Mutagenicity Studies on Erythritol in Bacterial Reversion Assay Systems and in Chinese Hamster Fibroblast Cells

1996 ◽  
Vol 24 (2) ◽  
pp. S261-S263 ◽  
Author(s):  
Yuji Kawamura ◽  
Yuko Saito ◽  
Mikiro Imamura ◽  
John P. Modderman
Keyword(s):  
Chinese Hamster ◽  
Fibroblast Cells ◽  
Chinese Hamster Fibroblast

Final Report on the Safety Assessment of Polyvinyl Acetate

1992 ◽  
Vol 11 (4) ◽  
pp. 465-473 ◽  
Keyword(s):  
Safety Assessment ◽  
Polyvinyl Acetate ◽  
Chinese Hamster ◽  
Safety Evaluation ◽  
Fibroblast Cell ◽  
Final Report ◽  
Cosmetic Products ◽  
Ames Assay ◽  
Negative Results ◽  
Chinese Hamster Fibroblast

Polyvinyl Acetate, as used in cosmetic products, is a latex emulsion known as the homopolymer of ethenyl acetate. It is used as a binder, emulsion stabilizer, and hair fixative at concentrations less than 25%. Polyvinyl Acetate was nonmutagenic in the Ames assay, with and without activation, and in the Chinese Hamster fibroblast cell assay. Carcinogenic implantation studies using mice gave negative results. It is concluded that the data available are insufficient to support the safety of Polyvinyl Acetate as currently used in cosmetic products. The types of data needed to complete the safety evaluation are listed in the report.

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