Mutational Site

2001 ◽  
pp. 1285
Author(s):  
F.W. Stahl
Keyword(s):  
Mutational Site

Effect of temperature on transition and transversion mutagenesis: characterization of wild type and a mutator T4 DNA polymerase mutant

1984 ◽  
Vol 26 (3) ◽  
pp. 386-389 ◽  
Author(s):  
Linda J. Reha-Krantz ◽  
Sükran Parmaksizoglu
Keyword(s):  
Dna Polymerase ◽  
Low Temperatures ◽  
Bacteriophage T4 ◽  
Effect Of Temperature ◽  
In Vitro Mutagenesis ◽  
Wild Type ◽  
Mutational Site

The effect of temperature on genetically well-defined mutational pathways was examined in the bacteriophage T4. The mutational site was a T4 rII ochre mutant which could revert to rII+ via a transversion or to the amber convertant via a transition. Temperature did not strongly affect any of the pathways examined in a wild-type background; however, increased temperature reduced the mutational activity of a mutator DNA polymerase mutant. Possible models to explain the role of temperature in mutagenesis are discussed as well as the significance of low temperatures for in vitro mutagenesis reactions.Key words: bacteriophage T4, mutator, transition, transversion, temperature effects.

scholarly journals Mutational site in tunicamycin-resistant mutation tmrB8 of Bacillus subtilis as revealed at the nucleotide sequence level.

1988 ◽  
Vol 52 (3) ◽  
pp. 863-864
Author(s):  
Akihiko TANIMOTO ◽  
Shigeyoshi HARADA ◽  
Masaki MORI ◽  
Noboru YAMAJI ◽  
Kunio YAMANE ◽  
...  
Keyword(s):  
Bacillus Subtilis ◽  
Nucleotide Sequence ◽  
Nucleotide Sequence Level ◽  
Mutational Site ◽  
Resistant Mutation

scholarly journals Identification of a polymorphic site as a mutational site in exon VI of the mouse p53 gene

1993 ◽  
Author(s):  
T. Paunesku ◽  
M.A. Gemmell ◽  
R. Crkvenjakov ◽  
G.E. Woloschak
Keyword(s):  
P53 Gene ◽  
Polymorphic Site ◽  
Mutational Site

scholarly journals B6.C-H-2bm12. A new H-2 mutation in the I region in the mouse.

1979 ◽  
Vol 150 (6) ◽  
pp. 1323-1338 ◽  
Author(s):  
I F McKenzie ◽  
G M Morgan ◽  
M S Sandrin ◽  
M M Michaelides ◽  
R W Melvold ◽  
...  
Keyword(s):  
Strong Evidence ◽  
Mixed Lymphocyte Reaction ◽  
Absorption Analysis ◽  
Serological Analysis ◽  
Gene Complementation ◽  
Mutational Site ◽  
The One ◽  
Relationship Of ◽  
The Relationship ◽  
Ir Genes

The B6.C-H-2bm12 mutant is described and evidence is presented for the mutational site occurring in the IA subregion. The mutant is of the gain and loss type as bm12 in equilibrium or formed from C57BL/6 grafts are rejected in 14-16 d. Mapping studies by the gene-complementation method using H-2 recombinant strains place the mutation in the K or IA regions of the H-2 complex and furthermore, the use of this test and the use of other H-2 mutants indicate that H-2Kb is not the site of the mutation, making the IA region the most likely site. Serological analysis with a battery of H-2b, Iab, and other Ia sera, both by cytotoxicity, rosetting, and also by absorption analysis, indicated no alteration in H-2 specificities, particularly in H-2.K33. By contrast, all of the Iab specificities coded for by the IA subregion (Ia.3, 8, 9, 15, and possibly 20) are extensively altered and are either absent or greatly reduced in amount indicating an extensive alteration in the Ia-bearing molecule. The bm12 mutant strongly stimulates the parental C57BL/6 strain in an mixed lymphocyte reaction (MLR), and the reciprocal also occurs, the degree of stimulation being similar to that obtained with K + IA differences originating in another H-2 haplotype and points to the mutation effecting the Lad-1 locus. The presence of an extensive histocompatibility change, a marked alteration in the serologically detected Ia specificities, and a strong MLR, all produced by the one mutation, provides strong evidence for the identity of the Ia-1, Lad-1, and H-2(IA) loci in the IA subregion. The bm12 mutant should be of value in determining the relationship of Ia specificities, Ir genes, and other phenomena effected by the I region.

scholarly journals Mutational Site in Tunicamycinresistant MutationtmrB8ofBacillus subtilisas Revealed at the Nucleotide Sequence Level

1988 ◽  
Vol 52 (3) ◽  
pp. 863-864
Author(s):  
Akihiko Tanimoto ◽  
Shigeyoshi Harada ◽  
Masaki Mori ◽  
Noboru Yamaji ◽  
Kunio Yamane ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Nucleotide Sequence Level ◽  
Mutational Site

Case of mild Schmid-type metaphyseal chondrodysplasia with novel sequence variation involving an unusual mutational site of the COL10A1 gene

2015 ◽  
Vol 58 (3) ◽  
pp. 175-179 ◽  
Author(s):  
Hyunwoong Park ◽  
Susie Hong ◽  
Sung Im Cho ◽  
Tae-Joon Cho ◽  
In Ho Choi ◽  
...  
Keyword(s):  
Sequence Variation ◽  
Metaphyseal Chondrodysplasia ◽  
Col10a1 Gene ◽  
Mutational Site
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