Characterization of the Phosphodiesterase (PDE) Pattern of in Vitro-Generated Human Dendritic Cells (DC) and the Influence of PDE Inhibitors on DC Function

1999 ◽  
Vol 12 (6) ◽  
pp. 377-386 ◽  
Author(s):  
Florian Gantner ◽  
Christian Schudt ◽  
Albrecht Wendel ◽  
Armin Hatzelmann
Keyword(s):  
Dendritic Cells ◽  
Dc Function ◽  
Pde Inhibitors ◽  
Human Dendritic Cells

scholarly journals Effects of Staphylococcus aureus Bacteriophage K on Expression of Cytokines and Activation Markers by Human Dendritic Cells In Vitro

Viruses ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 617 ◽  
Author(s):  
Helen Freyberger ◽  
Yunxiu He ◽  
Amanda Roth ◽  
Mikeljon Nikolich ◽  
Andrey Filippov
Keyword(s):  
Staphylococcus Aureus ◽  
Dendritic Cells ◽  
Inflammatory Response ◽  
Adaptive Immune Response ◽  
Human Monocyte ◽  
Activation Markers ◽  
Mhc I ◽  
Adaptive Immune ◽  
Human Dendritic Cells

A potential concern with bacteriophage (phage) therapeutics is a host-versus-phage response in which the immune system may neutralize or destroy phage particles and thus impair therapeutic efficacy, or a strong inflammatory response to repeated phage exposure might endanger the patient. Current literature is discrepant with regard to the nature and magnitude of innate and adaptive immune response to phages. The purpose of this work was to study the potential effects of Staphylococcus aureus phage K on the activation of human monocyte-derived dendritic cells. Since phage K acquired from ATCC was isolated around 90 years ago, we first tested its activity against a panel of 36 diverse S. aureus clinical isolates from military patients and found that it was lytic against 30/36 (83%) of strains. Human monocyte-derived dendritic cells were used to test for an in vitro phage-specific inflammatory response. Repeated experiments demonstrated that phage K had little impact on the expression of pro- and anti-inflammatory cytokines, or on MHC-I/II and CD80/CD86 protein expression. Given that dendritic cells are potent antigen-presenting cells and messengers between the innate and the adaptive immune systems, our results suggest that phage K does not independently affect cellular immunity or has a very limited impact on it.

Regulatory perspective on in vitro potency assays for human dendritic cells used in anti-tumor immunotherapy

Cytotherapy ◽  
2018 ◽  
Vol 20 (11) ◽  
pp. 1289-1308 ◽  
Author(s):  
CHARLOTTE DE Wolf ◽  
MARJA VAN DE BOVENKAMP ◽  
MARCEL HOEFNAGEL
Keyword(s):  
Dendritic Cells ◽  
Tumor Immunotherapy ◽  
Regulatory Perspective ◽  
Human Dendritic Cells

scholarly journals Characterization of the effects of Butanol fraction from Echinacea purpurea on human dendritic cells using genomic and proteomic studies

2006 ◽  
Vol 20 (5) ◽  
Author(s):  
Ning‐Sun Yang ◽  
Chien‐Yu Wang ◽  
Vani Staniforth ◽  
Ming‐Tsang Chiao ◽  
Po‐Jen Yen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Echinacea Purpurea ◽  
Butanol Fraction ◽  
Human Dendritic Cells

The novel adjuvant CoVaccineHT™ increases the immunogenicity of cell-culture derived influenza A/H5N1 vaccine and induces the maturation of murine and human dendritic cells in vitro

Vaccine ◽  
2009 ◽  
Vol 27 (49) ◽  
pp. 6833-6839 ◽  
Author(s):  
R. Bodewes ◽  
M.M. Geelhoed-Mieras ◽  
J.G.M. Heldens ◽  
J. Glover ◽  
B.N. Lambrecht ◽  
...  
Keyword(s):  
Cell Culture ◽  
Dendritic Cells ◽  
Influenza A ◽  
The Novel ◽  
Human Dendritic Cells ◽  
H5n1 Vaccine

scholarly journals Cloning and Characterization of DULP, a Novel Ubiquitin-Like Molecule from Human Dendritic Cells

2009 ◽  
Vol 6 (1) ◽  
pp. 27-33 ◽  
Author(s):  
Guoyan Liu ◽  
Shuxun Liu ◽  
Ping Li ◽  
Ling Tang ◽  
Yanmei Han ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Human Dendritic Cells

DC-SIGN enhances infection of cells with glycosylated West Nile virus in vitro and virus replication in human dendritic cells induces production of IFN-α and TNF-α

2008 ◽  
Vol 135 (1) ◽  
pp. 64-71 ◽  
Author(s):  
Byron E.E. Martina ◽  
Penelopie Koraka ◽  
Petra van den Doel ◽  
Guus F. Rimmelzwaan ◽  
Bart L. Haagmans ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
West Nile Virus ◽  
Virus Replication ◽  
West Nile ◽  
Tnf Α ◽  
Human Dendritic Cells

Characterization of Human Dendritic Cells at the Materno-Fetal Interface

2007 ◽  
pp. 122-129 ◽  
Author(s):  
Ulrike Kämmerer ◽  
Lorenz Rieger ◽  
Arnd Honig ◽  
Eckhard Kämpgen
Keyword(s):  
Dendritic Cells ◽  
Human Dendritic Cells

Molecular cloning and characterization of a novel V-ATPase associated protein, DVA9.2, from human dendritic cells

Life Sciences ◽  
2006 ◽  
Vol 79 (19) ◽  
pp. 1828-1838 ◽  
Author(s):  
Xingguang Liu ◽  
Chunmei Wang ◽  
Nan Li ◽  
Xuan Zhang ◽  
Yuanyuan Zheng ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Molecular Cloning ◽  
Human Dendritic Cells
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