The Effect of Inhibitors of Na/H Exchange and Na/Ca Exchange on Airway Smooth Muscle Contractility

1994 ◽  
Vol 7 (2) ◽  
pp. 99-102 ◽  
Author(s):  
A.J. Knox ◽  
P. Ajao
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility ◽  
Effect Of Inhibitors

scholarly journals IL-17A Recruits Rab35 to IL-17R to Mediate PKCα-Dependent Stress Fiber Formation and Airway Smooth Muscle Contractility

2019 ◽  
Vol 202 (5) ◽  
pp. 1540-1548 ◽  
Author(s):  
Katarzyna Bulek ◽  
Xing Chen ◽  
Vandy Parron ◽  
Aparna Sundaram ◽  
Tomasz Herjan ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Stress Fiber ◽  
Fiber Formation ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility ◽  
Stress Fiber Formation

scholarly journals Prenatal Exposure to Respiratory Syncytial Virus Alters Postnatal Immunity and Airway Smooth Muscle Contractility during Early-Life Reinfections

PLoS ONE ◽  
2017 ◽  
Vol 12 (2) ◽  
pp. e0168786 ◽  
Author(s):  
Paul M. Brown ◽  
Terri J. Harford ◽  
Vandana Agrawal ◽  
Belinda Yen-Lieberman ◽  
Fariba Rezaee ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Respiratory Syncytial Virus ◽  
Airway Smooth Muscle ◽  
Prenatal Exposure ◽  
Early Life ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility ◽  
Syncytial Virus

Airway smooth muscle contractility is increased following coculture with fibrocytes

2016 ◽  
Author(s):  
Ruth Saunders ◽  
Davinder Kaur ◽  
Fay Hollins ◽  
Andrew Wardlaw ◽  
Peter Bradding ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility

Effects Of Sensitized Splenocytes On Airway Smooth Muscle Contractility

2010 ◽  
Author(s):  
Jack Fairbank ◽  
Emily M. Nakada ◽  
Linda Kachmar ◽  
Sharon R. Bullimore ◽  
Elizabeth Fixman ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Muscle Contractility ◽  
Smooth Muscle Contractility

Hyperoxic exposure enhances airway reactivity of newborn guinea pigs

1993 ◽  
Vol 74 (6) ◽  
pp. 2649-2654 ◽  
Author(s):  
C. F. Uyehara ◽  
B. E. Pichoff ◽  
H. H. Sim ◽  
H. S. Uemura ◽  
K. T. Nakamura
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Guinea Pigs ◽  
Airway Hyperreactivity ◽  
Muscle Contractility ◽  
Airway Reactivity ◽  
Smooth Muscle Contractility ◽  
Contractile Responses ◽  
Hyperoxic Exposure

To determine whether altered airway smooth muscle contractility contributes to airway hyperreactivity resulting from hyperoxic exposure, in vitro contractile responses of airways to two physiological constrictors, acetylcholine (10(-9) to 10(-4) M) and histamine (10(-8) to 10(-4) M), were examined. Extrathoracic trachea, intrathoracic trachea, and bronchus from 1- to 2-day-old (newborn) guinea pigs exposed to 85% oxygen for 84 h were compared with tissues obtained from newborns reared in room air. Responses in the presence and absence of aspirin (ASA; 10(-3) M) were compared. Hyperoxic exposure did not affect the histology of the airway epithelia. Contractile responses to acetylcholine and histamine were similar. Without ASA, maximal tensions generated were higher in both extrathoracic and intrathoracic trachea obtained from hyperoxia-exposed neonates than in trachea from newborns reared in room air. ASA caused maximal tensions of trachea from newborns reared in room air to increase but did not affect the already increased contractility of trachea from hyperoxia-exposed animals; the tensions achieved in hyperoxic tissues with and without ASA were similar to the hyperactive responses induced by ASA in tissues from animals reared in room air. Bronchi showed responses similar to those seen in tracheal segments. Thus, despite no apparent histological effect on the airway epithelium, hyperoxic exposure seems to increase airway smooth muscle contractility, is nonspecific for different constricting agents, and shows no regional differences in airway reactivity.

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