scholarly journals Inhibition of Host RNA Polymerase II-Dependent Transcription by Vesicular Stomatitis Virus Results from Inactivation of TFIID

Virology ◽  
1998 ◽  
Vol 251 (2) ◽  
pp. 383-392 ◽  
Author(s):  
Hang Yuan ◽  
Barbara K. Yoza ◽  
Douglas S. Lyles
Keyword(s):  
Rna Polymerase ◽  
Rna Polymerase Ii ◽  
Vesicular Stomatitis Virus ◽  
Vesicular Stomatitis

scholarly journals Crystal Structure of the Oligomerization Domain of the Phosphoprotein of Vesicular Stomatitis Virus

2006 ◽  
Vol 80 (6) ◽  
pp. 2808-2814 ◽  
Author(s):  
Haitao Ding ◽  
Todd J. Green ◽  
Shanyun Lu ◽  
Ming Luo
Keyword(s):  
Crystal Structure ◽  
Rna Polymerase ◽  
Vesicular Stomatitis Virus ◽  
Additional Stabilization ◽  
Vesicular Stomatitis ◽  
L Proteins ◽  
Α Helix ◽  
Nucleoprotein N ◽  
Β Sheet ◽  
Viral Nucleocapsid

ABSTRACT In the replication cycle of nonsegmented negative-strand RNA viruses, the viral RNA-dependent RNA polymerase (L) recognizes a nucleoprotein (N)-enwrapped RNA template during the RNA polymerase reaction. The viral phosphoprotein (P) is a polymerase cofactor essential for this recognition. We report here the 2.3-Å-resolution crystal structure of the central domain (residues 107 to 177) of P from vesicular stomatitis virus. The fold of this domain consists of a β hairpin, an α helix, and another β hairpin. The α helix provides the stabilizing force for forming a homodimer, while the two β hairpins add additional stabilization by forming a four-stranded β sheet through domain swapping between two molecules. This central dimer positions the N- and C-terminal domains of P to interact with the N and L proteins, allowing the L protein to specifically recognize the nucleocapsid-RNA template and to progress along the template while concomitantly assembling N with nascent RNA. The interdimer interactions observed in the noncrystallographic packing may offer insight into the mechanism of the RNA polymerase processive reaction along the viral nucleocapsid-RNA template.

Inhibition of the RNA polymerase of vesicular stomatitis virus by ppp5′A2′p5′A and related compounds

1990 ◽  
Vol 13 (2) ◽  
pp. 81-89 ◽  
Author(s):  
Malathy Subramanian ◽  
Terez Kovacs ◽  
Krystyna Lesiak ◽  
Paul F. Torrence ◽  
John Lenard
Keyword(s):  
Rna Polymerase ◽  
Vesicular Stomatitis Virus ◽  
Vesicular Stomatitis ◽  
Related Compounds

Activation of the virion-associated RNA polymerase of vesicular stomatitis virus by melittin

1982 ◽  
Vol 105 (4) ◽  
pp. 1265-1271 ◽  
Author(s):  
Jayasri Roy ◽  
Pranab K. Chanda ◽  
George B. Thornton ◽  
Daniel Luk ◽  
Amiya K. Banerjee
Keyword(s):  
Rna Polymerase ◽  
Vesicular Stomatitis Virus ◽  
Vesicular Stomatitis
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