Relative Potency Values Derived from Hepatic Vitamin A Reduction in Male and Female Sprague–Dawley Rats Following Subchronic Dietary Exposure to Individual Polychlorinated Dibenzo-p-dioxin and Dibenzofuran Congeners and a Mixture Thereof

2000 ◽  
Vol 165 (3) ◽  
pp. 184-194 ◽  
Author(s):  
Elena Fattore ◽  
Christina Trossvik ◽  
Helen Håkansson
Keyword(s):  
Vitamin A ◽  
Dietary Exposure ◽  
Relative Potency ◽  
Sprague Dawley ◽  
Male And Female ◽  
Sprague Dawley Rats

Ultrastructural investigation of spontaneous pituitary gonadotroph cell adenomas in aging Sprague-Dawley rats

1983 ◽  
Vol 41 ◽  
pp. 702-703
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Epoxy Resin ◽  
Immunoelectron Microscopy ◽  
Tumor Type ◽  
Gonadal Function ◽  
Sprague Dawley ◽  
Male And Female ◽  
Reticulin Fibers ◽  
Sprague Dawley Rats

Gonadotroph cell adenomas of the pituitary are infrequent in human patients and are not invariably associated with altered gonadal function. To date, no animal model of this tumor type exists. Herein, we describe spontaneous gonadotroph cell adenomas in old male and female Sprague-Dawley rats by histology, immunocytology and electron microscopy.The material consisted of the pituitaries of 27 male and 38 female Sprague Dawley rats, all 26 months of age or older, removed at routine autopsy. Sections of formal in-fixed, paraffin-embedded tissue were stained with hematoxylin-phloxine-saffron (HPS), the PAS method and the Gordon-Sweet technique for the demonstration of reticulin fibers. For immunostaining, sections were exposed to anti-rat β-LH, anti-ratβ-TSH, anti-rat PRL, anti-rat GH and anti-rat ACTH 1-39. For electron microscopy, tissue was fixed in 2.5% glutaraldehyde, postfixed in 1% OsO4 and embedded in epoxy-resin. Tissue fixed in 10% formalin, embedded in epoxy resin without osmification, was used for immunoelectron microscopy.

Hepatic effects of a highly purified PCB 180 in adult male and female Sprague–Dawley rats

2008 ◽  
Vol 180 ◽  
pp. S39-S40
Author(s):  
Robert Roos ◽  
Patrik Andersson ◽  
Päivi Heikkinen ◽  
Hans-Joachim Schmitz ◽  
Leo van der Ven ◽  
...  
Keyword(s):  
Adult Male ◽  
Sprague Dawley ◽  
Male And Female ◽  
Sprague Dawley Rats

Dietary exposure to silver nanoparticles in Sprague–Dawley rats: Effects on oxidative stress and inflammation

2013 ◽  
Vol 60 ◽  
pp. 297-301 ◽  
Author(s):  
R. Ebabe Elle ◽  
S. Gaillet ◽  
J. Vidé ◽  
C. Romain ◽  
C. Lauret ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Silver Nanoparticles ◽  
Dietary Exposure ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Relative equivalence of CNS safety (FOB) assessment outcomes in male and female Wistar-Han and Sprague-Dawley rats

2019 ◽  
Vol 95 ◽  
pp. 2-11 ◽  
Author(s):  
David V. Gauvin ◽  
Jill A. Dalton ◽  
Marci L. Harter ◽  
David Holdsworth ◽  
Jonelle May ◽  
...  
Keyword(s):  
Sprague Dawley ◽  
Male And Female ◽  
Sprague Dawley Rats ◽  
Assessment Outcomes

Metabolism and disposition of [14C]n-butyl-p-hydroxybenzoate in male and female Harlan Sprague Dawley rats following oral administration and dermal application

Xenobiotica ◽  
2012 ◽  
Vol 43 (2) ◽  
pp. 169-181 ◽  
Author(s):  
James M. Mathews ◽  
Sherri S. Brown ◽  
Purvi R. Patel ◽  
Sherry R. Black ◽  
Troy T. Banks ◽  
...  
Keyword(s):  
Oral Administration ◽  
Sprague Dawley ◽  
Male And Female ◽  
Sprague Dawley Rats ◽  
Dermal Application
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