scholarly journals Phosphorylation of Canine Distemper Virus P Protein by Protein Kinase C-ζ and Casein Kinase II

Virology ◽  
1997 ◽  
Vol 232 (1) ◽  
pp. 198-206 ◽  
Author(s):  
Zheng Liu ◽  
Clayton C. Huntley ◽  
Bishnu P. De ◽  
Tapas Das ◽  
Amiya K. Banerjee ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Canine Distemper Virus ◽  
Casein Kinase Ii ◽  
Casein Kinase ◽  
Canine Distemper ◽  
Kinase C ◽  
P Protein

Inhibition of protein kinase C- and casein kinase II-mediated phosphorylation of GAP-43 by S100β

1994 ◽  
Vol 25 (3-4) ◽  
pp. 297-304 ◽  
Author(s):  
Li-Hsien Lin ◽  
Linda J. Van Eldik ◽  
Neil Osheroff ◽  
Jeanette J. Norden
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Casein Kinase Ii ◽  
Casein Kinase ◽  
Kinase C

scholarly journals Conservedin VivoPhosphorylation of Calnexin at Casein Kinase II Sites as Well as a Protein Kinase C/Proline-directed Kinase Site

1998 ◽  
Vol 273 (27) ◽  
pp. 17227-17235 ◽  
Author(s):  
Hetty N. Wong ◽  
Malcolm A. Ward ◽  
Alexander W. Bell ◽  
Eric Chevet ◽  
Satty Bains ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Casein Kinase Ii ◽  
Casein Kinase ◽  
Kinase C

scholarly journals Purification and characterization of echinoderm casein kinase II. Regulation by protein kinase C

1992 ◽  
Vol 283 (3) ◽  
pp. 829-837 ◽  
Author(s):  
J S Sanghera ◽  
L A Charlton ◽  
H B Paddon ◽  
S L Pelech
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Casein Kinase Ii ◽  
Casein Kinase ◽  
Beta Subunit ◽  
Alpha Subunit ◽  
Sea Star ◽  
Sequential Fractionation ◽  
Germinal Vesicle Breakdown ◽  
Kinase C

Casein kinase II (CKII) is one of several protein kinases that become activated before germinal-vesicle breakdown in maturing sea-star oocytes. Echinoderm CKII was purified over 11,000-fold with a recovery of approximately 10% by sequential fractionation of the oocyte cytosol on tyrosine-agarose, heparin-agarose, casein-agarose and MonoQ. The purified enzyme contained 45, 38 and 28 kDa polypeptides, which corresponded to its alpha, alpha' and beta subunits respectively. The beta-subunit was autophosphorylated on one major tryptic peptide on serine residues, whereas the alpha'-subunit incorporated phosphate into at least two tryptic peptides primarily on threonine residues. Western-blotting analysis of sea-star oocyte extracts with two different anti-peptide antibodies that recognized conserved regions of the alpha-subunit indicated that the protein levels of the alpha- and alpha'-subunits of CKII were unchanged during oocyte maturation. The purified CKII was partly inactivated (by 25%) by preincubation with protein-serine/threonine phosphatase 2A, but protein-tyrosine phosphatases had no effect. The beta-subunit of CKII was phosphorylated on a serine residue(s) up to 0.54 mol of P/mol of beta-subunit by purified protein kinase C, and this correlated with a 1.5-fold enhancement of its phosphotransferase activity with phosvitin as a substrate. CKII was not a substrate for the maturation-activated myelin basic protein kinase p44mpk from sea-star oocytes, nor for cyclic-AMP-dependent protein kinase. These studies point to possible regulation of CKII by protein phosphorylation.

2133-P: Protein Kinase C Delta Mediates Cytokine-Induced Apoptosis in the Pancreatic Beta Cell

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2133-P
Author(s):  
NIKKI L. FARNSWORTH ◽  
ROBERT A. PISCOPIO ◽  
RICHARD K. BENNINGER
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Protein Kinase C Delta ◽  
Kinase C ◽  
P Protein ◽  
Induced Apoptosis

scholarly journals Targeted disruption of PKC from AKAP Signaling Complexes

2021 ◽  
Author(s):  
Ameya J. Limaye ◽  
George N. Bendzunas ◽  
Eileen Kennedy
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
Signaling Pathways ◽  
Protein Interactions ◽  
Protein Protein Interactions ◽  
Targeted Disruption ◽  
Physiological Processes ◽  
Kinase C ◽  
P Protein

Protein Kinase C (PKC) is a member of the AGC subfamily of kinases and regulates a wide array of signaling pathways and physiological processes. Protein-protein interactions involving PKC and its...

Sign in / Sign up

Export Citation Format

Share Document