Hydroxylated polychlorinated Biphenyls (PCBs) and Organochlorine Pesticides as Potential Endocrine Disruptors

2006 ◽  
pp. 155-167 ◽  
Author(s):  
Stephen Safe
Keyword(s):  
Polychlorinated Biphenyls ◽  
Organochlorine Pesticides ◽  
Endocrine Disruptors ◽  
Hydroxylated Polychlorinated Biphenyls

scholarly journals Serum levels of organochlorine pesticides and polychlorinated biphenyls among inhabitants of Greater Metropolitan Rio de Janeiro, Brazil

2002 ◽  
Vol 18 (2) ◽  
pp. 519-524 ◽  
Author(s):  
Isabella Fernandes Delgado ◽  
Heloisa H.C. Barretto ◽  
Teresa A. Kussumi ◽  
Irene Baptista Alleluia ◽  
Cenira de A. Baggio ◽  
...  
Keyword(s):  
Detection Limit ◽  
Polychlorinated Biphenyls ◽  
Organochlorine Pesticides ◽  
Rio De Janeiro ◽  
Serum Lipids ◽  
Serum Levels ◽  
Electron Capture Detection ◽  
Persistent Organochlorine ◽  
Alpha Beta ◽  
Janeiro City

Levels of persistent organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) were determined in the blood serum of people living and working in the urban area of greater Rio de Janeiro city. Blood samples from 33 volunteers (16 males, 17 females, 19-63 years old) were taken in January 1999. OCP residues (op'DDT, pp'DDT, pp'DDD, pp'DDE, Aldrin, Dieldrin, Endrin, Heptachlor, Heptachlor-epoxide, alpha-, beta- and gamma-Hexachlorocyclo-hexane, Hexachlorobenzene) and PCBs (congeners: 28, 52, 101, 138, 153, 180) were extracted with n-hexane and analyzed by gas chromatography with electron capture detection. Except for pp'DDE (detection limit = 1.4µg/L) no other OCP residue was found in the samples. No PCB congener (detection limit = 2.0µg/L) was detected either. pp'DDE was found in 17 out of 33 samples in concentrations that ranged from 1.4 to 8.4 µg/L of serum or, on a fat basis, from 0.200 to 3.452 µg/g of serum lipids. Percentage of positive samples (%) and levels of pp'DDE (range of positive samples) increased from the youngest to the oldest group (<=29 yrs: 10%, 0.278µg/g; 30-39 yrs: 60%, 0.200-0.765µg/g; > or = 40 yrs: 77%, 0.257-3.452µg/g).

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