scholarly journals Murine Coronavirus-Induced Apoptosis in 17Cl-1 Cells Involves a Mitochondria-Mediated Pathway and Its Downstream Caspase-8 Activation and Bid Cleavage

Virology ◽  
2002 ◽  
Vol 302 (2) ◽  
pp. 321-332 ◽  
Author(s):  
Chun-Jen Chen ◽  
Shinji Makino
Keyword(s):  
Caspase 8 ◽  
Induced Apoptosis ◽  
Murine Coronavirus

Lamotrigine Attenuates Proteasome Inhibition-Induced Apoptosis by Suppressing the Activation of the Mitochondrial Pathway and the Caspase-8- and Bid-Dependent Pathways

2016 ◽  
Vol 41 (10) ◽  
pp. 2503-2516 ◽  
Author(s):  
Yoon Jeong Nam ◽  
Arum Kim ◽  
Min Sung Lee ◽  
Yong Kyoo Shin ◽  
Dong Suep Sohn ◽  
...  
Keyword(s):  
Proteasome Inhibition ◽  
Mitochondrial Pathway ◽  
Caspase 8 ◽  
Induced Apoptosis

scholarly journals Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

Oncogene ◽  
2001 ◽  
Vol 20 (41) ◽  
pp. 5865-5877 ◽  
Author(s):  
Simone Fulda ◽  
Martin U Küfer ◽  
Eric Meyer ◽  
Frans van Valen ◽  
Barbara Dockhorn-Dworniczak ◽  
...  
Keyword(s):  
Gene Transfer ◽  
Death Receptor ◽  
Caspase 8 ◽  
Drug Induced ◽  
Or Gene ◽  
Induced Apoptosis

scholarly journals Cleavage by Caspase 8 and Mitochondrial Membrane Association Activate the BH3-only Protein Bid during TRAIL-induced Apoptosis

2016 ◽  
Vol 291 (22) ◽  
pp. 11843-11851 ◽  
Author(s):  
Kai Huang ◽  
Jingjing Zhang ◽  
Katelyn L. O'Neill ◽  
Channabasavaiah B. Gurumurthy ◽  
Rolen M. Quadros ◽  
...  
Keyword(s):  
Mitochondrial Membrane ◽  
Caspase 8 ◽  
Membrane Association ◽  
Induced Apoptosis

scholarly journals Important Role of β1-Integrin in Fucoidan-Induced Apoptosis via Caspase-8 Activation

2012 ◽  
Vol 76 (6) ◽  
pp. 1163-1168 ◽  
Author(s):  
Yumi YAMASAKI ◽  
Masao YAMASAKI ◽  
Hirofumi TACHIBANA ◽  
Koji YAMADA
Keyword(s):  
Caspase 8 ◽  
Induced Apoptosis

scholarly journals Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marie-Anaïs Locquet ◽  
Gabriel Ichim ◽  
Joseph Bisaccia ◽  
Aurelie Dutour ◽  
Serge Lebecque ◽  
...  
Keyword(s):  
Cell Death ◽  
Cancer Cells ◽  
Neuroblastoma Cell ◽  
Death Receptor ◽  
Neuroblastoma Cell Line ◽  
Caspase 8 ◽  
Caspase Activation ◽  
Extrinsic Pathway ◽  
Lysosomal Membrane Permeabilization ◽  
Induced Apoptosis

AbstractIn cancer cells only, TLR3 acquires death receptor properties by efficiently triggering the extrinsic pathway of apoptosis with Caspase-8 as apical protease. Here, we demonstrate that in the absence of Caspase-8, activation of TLR3 can trigger a form of programmed cell death, which is distinct from classical apoptosis. When TLR3 was activated in the Caspase-8 negative neuroblastoma cell line SH-SY5Y, cell death was accompanied by lysosomal permeabilization. Despite caspases being activated, lysosomal permeabilization as well as cell death were not affected by blocking caspase-activity, positioning lysosomal membrane permeabilization (LMP) upstream of caspase activation. Taken together, our data suggest that LMP with its deadly consequences represents a “default” death mechanism in cancer cells, when Caspase-8 is absent and apoptosis cannot be induced.

scholarly journals Caspase-8 acts as a key upstream executor of mitochondria during justicidin A-induced apoptosis in human hepatoma cells

FEBS Letters ◽  
2006 ◽  
Vol 580 (13) ◽  
pp. 3185-3191 ◽  
Author(s):  
Chun-Li Su ◽  
Lynn L.H. Huang ◽  
Li-Min Huang ◽  
Jenq-Chang Lee ◽  
Chun-Nan Lin ◽  
...  
Keyword(s):  
Hepatoma Cells ◽  
Caspase 8 ◽  
Human Hepatoma ◽  
Human Hepatoma Cells ◽  
Induced Apoptosis

Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells

2009 ◽  
Vol 459 (2) ◽  
pp. 47-51 ◽  
Author(s):  
Ali. M. Sharifi ◽  
Habib Eslami ◽  
Bagher Larijani ◽  
Jamshid Davoodi
Keyword(s):  
Pc12 Cells ◽  
High Glucose ◽  
Caspase 8 ◽  
Induced Apoptosis
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