scholarly journals Downregulation of β1 Integrins by Ebola Virus Glycoprotein: Implication for Virus Entry

Virology ◽  
2000 ◽  
Vol 278 (1) ◽  
pp. 20-26 ◽  
Author(s):  
Ayato Takada ◽  
Shinji Watanabe ◽  
Hiroshi Ito ◽  
Katsunori Okazaki ◽  
Hiroshi Kida ◽  
...  
Keyword(s):  
Ebola Virus ◽  
Virus Entry ◽  
Virus Glycoprotein ◽  
Β1 Integrins

scholarly journals Characterization of the inhibitory effect of an extract of Prunella vulgaris on Ebola virus glycoprotein (GP)-mediated virus entry and infection

2016 ◽  
Vol 127 ◽  
pp. 20-31 ◽  
Author(s):  
Xu Zhang ◽  
Zhujun Ao ◽  
Alexander Bello ◽  
Xiaozhuo Ran ◽  
Shuiping Liu ◽  
...  
Keyword(s):  
Ebola Virus ◽  
Virus Entry ◽  
Inhibitory Effect ◽  
Prunella Vulgaris ◽  
Virus Glycoprotein

scholarly journals The Roles of Histidines and Charged Residues as Potential Triggers of a Conformational Change in the Fusion Loop of Ebola Virus Glycoprotein

PLoS ONE ◽  
2016 ◽  
Vol 11 (3) ◽  
pp. e0152527 ◽  
Author(s):  
Jinwoo Lee ◽  
Sonia M. Gregory ◽  
Elizabeth A. Nelson ◽  
Judith M. White ◽  
Lukas K. Tamm
Keyword(s):  
Conformational Change ◽  
Ebola Virus ◽  
Virus Glycoprotein ◽  
Charged Residues ◽  
Fusion Loop

scholarly journals Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor

Viruses ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 152 ◽  
Author(s):  
Qinghua Cui ◽  
Ruikun Du ◽  
Manu Anantpadma ◽  
Adam Schafer ◽  
Lin Hou ◽  
...  
Keyword(s):  
Ellagic Acid ◽  
Ebola Virus ◽  
Virus Entry ◽  
Rhodiola Rosea ◽  
Entry Inhibitor

scholarly journals Ebola virus glycoprotein directly triggers T lymphocyte death despite of the lack of infection

2017 ◽  
Vol 13 (5) ◽  
pp. e1006397 ◽  
Author(s):  
Mathieu Iampietro ◽  
Patrick Younan ◽  
Andrew Nishida ◽  
Mukta Dutta ◽  
Ndongala Michel Lubaki ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Ebola Virus ◽  
Virus Glycoprotein

scholarly journals Identification of Diaryl-Quinoline Compounds as Entry Inhibitors of Ebola Virus

Viruses ◽  
2018 ◽  
Vol 10 (12) ◽  
pp. 678 ◽  
Author(s):  
Qinghua Cui ◽  
Han Cheng ◽  
Rui Xiong ◽  
Gang Zhang ◽  
Ruikun Du ◽  
...  
Keyword(s):  
Drug Development ◽  
Ebola Virus ◽  
Virus Disease ◽  
Virus Entry ◽  
Surface Protein ◽  
Host Cells ◽  
Entry Inhibitor ◽  
Entry Inhibitors ◽  
Promising Target ◽  
Virus Entry Inhibitors

Ebola virus is the causative agent of Ebola virus disease in humans. The lethality of Ebola virus infection is about 50%, supporting the urgent need to develop anti-Ebola drugs. Glycoprotein (GP) is the only surface protein of the Ebola virus, which is functionally critical for the virus to attach and enter the host cells, and is a promising target for anti-Ebola virus drug development. In this study, using the recombinant HIV-1/Ebola pseudovirus platform we previously established, we evaluated a small molecule library containing various quinoline compounds for anti-Ebola virus entry inhibitors. Some of the quinoline compounds specifically inhibited the entry of the Ebola virus. Among them, compound SYL1712 was the most potent Ebola virus entry inhibitor with an IC50 of ~1 μM. The binding of SYL1712 to the vial glycoprotein was computationally modeled and was predicted to interact with specific residues of GP. We used the time of the addition assay to show that compound SYL1712 blocks Ebola GP-mediated entry. Finally, consistent with being an Ebola virus entry inhibitor, compound SYL1712 inhibited infectious Ebola virus replication in tissue culture under biosafety level 4 containment, with an IC50 of 2 μM. In conclusion, we identified several related molecules with a diaryl-quinoline scaffold as potential anti-EBOV entry inhibitors, which can be further optimized for anti-Ebola drug development.

scholarly journals The Ebola Virus Glycoprotein: An Essential Envelope Protein for the Life Cycle of Ebola Virus

2015 ◽  
Vol 29 (S1) ◽  
Author(s):  
James Foresman ◽  
Bill Lackamp ◽  
Adrian McAfee ◽  
Marie Montague ◽  
Daniel Mungula ◽  
...  
Keyword(s):  
Life Cycle ◽  
Envelope Protein ◽  
Ebola Virus ◽  
Virus Glycoprotein

scholarly journals A system for functional analysis of Ebola virus glycoprotein

1997 ◽  
Vol 94 (26) ◽  
pp. 14764-14769 ◽  
Author(s):  
A. Takada ◽  
C. Robison ◽  
H. Goto ◽  
A. Sanchez ◽  
K. G. Murti ◽  
...  
Keyword(s):  
Functional Analysis ◽  
Ebola Virus ◽  
Virus Glycoprotein
Sign in / Sign up

Export Citation Format

Share Document