Engineering ◽  
Reduced Genome ◽  
Threonine Production

Systems metabolic engineering of Escherichia coli for production of the antitumor drugs violacein and deoxyviolacein

2013 ◽  
Vol 20 ◽  
pp. 29-41 ◽  
Author(s):  
André L. Rodrigues ◽  
Nathalie Trachtmann ◽  
Judith Becker ◽  
Ananta F. Lohanatha ◽  
Jana Blotenberg ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Metabolic Engineering ◽  
Antitumor Drugs ◽  
Systems Metabolic Engineering

scholarly journals Systems Metabolic Engineering of Escherichia coli Improves Coconversion of Lignocellulose‐Derived Sugars

2019 ◽  
Vol 14 (9) ◽  
pp. 1800441 ◽  
Author(s):  
Joonhoon Kim ◽  
Mary Tremaine ◽  
Jeffrey A. Grass ◽  
Hugh M. Purdy ◽  
Robert Landick ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Metabolic Engineering ◽  
Systems Metabolic Engineering
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