scholarly journals Soluble Glycosaminoglycans Do Not Potentiate RANTES Antiviral Activity on the Infection of Primary Macrophages by Human Immunodeficiency Virus Type 1

Virology ◽  
2000 ◽  
Vol 278 (2) ◽  
pp. 412-422 ◽  
Author(s):  
Loyda Ylisastigui ◽  
Youssef Bakri ◽  
Saaïd Amzazi ◽  
Jean Claude Gluckman ◽  
Abdelaziz Benjouad
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiviral Activity ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus

scholarly journals The Thiocarboxanilide Nonnucleoside Inhibitor UC781 Restores Antiviral Activity of 3′-Azido-3′-Deoxythymidine (AZT) against AZT-Resistant Human Immunodeficiency Virus Type 1

1999 ◽  
Vol 43 (2) ◽  
pp. 259-263 ◽  
Author(s):  
Gadi Borkow ◽  
Dominique Arion ◽  
Mark A. Wainberg ◽  
Michael A. Parniak
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiviral Activity ◽  
Reverse Transcriptase ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Wild Type Virus ◽  
Wild Type ◽  
Immunodeficiency Virus ◽  
Hiv 1

ABSTRACT N-[4-Chloro-3-(3-methyl-2-butenyloxy)phenyl]-2-methyl-3-furancarbothioamide (UC781) is an exceptionally potent nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. We found that a 1:1 molar combination of UC781 and 3′-azido-3′-deoxythymidine (AZT) showed high-level synergy in inhibiting the replication of AZT-resistant virus, implying that UC781 can restore antiviral activity to AZT against AZT-resistant HIV-1. Neither the nevirapine plus AZT nor the 2′,5′-bis-O-(t-butyldimethylsilyl)-3′-spiro-5"-(4"-amino-1",2"-oxathiole-2",2"-dioxide plus AZT combinations had this effect. Studies with purified HIV-1 reverse transcriptase (from a wild type and an AZT-resistant mutant) showed that UC781 was a potent inhibitor of the pyrophosphorolytic cleavage of nucleotides from the 3′ end of the DNA polymerization primer, a process that we have proposed to be critical for the phenotypic expression of AZT resistance. Combinations of UC781 plus AZT did not act in synergy to inhibit the replication of either wild-type virus or UC781-resistant HIV-1. Importantly, the time to the development of viral resistance to combinations of UC781 plus AZT is significantly delayed compared to the time to the development of resistance to either drug alone.

scholarly journals Antiviral activity of polyoxomol ybdoeuropate PM-104 against human immunodeficiency virus type 1.

1991 ◽  
Vol 39 (6) ◽  
pp. 1638-1640 ◽  
Author(s):  
Yoshio INOUYE ◽  
Yoshiki TOKUTAKE ◽  
Tetsuya YOSHIDA ◽  
Akihiro YAMAMOTO ◽  
Toshihiro YAMASE ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiviral Activity ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus

Antiviral activity of Hawaiian medicinal plants against human immunodeficiency Virus Type-1 (HIV-1)

Phytomedicine ◽  
1996 ◽  
Vol 2 (3) ◽  
pp. 259-264 ◽  
Author(s):  
Christopher P. Locher ◽  
Myriam Witvrouw ◽  
Marie-Pierre De Béthune ◽  
Mark T. Burch ◽  
Howard F. Mower ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Medicinal Plants ◽  
Antiviral Activity ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus ◽  
Hiv 1
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