scholarly journals The Epstein–Barr Virus Latent Membrane Protein 1 Induces Interleukin-10 in Burkitt's Lymphoma Cells but Not in Hodgkin's Cells Involving the p38/SAPK2 Pathway

Virology ◽  
2001 ◽  
Vol 280 (2) ◽  
pp. 183-198 ◽  
Author(s):  
Martina Vockerodt ◽  
Birgit Haier ◽  
Peter Buttgereit ◽  
Hans Tesch ◽  
Dieter Kube
Keyword(s):  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Burkitt’S Lymphoma ◽  
Interleukin 10 ◽  
Latent Membrane Protein ◽  
Latent Membrane Protein 1 ◽  
Lymphoma Cells ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Latent Membrane Protein

scholarly journals Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Xintao Jia ◽  
Qiuyu He ◽  
Mei Zeng ◽  
Yuhua Chen ◽  
Yan Liu
Keyword(s):  
Membrane Protein ◽  
Signaling Pathway ◽  
Epstein Barr Virus ◽  
Latent Membrane Protein ◽  
Latent Membrane Protein 1 ◽  
Lymphoma Cells ◽  
Nrf2 Pathway ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Latent Membrane Protein

Epstein-Barr virus-latent membrane protein 1 (EBV-LMP1) was associated with lymphoma, but its specific mechanism is still controversial. The study is aimed at studying the regulation of lymphoma resistance by EBV-LMP1 through the MEK1/2/Nrf-2 signaling pathway. First, LMP1 was knocked down in EBV-positive SNK-6 cells and overexpressed in EBV-negative KHYG-1 cells. First, we found that overexpression of LMP1 significantly promoted the resistance of KHYG-1 cells to cisplatin (DDP), which was related to increased autophagy in the cells. In contrast, knockdown of LMP1 expression in SNK-6 cells promoted cellular sensitivity to DDP and reduced the autophagy of cells after DDP treatment. Moreover, specific inhibition of autophagy in KHYG-1 cells significantly attenuated the resistance to DDP caused by overexpression of LMP1, but treatment with rapamycin in SNK-6 cells significantly promoted the autophagy in the cells. Subsequently, overexpression of LMP1 promoted the activation of the MEK1/2-Nrf2 pathway in KYHG-1 cells, whereas knockdown of LMP1 in SNK-6 cells inhibited the activation of the MEK1/2-Nrf2 pathway. Inhibition of MEK1/2/Nrf-2 blocked the promoting effects of LMP1 on lymphoma cell resistance. In conclusion, EBV-LMP1 promotes cell autophagy after DDP treatment by activating the MEK1/2/Nrf-2 signaling pathway in lymphoma cells, thus, enhancing the resistance of lymphoma cells to DDP.

The epstein-barr virus latent membrane protein-1 (LMP1) induces interleukin-10 production in burkitt lymphoma lines

1994 ◽  
Vol 57 (2) ◽  
pp. 240-244 ◽  
Author(s):  
Hiroshi Nakagomi ◽  
Riccardo Dolcetti ◽  
Maria Teresa Bejarano ◽  
Pavel Pisa ◽  
Rolf Kiessling ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Burkitt Lymphoma ◽  
Epstein Barr Virus ◽  
Interleukin 10 ◽  
Latent Membrane Protein ◽  
Latent Membrane Protein 1 ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Latent Membrane Protein

Epstein-Barr virus latent membrane protein 1 mRNA is expressed in a significant proportion of patients with chronic lymphocytic leukemia

Cancer ◽  
2010 ◽  
Vol 116 (4) ◽  
pp. 880-887 ◽  
Author(s):  
Jeffrey J. Tarrand ◽  
Michael J. Keating ◽  
Apostolia M. Tsimberidou ◽  
Susan O'Brien ◽  
Rocco P. LaSala ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Significant Proportion ◽  
Latent Membrane Protein ◽  
Lymphocytic Leukemia ◽  
Latent Membrane Protein 1 ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Latent Membrane Protein

A role for protein kinase PKR in the mediation of Epstein–Barr virus latent membrane protein-1-induced IL-6 and IL-10 expression

Cytokine ◽  
2010 ◽  
Vol 50 (2) ◽  
pp. 210-219 ◽  
Author(s):  
San San Lin ◽  
Davy C.W. Lee ◽  
Anna H.Y. Law ◽  
Jun Wei Fang ◽  
Daniel T.T. Chua ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Membrane Protein ◽  
Epstein Barr Virus ◽  
Latent Membrane Protein ◽  
Latent Membrane Protein 1 ◽  
Barr Virus ◽  
Epstein Barr ◽  
Virus Latent Membrane Protein
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