Quantitative Whole-Body Radioluminography—Future Strategy for Balance and Tissue Distribution Studies

2000 ◽  
Vol 31 (2) ◽  
pp. S57-S62 ◽  
Author(s):  
Roland d'Argy ◽  
Anders Sundwall
Keyword(s):  
Tissue Distribution ◽  
Whole Body ◽  
Future Strategy ◽  
Distribution Studies

scholarly journals The synthesis of [14C]streptozotocin and its distribution and excretion in the rat

1974 ◽  
Vol 142 (3) ◽  
pp. 673-683 ◽  
Author(s):  
Eric H. Karunanayake ◽  
David J. Hearse ◽  
Graham Mellows
Keyword(s):  
Biological Activity ◽  
Tissue Distribution ◽  
Renal Clearance ◽  
Dose Response ◽  
Whole Body ◽  
Response Curves ◽  
Intestinal Excretion ◽  
Metabolic Transformation ◽  
Distribution Studies

[14C]Streptozotocin was synthesized specifically labelled at three positions in the molecule. The biological activity of synthetic streptozotocin was characterised by studies in vivo of its diabetogenic activity and its dose–response curves. After this characterization the excretion pattern of all three labelled forms of streptozotocin was studied. With [1-14C]streptozotocin and [2′-14C]streptozotocin the injected radioactivity was excreted (approx. 70% and 80% respectively) mainly in the urine, the greater part of the excretion occurring in the first 6h period; small amounts (approx. 9% and 8% respectively) were found in the faeces. In contrast, with [3′-methyl-14C]streptozotocin a much smaller proportion (approx. 42%) of the injected radioactivity was excreted in the urine, the major proportion appearing in the first 6h, whereas approx. 53% of the injected radioactivity was retained in the carcasses. In whole-body radioautographic studies very rapid renal clearance and hepatic accumulation of the injected radioactivity was observed with all three labelled forms of the drug. There was some evidence for biliary and intestinal excretion. Major differences were apparent in the tissue-distribution studies, with each of the three labelled forms, particularly with [3′-methyl-14C]streptozotocin. There was no accumulation of [1-14C]streptozotocin in the pancreas for the 6h period after administration. However, with [3′-methyl-14C]streptozotocin (and also [2′-14C]streptozotocin) there was evidence of some pancreatic accumulation after 2h. The results indicate that streptozotocin is subjected to considerable metabolic transformation and to rapid renal clearance. The implication of these suggestions is evaluated with particular reference to the diabetogenic action of streptozotocin.

Whole-body section fluorescence imaging - a novel method for tissue distribution studies of fluorescent substances

2009 ◽  
Vol 4 (2) ◽  
pp. 73-80 ◽  
Author(s):  
Siver Moestue ◽  
Paula Nunez ◽  
Andrew Healey ◽  
Roger Bjerke ◽  
Bård Indrevoll ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Fluorescence Imaging ◽  
Whole Body ◽  
Novel Method ◽  
Distribution Studies ◽  
Body Section

scholarly journals Whole Body Retention and Tissue Distribution Studies of 75Se-selenonorcholesterol and Evaluation of Radiation Dose

RADIOISOTOPES ◽  
1979 ◽  
Vol 28 (2) ◽  
pp. 89-91
Author(s):  
Hirofumi MORI ◽  
Ryusuke FUTATSUYA ◽  
Hikaru SETO ◽  
Kiyoshi KOIZUMI ◽  
Atsushi ANDO ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Tissue Distribution ◽  
Whole Body ◽  
Body Retention ◽  
Distribution Studies

Effect of whole-body hyperthermia on pharmacokinetics and tissue distribution of doxorubicin

1992 ◽  
Vol 8 (1) ◽  
pp. 79-85 ◽  
Author(s):  
R. A. Newman ◽  
D. Dogramatzis ◽  
J. A. Benvenuto ◽  
M. Trevino ◽  
L. C. Stephens ◽  
...  
Keyword(s):  
Tissue Distribution ◽  
Whole Body ◽  
Whole Body Hyperthermia
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