Role of Glucocorticoids in Ethanol-Induced Decreases in Expression of MHC Class II Molecules on B Cells and Selective Decreases in Spleen Cell Number

1996 ◽  
Vol 139 (1) ◽  
pp. 153-162 ◽  
Author(s):  
Paul A. Weiss ◽  
Stephanie D. Collier ◽  
Stephen B. Pruett
Keyword(s):  
B Cells ◽  
Spleen Cell ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Cell Number ◽  
Mhc Class Ii Molecules

Role of Newly Synthesized MHC Class II Molecules in Antigen-Specific Antigen Presentation by B cells

Immunobiology ◽  
1995 ◽  
Vol 193 (1) ◽  
pp. 42-58 ◽  
Author(s):  
Takehiro Kokuho ◽  
Hideo Nariuchi ◽  
Yuichi Gyotoku ◽  
Terutaka Kakiuchi
Keyword(s):  
B Cells ◽  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Specific Antigen ◽  
Class Ii ◽  
Mhc Class Ii Molecules

scholarly journals Major histocompatibility complex-restricted recognition of retroviral superantigens by V beta 17+ T cells.

1992 ◽  
Vol 176 (1) ◽  
pp. 275-280 ◽  
Author(s):  
M A Blackman ◽  
F E Lund ◽  
S Surman ◽  
R B Corley ◽  
D L Woodland
Keyword(s):  
T Cells ◽  
Major Histocompatibility Complex ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Major Histocompatibility ◽  
Direct Role ◽  
Histocompatibility Complex ◽  
Class Ii Mhc ◽  
Mhc Class Ii Molecules

It has been established that at least some V beta 17+ T cells interact with an endogenous superantigen encoded by the murine retrovirus, Mtv-9. To analyze the role of major histocompatibility complex (MHC) class II molecules in presenting the Mtv-9 encoded superantigen, vSAG-9 to V beta 17+ hybridomas, a panel of nine hybridomas was tested for their ability to respond to A20/2J (H-2d) and LBK (H-2a) cells which had been transfected with the vSAG-9 gene. Whereas some of the hybridomas recognized vSAG-9 exclusively in the context of H-2a, other hybridomas recognized vSAG-9 exclusively in the context of H-2d or in the context of both H-2d and H-2a. These results suggest that: (a) the class II MHC molecule plays a direct role in the recognition of retroviral superantigen by T cells, rather than serving simply as a platform for presentation; and, (b) it is likely that components of the TCR other than V beta are involved in the vSAG-9/TCR/class II interaction.

scholarly journals Both IFN-γ and IL-4 Induce MHC Class II Expression at the Surface of Mouse Pro-B Cells

1997 ◽  
Vol 5 (2) ◽  
pp. 115-120 ◽  
Author(s):  
Suzanne Lombard-Platet ◽  
Valerie Meyer ◽  
Rhodri Ceredig
Keyword(s):  
B Cells ◽  
B Cell ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Invariant Chain ◽  
B Cell Differentiation ◽  
Cell Clones ◽  
Ifn Γ ◽  
B Lymphoid ◽  
Mhc Class Ii Molecules

Pro-B cells are early B-cell progenitors that retain macrophage potential. We have studied MHC class II molecules and invariant chain inducibility on four class II negative mouse pro- B-cell clones. We analyzed the effects of IL-4 and IFN-γ, which represent the major inducers of class II in the B-lymphoid and monocytic/macrophage lineages, respectively. After 48 h of treatment with either cytokine, three pro-B-cell clones (C2.13, A1.5, and F2.2) expressed intracellular invariant chain and cell-surface class II molecules. One clone (D2.1) remained negative. As already reported, more differentiated 70Z/3 pre-B cells were inducible by IL-4 only. These data suggest that the induction of class II and invariant-chain genes are subject to regulation throughout B-cell differentiation.

The role of HLA-DM for loading and selection of the peptide repertoire of MHC class-II molecules

1997 ◽  
Vol 56 ◽  
pp. 236
Author(s):  
H. Kropshofer ◽  
A.B. Vogt ◽  
G. Moldenhauer ◽  
O. Arndt ◽  
G.J. Hämmerling
Keyword(s):  
Mhc Class Ii ◽  
Class Ii ◽  
Mhc Class Ii Molecules ◽  
Selection Of

scholarly journals CD4+ T cell responses in mice lacking MHC class II molecules specifically on B cells

1998 ◽  
Vol 28 (11) ◽  
pp. 3763-3772 ◽  
Author(s):  
G. Stuart Williams ◽  
Annette Oxenius ◽  
Hans Hengartner ◽  
Christophe Benoist ◽  
Diane Mathis
Keyword(s):  
T Cell ◽  
B Cells ◽  
Mhc Class Ii ◽  
T Cell Responses ◽  
Class Ii ◽  
Cd4 T Cell ◽  
Cell Responses ◽  
Mhc Class Ii Molecules

scholarly journals Major Histocompatibility Complex Class II Compartments in Human and Mouse B Lymphoblasts Represent Conventional Endocytic Compartments

1997 ◽  
Vol 139 (3) ◽  
pp. 639-649 ◽  
Author(s):  
Monique J. Kleijmeer ◽  
Stanislaw Morkowski ◽  
Janice M. Griffith ◽  
Alexander Y. Rudensky ◽  
Hans J. Geuze
Keyword(s):  
Major Histocompatibility Complex ◽  
B Cells ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Invariant Chain ◽  
Histocompatibility Complex ◽  
Peptide Complexes ◽  
Endocytic Compartments ◽  
Human And Mouse ◽  
Mhc Class Ii Molecules

In most human and mouse antigen-presenting cells, the majority of intracellular major histocompatibility complex (MHC) class II molecules resides in late endocytic MHC class II compartments (MIICs), thought to function in antigen processing and peptide loading. However, in mouse A20 B cells, early endocytic class II-containing vesicles (CIIVs) have been reported to contain most of the intracellular MHC class II molecules and have also been implicated in formation of MHC class II–peptide complexes. To address this discrepancy, we have studied in great detail the endocytic pathways of both a human (6H5.DM) and a mouse (A20.Ab) B cell line. Using quantitative immunoelectron microscopy on cryosections of cells that had been pulse–chased with transferrin-HRP or BSA-gold as endocytic tracers, we have identified up to six endocytic subcompartments including an early MIIC type enriched in invariant chain, suggesting that it serves as an important entrance to the endocytic pathway for newly synthesized MHC class II/invariant chain complexes. In addition, early MIICs represented the earliest endocytic compartment containing MHC class II– peptide complexes, as shown by using an antibody against an abundant endogenous class II–peptide complex. The early MIIC exhibited several though not all of the characteristics reported for the CIIV and was situated just downstream of early endosomes. We have not encountered any special class II-containing endocytic structures besides those normally present in nonantigen-presenting cells. Our results therefore suggest that B cells use conventional endocytic compartments rather than having developed a unique compartment to accomplish MHC class II presentation.

3.2-06 The role of signalling through the cytoplasmic domains of MHC class II molecules in antigen presentation

1989 ◽  
Vol 26 ◽  
pp. 19
Author(s):  
Y St-Pierre ◽  
N Navabi ◽  
Z Ghogawala ◽  
L.H Glimcher ◽  
T.H Watts
Keyword(s):  
Antigen Presentation ◽  
Mhc Class Ii ◽  
Class Ii ◽  
Cytoplasmic Domains ◽  
Mhc Class Ii Molecules
Sign in / Sign up

Export Citation Format

Share Document