Alternative Models for Low Dose-Response Analysis of Biochemical and Immunological Endpoints for Tetrachlorodibenzo-p-dioxin

1995 ◽  
Vol 21 (3) ◽  
pp. 382-396 ◽  
Author(s):  
L.F. Mcgrath ◽  
K.R. Cooper ◽  
P. Georgopoulos ◽  
M.A. Gallo
Keyword(s):  
Dose Response ◽  
Low Dose ◽  
Response Analysis ◽  
Alternative Models ◽  
Tetrachlorodibenzo P Dioxin

scholarly journals Dose-response analysis of bromate-induced DNA damage and mutagenicity is consistent with low-dose linear, nonthreshold processes

2012 ◽  
Vol 54 (1) ◽  
pp. 19-35 ◽  
Author(s):  
Maria A. Spassova ◽  
David J. Miller ◽  
David A. Eastmond ◽  
Nadejda S. Nikolova ◽  
Suryanarayana V. Vulimiri ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dose Response ◽  
Low Dose ◽  
Response Analysis

A Dose Response Analysis of 2000 Consecutive Patients Treated with Low-Dose-Rate Prostate Brachytherapy

Brachytherapy ◽  
2013 ◽  
Vol 12 ◽  
pp. S12
Author(s):  
W. James Morris ◽  
Ingrid Spadinger ◽  
Mira Keyes ◽  
Michael McKenzie ◽  
Tom Pickles
Keyword(s):  
Dose Rate ◽  
Dose Response ◽  
Low Dose ◽  
Response Analysis ◽  
Prostate Brachytherapy ◽  
Low Dose Rate

Endocrine active substances and dose response for individuals and populations

2003 ◽  
Vol 75 (11-12) ◽  
pp. 2159-2166 ◽  
Author(s):  
H. A. Barton
Keyword(s):  
Dose Response ◽  
Low Dose ◽  
Population Level ◽  
Response Analysis ◽  
Health Issues ◽  
Response Characteristics ◽  
Highly Nonlinear ◽  
The Individual ◽  
Active Substances ◽  
Response Behaviors

Dose-response characteristics for endocrine disruption have been major focuses in efforts to understand potential impacts on human and ecological health. Issues include assumptions of thresholds for developmental effects, effects at low doses with nonmonotonic (e.g., "U-shaped") behaviors, population vs. individual responses, and background exposures (e.g., dietary phytoestrogens). Dose-response analysis presents a challenge because it is multidisciplinary, involving biologists and mathematicians. Statistical analyses can be valuable for evaluating issues such as the reproducibility of data as illustrated for contradictory findings on low-dose effects. Mechanistically based modeling provides insights into how perturbations of biological systems by endocrine active substances can create different dose-response behaviors. These analyses have demonstrated that higher order behaviors resulting from the interaction of component parts may appear highly nonlinear, thresholded, low-dose linear, or nonmonotonic, or exhibit hysteresis. Some effects need to be evaluated as population impacts. For example, alterations in male:female ratio may be important at the population level even though not adverse for the individual. Descriptions of the contributions of background exposures to dose-response behaviors are essential. The challenge for improving dose-response analyses is to better understand how system characteristics create different dose-response behaviors. Such generalizations could then provide useful guidance for developing risk assessment approaches.

A Dose-Response Analysis of Nicotine Sensitization in Adolescent Rats D2-Primed as Neonates

2010 ◽  
Author(s):  
Elizabeth A. Hanchak ◽  
Meredith L. Smith ◽  
Jessie J. Smith ◽  
Marla K. Perna ◽  
Russell W. Brown
Keyword(s):  
Dose Response ◽  
Response Analysis ◽  
Adolescent Rats
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