4.10.2.3 Interactions of peptides containing basic amino acids with nucleic acids

2005 ◽  
pp. 271-273
Author(s):  
D. Porschke
Keyword(s):  
Amino Acids ◽  
Nucleic Acids ◽  
Basic Amino Acids

Partial intercalation with nucleic acids of peptides containing aromatic and basic amino acids

1999 ◽  
Vol 5 (5) ◽  
pp. 313-322 ◽  
Author(s):  
Cynthia Robledo-Luiggi ◽  
Marisol Vera ◽  
Liliana Cobo ◽  
Ervia Jaime ◽  
Carmen Mart�nez ◽  
...  
Keyword(s):  
Amino Acids ◽  
Nucleic Acids ◽  
Basic Amino Acids

Does the polyamine carrier system absorb basic amino acids?

2001 ◽  
Vol 120 (5) ◽  
pp. A142-A142
Author(s):  
J GASKEY ◽  
E SEIDEL
Keyword(s):  
Amino Acids ◽  
Carrier System ◽  
Basic Amino Acids

Atypical amino acids inhibit histidine, valine, or lysine transport into rat brain

1983 ◽  
Vol 245 (4) ◽  
pp. R556-R563 ◽  
Author(s):  
J. K. Tews ◽  
A. E. Harper
Keyword(s):  
Amino Acids ◽  
Rat Brain ◽  
Blood Brain Barrier ◽  
Brain Slices ◽  
Aromatic Amino Acids ◽  
Brain Barrier ◽  
Basic Amino Acids ◽  
Large Neutral Amino Acids ◽  
Neutral Amino Acids ◽  
Single Meal

Transport of histidine, valine, or lysine into rat brain slices and across the blood-brain barrier (BBB) was determined in the presence of atypical nonprotein amino acids. Competitors of histidine and valine transport in slices were large neutral amino acids including norleucine, norvaline, alpha-aminooctanoate, beta-methylphenylalanine, and alpha-aminophenylacetate. Less effective were aromatic amino acids with ring substituents; ineffective were basic amino acids and omega-amino isomers of norleucine and aminooctanoate. Lysine transport was moderately depressed by homoarginine or ornithine plus arginine; large neutral amino acids were also similarly inhibitory. Histidine or valine transport across the BBB was also strongly inhibited by large neutral amino acids that were the most effective competitors in the slices (norvaline, norleucine, alpha-aminooctanoate, and alpha-aminophenylacetate); homoarginine and 8-aminooctanoate were ineffective. Homoarginine, ornithine, and arginine almost completely blocked lysine transport, but the large neutral amino acids were barely inhibitory. When rats were fed a single meal containing individual atypical large neutral amino acids or homoarginine, brain pools of certain large neutral amino acids or of arginine and lysine, respectively, were depleted.

scholarly journals THE BASIC AMINO ACIDS OF WOOL

1930 ◽  
Vol 86 (1) ◽  
pp. 107-111
Author(s):  
Hubert Bradford Vickery ◽  
Richard J. Block
Keyword(s):  
Amino Acids ◽  
Basic Amino Acids

scholarly journals THE BASIC AMINO ACIDS OF SERUM PROTEINS

1934 ◽  
Vol 104 (2) ◽  
pp. 347-350
Author(s):  
Richard J. Block ◽  
Daniel C. Darrow ◽  
M. Katherine Cary
Keyword(s):  
Amino Acids ◽  
Serum Proteins ◽  
Basic Amino Acids

scholarly journals Effects of Basic Amino Acids and Their Derivatives on SARS-CoV-2 and Influenza-A Virus Infection

Viruses ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1301
Author(s):  
Ivonne Melano ◽  
Li-Lan Kuo ◽  
Yan-Chung Lo ◽  
Po-Wei Sung ◽  
Ni Tien ◽  
...  
Keyword(s):  
Amino Acids ◽  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Enveloped Viruses ◽  
Virus Attachment ◽  
Basic Amino Acids ◽  
Ester Derivative ◽  
Endosomal Acidification

Amino acids have been implicated with virus infection and replication. Here, we demonstrate the effects of two basic amino acids, arginine and lysine, and their ester derivatives on infection of two enveloped viruses, SARS-CoV-2, and influenza A virus. We found that lysine and its ester derivative can efficiently block infection of both viruses in vitro. Furthermore, the arginine ester derivative caused a significant boost in virus infection. Studies on their mechanism of action revealed that the compounds potentially disturb virus uncoating rather than virus attachment and endosomal acidification. Our findings suggest that lysine supplementation and the reduction of arginine-rich food intake can be considered as prophylactic and therapeutic regimens against these viruses while also providing a paradigm for the development of broad-spectrum antivirals.

scholarly journals THE BASIC AMINO ACIDS OF LIVETIN

1932 ◽  
Vol 98 (2) ◽  
pp. 783-788
Author(s):  
T.H. Jukes ◽  
H.D. Kay
Keyword(s):  
Amino Acids ◽  
Basic Amino Acids
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