Gestational Exposure to Chlorpyrifos: Apparent Protection of the Fetus?

1998 ◽  
Vol 152 (1) ◽  
pp. 56-65 ◽  
Author(s):  
T.L. Lassiter ◽  
S. Padilla ◽  
S.R. Mortensen ◽  
S.M. Chanda ◽  
V.C. Moser ◽  
...  
Keyword(s):  
Gestational Exposure

#50 Gestational exposure of tumor necrosis factor-α (TNF-α) inhibitor drugs

2019 ◽  
Vol 88 ◽  
pp. 149-150 ◽  
Author(s):  
Erkoseoglu Ilknur ◽  
Kadioglu Mine ◽  
Cavusoglu Irem ◽  
Sisman Mulkiye ◽  
Aran Turhan ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Α ◽  
Gestational Exposure ◽  
Tnf Α ◽  
Factor Α ◽  
Necrosis Factor

Gestational exposure to Δ9-THC impacts ovarian follicular dynamics and angiogenesis in adulthood in Wistar rats

2021 ◽  
pp. 1-5
Author(s):  
Annia A. Martínez-Peña ◽  
Kendrick Lee ◽  
James J. Petrik ◽  
Daniel B. Hardy ◽  
Alison C. Holloway
Keyword(s):  
Reproductive Health ◽  
Cannabis Sativa ◽  
Follicular Development ◽  
Angiogenic Factor ◽  
Postnatal Life ◽  
Adult Rat ◽  
Female Reproductive Health ◽  
Gestational Exposure ◽  
Follicular Dynamics

Abstract With the legalization of marijuana (Cannabis sativa) and increasing use during pregnancy, it is important to understand its impact on exposed offspring. Specifically, the effects of Δ-9-tetrahydrocannabinol (Δ9-THC), the major psychoactive component of cannabis, on fetal ovarian development and long-term reproductive health are not fully understood. The aim of this study was to assess the effect of prenatal exposure to Δ9-THC on ovarian health in adult rat offspring. At 6 months of age, Δ9-THC-exposed offspring had accelerated folliculogenesis with apparent follicular development arrest, but no persistent effects on circulating steroid levels. Ovaries from Δ9-THC-exposed offspring had reduced blood vessel density in association with decreased expression of the pro-angiogenic factor VEGF and its receptor VEGFR-2, as well as an increase in the anti-angiogenic factor thrombospondin 1 (TSP-1). Collectively, these data suggest that exposure to Δ9-THC during pregnancy alters follicular dynamics during postnatal life, which may have long-lasting detrimental effects on female reproductive health.

Developmental toxicity of lead in rats after gestational exposure and the protective role of taurine

2021 ◽  
Author(s):  
Hoda Samir Aglan ◽  
Marwa M Safar ◽  
Afaf Abdel‐Moniem Ain‐Shoka ◽  
Asmaa Munir Kandil ◽  
Samuel Gebremedhn ◽  
...  
Keyword(s):  
Developmental Toxicity ◽  
Protective Role ◽  
Gestational Exposure

scholarly journals Relationship between Autism Spectrum Disorder and Pesticides: A Systematic Review of Human and Preclinical Models

2021 ◽  
Vol 18 (10) ◽  
pp. 5190
Author(s):  
Judit Biosca-Brull ◽  
Cristian Pérez-Fernández ◽  
Santiago Mora ◽  
Beatriz Carrillo ◽  
Helena Pinos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Autism Spectrum Disorder ◽  
Experimental Studies ◽  
Clinical Signs ◽  
Epidemiological Studies ◽  
Autism Spectrum ◽  
Spectrum Disorder ◽  
Preclinical Studies ◽  
Preclinical Models ◽  
Gestational Exposure

Autism spectrum disorder (ASD) is a complex set of neurodevelopmental pathologies characterized by impoverished social and communicative abilities and stereotyped behaviors. Although its genetic basis is unquestionable, the involvement of environmental factors such as exposure to pesticides has also been proposed. Despite the systematic analyses of this relationship in humans, there are no specific reviews including both human and preclinical models. The present systematic review summarizes, analyzes, and discusses recent advances in preclinical and epidemiological studies. We included 45 human and 16 preclinical studies. These studies focused on Organophosphates (OP), Organochlorine (OC), Pyrethroid (PT), Neonicotinoid (NN), Carbamate (CM), and mixed exposures. Preclinical studies, where the OP Chlorpyrifos (CPF) compound is the one most studied, pointed to an association between gestational exposure and increased ASD-like behaviors, although the data are inconclusive with regard to other ages or pesticides. Studies in humans focused on prenatal exposure to OP and OC agents, and report cognitive and behavioral alterations related to ASD symptomatology. The results of both suggest that gestational exposure to certain OP agents could be linked to the clinical signs of ASD. Future experimental studies should focus on extending the analysis of ASD-like behaviors in preclinical models and include exposure patterns similar to those observed in human studies.

scholarly journals Latent Immunological Effects of Gestational Exposure to Heptachlor Epoxide

Epidemiology ◽  
2011 ◽  
Vol 22 ◽  
pp. S148-S149
Author(s):  
Dean Baker ◽  
Haiou Yang ◽  
Ulrike Luderer ◽  
Sastry Gollapudi
Keyword(s):  
Heptachlor Epoxide ◽  
Gestational Exposure ◽  
Immunological Effects

scholarly journals Gestational exposure to perfluorooctanoic acid (PFOA): Alterations in motor related behaviors

2017 ◽  
Vol 58 ◽  
pp. 110-119 ◽  
Author(s):  
David R. Goulding ◽  
Sally S. White ◽  
Sandra J. McBride ◽  
Suzanne E. Fenton ◽  
G. Jean Harry
Keyword(s):  
Perfluorooctanoic Acid ◽  
Gestational Exposure

Pregnancy loss and eye malformations in offspring of F344 rats following gestational exposure to mixtures of regulated trihalomethanes and haloacetic acids

2011 ◽  
Vol 31 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Michael G. Narotsky ◽  
Deborah S. Best ◽  
Anthony McDonald ◽  
Elizabeth A. Godin ◽  
E. Sidney Hunter ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Haloacetic Acids ◽  
Gestational Exposure ◽  
F344 Rats
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