Intracellular signals and the cytoskeleton: the interactions of phosphoinositide kinases and small G proteins in adherence, ruffling and motility

1996 ◽  
Vol 7 (5) ◽  
pp. 691-697 ◽  
Author(s):  
Christopher L. Carpenter
Keyword(s):  
G Proteins ◽  
Intracellular Signals ◽  
Small G Proteins

scholarly journals Regulated CD44 Cleavage under the Control of Protein Kinase C, Calcium Influx, and the Rho Family of Small G Proteins

1999 ◽  
Vol 274 (36) ◽  
pp. 25525-25534 ◽  
Author(s):  
Isamu Okamoto ◽  
Yoshiaki Kawano ◽  
Mitsuhiro Matsumoto ◽  
Moritaka Suga ◽  
Kozo Kaibuchi ◽  
...  
Keyword(s):  
Protein Kinase C ◽  
Protein Kinase ◽  
G Proteins ◽  
Calcium Influx ◽  
Kinase C ◽  
Rho Family ◽  
Small G Proteins

Multiple mechanisms of receptor-G protein signaling specificity

1995 ◽  
Vol 269 (2) ◽  
pp. F141-F158 ◽  
Author(s):  
J. R. Raymond
Keyword(s):  
G Protein ◽  
G Proteins ◽  
Linear Models ◽  
G Protein Signaling ◽  
Protein Signaling ◽  
Heterotrimeric G Proteins ◽  
Cellular Functions ◽  
Signaling Specificity ◽  
Intracellular Signals ◽  
Specific Manner

The hormone-receptor-G protein complex transduces extracellular information into intracellular signals that ultimately regulate cellular functions in a highly specific manner. There are hundreds of receptor types that transduce signals through a relatively limited repertoire of heterotrimeric G proteins. Linear models of signaling specificity that require specific and highly selective coupling of hormone to receptor to G protein have proven inadequate to explain how highly particular signals are funneled through the G protein "bottleneck." Recent studies have uncovered a plethora of mechanisms that contribute to signaling specificity. This review focuses on the mechanisms that contribute to specificity in the interactions of receptors with G proteins.

Identification of Rgl3 as a potential binding partner for Rap-family small G-proteins and profilin II

2007 ◽  
Vol 19 (7) ◽  
pp. 1575-1582 ◽  
Author(s):  
Jiegou Xu ◽  
Shuliang Shi ◽  
Naoya Matsumoto ◽  
Makoto Noda ◽  
Hitoshi Kitayama
Keyword(s):  
G Proteins ◽  
Binding Partner ◽  
Potential Binding ◽  
Small G Proteins

scholarly journals Roco Proteins and the Parkinson’s Disease-Associated LRRK2

2018 ◽  
Vol 19 (12) ◽  
pp. 4074 ◽  
Author(s):  
Jingling Liao ◽  
Quyen Hoang
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
G Proteins ◽  
Conformational Changes ◽  
Effector Proteins ◽  
Cellular Processes ◽  
Current State ◽  
Specific Effector ◽  
Unique Domain ◽  
Small G Proteins

Small G-proteins are structurally-conserved modules that function as molecular on-off switches. They function in many different cellular processes with differential specificity determined by the unique effector-binding surfaces, which undergo conformational changes during the switching action. These switches are typically standalone monomeric modules that form transient heterodimers with specific effector proteins in the ‘on’ state, and cycle to back to the monomeric conformation in the ‘off’ state. A new class of small G-proteins called “Roco” was discovered about a decade ago; this class is distinct from the typical G-proteins in several intriguing ways. Their switch module resides within a polypeptide chain of a large multi-domain protein, always adjacent to a unique domain called COR, and its effector kinase often resides within the same polypeptide. As such, the mechanisms of action of the Roco G-proteins are likely to differ from those of the typical G-proteins. Understanding these mechanisms is important because aberrant activity in the human Roco protein LRRK2 is associated with the pathogenesis of Parkinson’s disease. This review provides an update on the current state of our understanding of the Roco G-proteins and the prospects of targeting them for therapeutic purposes.

scholarly journals The Roles of Rasd1 small G proteins and leptin in the activation of TRPC4 transient receptor potential channels

Channels ◽  
2015 ◽  
Vol 9 (4) ◽  
pp. 186-195
Author(s):  
Jinhong Wie ◽  
Byung Joo Kim ◽  
Jongyun Myeong ◽  
Kotdaji Ha ◽  
Seung Joo Jeong ◽  
...  
Keyword(s):  
G Proteins ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Transient Receptor Potential Channels ◽  
Potential Channels ◽  
Transient Receptor ◽  
Small G Proteins

scholarly journals GEFs and GAPs: Critical Elements in the Control of Small G Proteins

Cell ◽  
2007 ◽  
Vol 130 (2) ◽  
pp. 385 ◽  
Author(s):  
Johannes L. Bos ◽  
Holger Rehmann ◽  
Alfred Wittinghofer
Keyword(s):  
G Proteins ◽  
Critical Elements ◽  
Small G Proteins
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