scholarly journals A Novel Human DnaJ Protein, hTid-1, a Homolog of the Drosophila Tumor Suppressor Protein Tid56, Can Interact with the Human Papillomavirus Type 16 E7 Oncoprotein

Virology ◽  
1998 ◽  
Vol 247 (1) ◽  
pp. 74-85 ◽  
Author(s):  
Boris Schilling ◽  
Tali De-Medina ◽  
Josh Syken ◽  
Marc Vidal ◽  
Karl Münger
Keyword(s):  
Human Papillomavirus ◽  
Tumor Suppressor ◽  
Tumor Suppressor Protein ◽  
E7 Oncoprotein ◽  
Human Papillomavirus Type 16 ◽  
Dnaj Protein

scholarly journals Stabilization and Functional Impairment of the Tumor Suppressor p53 by the Human Papillomavirus Type 16 E7 Oncoprotein

Virology ◽  
2002 ◽  
Vol 295 (1) ◽  
pp. 74-85 ◽  
Author(s):  
Alexandra Eichten ◽  
Matthew Westfall ◽  
Jennifer A. Pietenpol ◽  
Karl Münger
Keyword(s):  
Human Papillomavirus ◽  
Tumor Suppressor ◽  
Functional Impairment ◽  
Tumor Suppressor P53 ◽  
E7 Oncoprotein ◽  
Human Papillomavirus Type 16

scholarly journals Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.

1992 ◽  
Vol 66 (4) ◽  
pp. 2418-2427 ◽  
Author(s):  
W C Phelps ◽  
K Münger ◽  
C L Yee ◽  
J A Barnes ◽  
P M Howley
Keyword(s):  
Human Papillomavirus ◽  
Structure Function ◽  
Function Analysis ◽  
E7 Oncoprotein ◽  
Human Papillomavirus Type 16

scholarly journals Cervical Cancers Require the Continuous Expression of the Human Papillomavirus Type 16 E7 Oncoprotein Even in the Presence of the Viral E6 Oncoprotein

2012 ◽  
Vol 72 (16) ◽  
pp. 4008-4016 ◽  
Author(s):  
Sean F. Jabbar ◽  
Soyeong Park ◽  
Johannes Schweizer ◽  
Marthe Berard-Bergery ◽  
Henry C. Pitot ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Cervical Cancers ◽  
E7 Oncoprotein ◽  
Human Papillomavirus Type 16 ◽  
E6 Oncoprotein

Human Papillomavirus Type 16 E7 Oncoprotein Binds and Inactivates Growth-Inhibitory Insulin-Like Growth Factor Binding Protein 3

2000 ◽  
Vol 20 (17) ◽  
pp. 6483-6495
Author(s):  
Boris Mannhardt ◽  
Stuart A. Weinzimer ◽  
Mechthild Wagner ◽  
Marc Fiedler ◽  
Pinchas Cohen ◽  
...  
Keyword(s):  
Human Papillomavirus ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
E7 Oncoprotein ◽  
Human Papillomavirus Type 16 ◽  
Growth Inhibitory

scholarly journals Inactivation of Interferon Regulatory Factor-1 Tumor Suppressor Protein by HPV E7 Oncoprotein

2000 ◽  
Vol 275 (10) ◽  
pp. 6764-6769 ◽  
Author(s):  
Jong-Sup Park ◽  
Eun-Joo Kim ◽  
Ho-Jeong Kwon ◽  
Eun-Seong Hwang ◽  
Sung-Eun Namkoong ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Interferon Regulatory Factor ◽  
Tumor Suppressor Protein ◽  
Regulatory Factor ◽  
E7 Oncoprotein ◽  
Hpv E7 ◽  
Interferon Regulatory Factor 1

scholarly journals Human Papillomavirus Type 16 E7 Oncoprotein Associates with the Centrosomal Component γ-Tubulin

2007 ◽  
Vol 81 (24) ◽  
pp. 13533-13543 ◽  
Author(s):  
Christine L. Nguyen ◽  
Catherine Eichwald ◽  
Max L. Nibert ◽  
Karl Münger
Keyword(s):  
Human Papillomavirus ◽  
Gradient Centrifugation ◽  
Sucrose Density Gradient ◽  
Sucrose Density Gradient Centrifugation ◽  
E7 Oncoprotein ◽  
Human Papillomavirus Type 16 ◽  
Retinoblastoma Tumor Suppressor ◽  
Mitotic Abnormalities ◽  
Small Pool ◽  
Retinoblastoma Tumor

ABSTRACT Expression of a high-risk human papillomavirus (HPV) E7 oncoprotein is sufficient to induce aberrant centrosome duplication in primary human cells. The resulting centrosome-associated mitotic abnormalities have been linked to the development of aneuploidy. HPV type 16 (HPV16) E7 induces supernumerary centrosomes through a mechanism that is at least in part independent of the inactivation of the retinoblastoma tumor suppressor pRb and is dependent on cyclin-dependent kinase 2 activity. Here, we show that HPV16 E7 can concentrate around mitotic spindle poles and that a small pool of HPV16 E7 is associated with centrosome fractions isolated by sucrose density gradient centrifugation. The targeting of HPV16 E7 to the centrosome, however, was not sufficient for centrosome overduplication. Nonetheless, we found that HPV16 E7 can associate with the centrosomal regulator γ-tubulin and that the recruitment of γ-tubulin to the centrosome is altered in HPV16 E7-expressing cells. Since the association of HPV16 E7 with γ-tubulin is independent of pRb, p107, and p130, our results suggest that the association with γ-tubulin contributes to the pRb/p107/p130-independent ability of HPV16 E7 to subvert centrosome homeostasis.

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