scholarly journals Mapping of the Bovine Immunodeficiency Virus Packaging Signal and RRE and Incorporation into a Minimal Gene Transfer Vector

Virology ◽  
2002 ◽  
Vol 304 (1) ◽  
pp. 10-23 ◽  
Author(s):  
Rene P. Molina ◽  
Meghan Matukonis ◽  
Brian Paszkiet ◽  
Jingli Zhang ◽  
Michael Kaleko ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Bovine Immunodeficiency Virus ◽  
Packaging Signal ◽  
Transfer Vector ◽  
Gene Transfer Vector ◽  
Immunodeficiency Virus ◽  
Virus Packaging

scholarly journals Feline Immunodeficiency Virus as a Gene Transfer Vector in the Rat Nucleus Tractus Solitarii

2009 ◽  
Vol 30 (3) ◽  
pp. 339-346 ◽  
Author(s):  
L. H. Lin ◽  
J. E. Langasek ◽  
L. S. Talman ◽  
O. M. Taktakishvili ◽  
W. T. Talman
Keyword(s):  
Gene Transfer ◽  
Feline Immunodeficiency Virus ◽  
Nucleus Tractus Solitarii ◽  
Transfer Vector ◽  
Gene Transfer Vector ◽  
Immunodeficiency Virus

The piggyBac transposon is an integrating non-viral gene transfer vector that enhances the efficiency of GDEPT

2009 ◽  
Vol 33 (4) ◽  
pp. 509-515 ◽  
Author(s):  
Yu Kang ◽  
Xiao-Yan Zhang ◽  
Wei Jiang ◽  
Chao-Qun Wu ◽  
Chun-Mei Chen ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Viral Gene ◽  
Piggybac Transposon ◽  
Transfer Vector ◽  
Gene Transfer Vector ◽  
Viral Gene Transfer

Transgene Expression in the Guinea Pig Cochlea Mediated by a Lentivirus-Derived Gene Transfer Vector

1999 ◽  
Vol 10 (11) ◽  
pp. 1867-1873 ◽  
Author(s):  
Jay J. Han ◽  
Anand N. Mhatre ◽  
Michael Wareing ◽  
Robert Pettis ◽  
Wei-Qiang Gao ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Guinea Pig ◽  
Transgene Expression ◽  
Transfer Vector ◽  
Guinea Pig Cochlea ◽  
Gene Transfer Vector

scholarly journals Construction and Molecular Analysis of Gene Transfer Systems Derived from Bovine Immunodeficiency Virus

2001 ◽  
Vol 75 (7) ◽  
pp. 3371-3382 ◽  
Author(s):  
Robert Berkowitz ◽  
Heini Ilves ◽  
Wei Yu Lin ◽  
Karl Eckert ◽  
Andrea Coward ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Target Cell ◽  
Expression System ◽  
Cell Types ◽  
Human Cells ◽  
Bovine Immunodeficiency Virus ◽  
Transduction Efficiency ◽  
Hematopoietic Stem ◽  
Immunodeficiency Virus ◽  
Immortalized Cell

ABSTRACT Because lentiviruses are able to infect nondividing cells, these viruses might be utilized in gene therapy applications where the target cell does not divide. However, it has been suggested that the introduction of primate lentivirus sequences, particularly those of human immunodeficiency virus, into human cells may pose a health risk for the patient. To avoid this concern, we have constructed gene transfer systems based on a nonprimate lentivirus, bovine immunodeficiency virus. A panel of vectors and packaging constructs was generated and analyzed in a transient expression system for virion production and maturation, vector expression and encapsidation, and envelope protein pseudotyping. Virion preparations were also analyzed for transduction efficiency in a panel of human and nonhuman primary cells and immortalized cell lines. The virion preparations transduced most of the target cell types, with efficiencies up to 90% and with titers of unconcentrated virus up to 5 × 105infectious doses/ml. In addition, infection of nondividing human cells, including unstimulated hematopoietic stem cells and irradiated endothelial cells, was observed.

scholarly journals Development of adenovirus serotype 35 as a gene transfer vector

Virology ◽  
2003 ◽  
Vol 311 (2) ◽  
pp. 384-393 ◽  
Author(s):  
P Seshidhar Reddy ◽  
Shanthi Ganesh ◽  
M.Paullin Limbach ◽  
Terrence Brann ◽  
Anne Pinkstaff ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Adenovirus Serotype ◽  
Transfer Vector ◽  
Gene Transfer Vector
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