Propanil Inhibits Tumor Necrosis Factor-α Production by Reducing Nuclear Levels of the Transcription Factor Nuclear Factor-κB in the Macrophage Cell Line IC-21

2001 ◽  
Vol 172 (3) ◽  
pp. 186-193 ◽  
Author(s):  
Laura L. Frost ◽  
Yilin Xie Neeley ◽  
Rosana Schafer ◽  
Laura F. Gibson ◽  
John B. Barnett
Keyword(s):  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Nuclear Levels ◽  
Factor Α ◽  
Transcription Factor Nuclear Factor ◽  
Necrosis Factor

I. TNF-induced liver injury

1998 ◽  
Vol 275 (3) ◽  
pp. G387-G392 ◽  
Author(s):  
Cynthia A. Bradham ◽  
Jörg Plümpe ◽  
Michael P. Manns ◽  
David A. Brenner ◽  
Christian Trautwein
Keyword(s):  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Nuclear Factor Κb ◽  
Hepatocyte Proliferation ◽  
Nuclear Factor ◽  
Normal Hepatocyte ◽  
Tnf Α ◽  
Factor Α ◽  
Transcription Factor Nuclear Factor ◽  
Necrosis Factor

Tumor necrosis factor-α (TNF-α) functions as a two-edged sword in the liver. TNF-α is required for normal hepatocyte proliferation during liver regeneration. It functions both as a comitogen and to induce the transcription factor nuclear factor-κB, which has antiapoptotic effects. On the other hand, TNF-α is the mediator of hepatotoxicity in many animal models, including those involving the toxins concanavalin A and lipopolysaccharide. TNF-α has also been implicated as an important pathogenic mediator in patients with alcoholic liver disease and viral hepatitis.

Mutant p53 Enhances Nuclear Factor κB Activation by Tumor Necrosis Factor α in Cancer Cells

2007 ◽  
Vol 67 (6) ◽  
pp. 2396-2401 ◽  
Author(s):  
Lilach Weisz ◽  
Alexander Damalas ◽  
Michalis Liontos ◽  
Panagiotis Karakaidos ◽  
Giulia Fontemaggi ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Cancer Cells ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Nuclear Factor Κb ◽  
Mutant P53 ◽  
Nuclear Factor ◽  
Factor Α ◽  
Necrosis Factor

scholarly journals Activation of Transcriptionally Active Nuclear Factor-κB by Tumor Necrosis Factor-α and Its Inhibition by Antioxidants in Rat Thyroid FRTL-5 Cells1

Endocrinology ◽  
1998 ◽  
Vol 139 (4) ◽  
pp. 1715-1722 ◽  
Author(s):  
Toyone Kikumori ◽  
Fukushi Kambe ◽  
Takashi Nagaya ◽  
Tsuneo Imai ◽  
Hiroomi Funahashi ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Nuclear Factor Κb ◽  
Nuclear Factor ◽  
Rat Thyroid ◽  
Factor Α ◽  
Necrosis Factor
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