Microbial Transformation of Nitriles to High-Value Acids or Amides

2009 ◽  
pp. 33-77 ◽  
Author(s):  
Jing Chen ◽  
Ren-Chao Zheng ◽  
Yu-Guo Zheng ◽  
Yin-Chu Shen
Keyword(s):  
Microbial Transformation

TLC/HPTLC and HPLC methods for monitoring microbial transformation processes

2004 ◽  
Vol 17 (2) ◽  
pp. 132-136 ◽  
Author(s):  
Balázs Erdélyi ◽  
Antal Szabó ◽  
László Birincsik ◽  
Gábor Seres ◽  
János Salát ◽  
...  
Keyword(s):  
Microbial Transformation ◽  
Transformation Processes

Microbial Bioconversion: A Regio-specific Method for Novel Drug Design and Toxicological Study of Metabolites

2019 ◽  
Vol 20 (14) ◽  
pp. 1156-1162
Author(s):  
Maria Yousuf ◽  
Waqas Jamil ◽  
Khayala Mammadova
Keyword(s):  
Microbial Transformation ◽  
Specific Method ◽  
Reaction Conditions ◽  
Small Organic Molecules ◽  
Toxicological Studies ◽  
Drug Designing ◽  
Transformation Methods ◽  
Novel Drug

The methods of chemical structural alteration of small organic molecules by using microbes (fungi, bacteria, yeast, etc.) are gaining tremendous attention to obtain structurally novel and therapeutically potential leads. The regiospecific mild environmental friendly reaction conditions with the ability of novel chemical structural modification in compounds categorize this technique; a distinguished and unique way to obtain medicinally important drugs and their in vivo mimic metabolites with costeffective and timely manner. This review article shortly addresses the immense pharmaceutical importance of microbial transformation methods in drug designing and development as well as the role of CYP450 enzymes in fungi to obtain in vivo drug metabolites for toxicological studies.

scholarly journals A Novel Microbial Zearalenone Transformation through Phosphorylation

Toxins ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 294
Author(s):  
Yan Zhu ◽  
Pascal Drouin ◽  
Dion Lepp ◽  
Xiu-Zhen Li ◽  
Honghui Zhu ◽  
...  
Keyword(s):  
Microbial Transformation ◽  
Acid Tolerance ◽  
Transformation Product ◽  
The United States ◽  
Corn Silage ◽  
Rrna Gene ◽  
Bacillus Spp ◽  
High Concentrations ◽  
The 16S Rrna Gene ◽  
Bacillus Strains

Zearalenone (ZEA) is a mycotoxin widely occurring in many agricultural commodities. In this study, a purified bacterial isolate, Bacillus sp. S62-W, obtained from one of 104 corn silage samples from various silos located in the United States, exhibited activity to transform the mycotoxin ZEA. A novel microbial transformation product, ZEA-14-phosphate, was detected, purified, and identified by HPLC, LC-MS, and NMR analyses. The isolate has been identified as belonging to the genus Bacillus according to phylogenetic analysis of the 16S rRNA gene and whole genome alignments. The isolate showed high efficacy in transforming ZEA to ZEA-14-phosphate (100% transformation within 24 h) and possessed advantages of acid tolerance (work at pH = 4.0), working under a broad range of temperatures (22–42 °C), and a capability of transforming ZEA at high concentrations (up to 200 µg/mL). In addition, 23 Bacillus strains of various species were tested for their ZEA phosphorylation activity. Thirteen of the Bacillus strains showed phosphorylation functionality at an efficacy of between 20.3% and 99.4% after 24 h incubation, suggesting the metabolism pathway is widely conserved in Bacillus spp. This study established a new transformation system for potential application of controlling ZEA although the metabolism and toxicity of ZEA-14-phosphate requires further investigation.

Interfacial biocatalysis in bacteria-stabilized Pickering emulsions for microbial transformation of hydrophobic chemicals

2021 ◽  
Author(s):  
Haisheng Xie ◽  
Wenyu Zhao ◽  
Daniel Chikere Ali ◽  
Xuehong Zhang ◽  
Zhilong Wang
Keyword(s):  
Microbial Transformation ◽  
Pickering Emulsion ◽  
Pickering Emulsions

The Pickering emulsion interface is an exceptional habitat for bacteria to grow by simultaneously utilizing hydrophobic and hydrophilic chemicals.

Microbial Transformation of L-696, 474, a Novel Cytochalasin as an Inhibitor of HIV-1 Protease

1993 ◽  
Vol 56 (5) ◽  
pp. 755-761 ◽  
Author(s):  
Tom S. Chen ◽  
George A. Doss ◽  
Annjia Hsu ◽  
Amy Hsu ◽  
Russell B. Lingham ◽  
...  
Keyword(s):  
Microbial Transformation ◽  
Hiv 1

Microbial transformation of synthetic estrogen 17α-ethinylestradiol

2009 ◽  
Vol 157 (12) ◽  
pp. 3325-3335 ◽  
Author(s):  
Tomáš Cajthaml ◽  
Zdena Křesinová ◽  
Kateřina Svobodová ◽  
Karel Sigler ◽  
Tomáš Řezanka
Keyword(s):  
Microbial Transformation ◽  
Synthetic Estrogen

scholarly journals 3.ALPHA.-Hydroxy-ML-236B(3.ALPHA.-hydroxycompactin), microbial transformation product of ML-236B (compactin)

1983 ◽  
Vol 36 (5) ◽  
pp. 608-610 ◽  
Author(s):  
NOBUFUSAS ERIZAWA ◽  
KEIKO NAKAGAWA ◽  
YOSHIO TSUJITA ◽  
AKIRA TERAHARA ◽  
HARUMITSUK UWANO
Keyword(s):  
Microbial Transformation ◽  
Transformation Product
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